The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.

Detalhes bibliográficos
Autor(a) principal: Lima, Rosangela G
Data de Publicação: 2002
Outros Autores: Van Weyenbergh, Johan Jozef Rosa Maria, Saraiva, Elvira Maria B, Barral Netto, Manoel, Castro Filho, Bernardo Galvão, Bou-Habib, Dumith Chequer
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5488
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Lima, Rosangela GVan Weyenbergh, Johan Jozef Rosa MariaSaraiva, Elvira Maria BBarral Netto, ManoelCastro Filho, Bernardo GalvãoBou-Habib, Dumith Chequer2012-09-06T17:39:06Z2012-09-06T17:39:06Z2002LIMA, R.G. et al. The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells. Journal of Infectious Disease, v. 185, n. 11), p. 1561-6, Jun. 2002.0022-1899https://www.arca.fiocruz.br/handle/icict/5488engThe replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilClearance of apoptotic cells increases macrophage secretion of antiinflammatory mediators and might modulate viral replication in human immunodeficiency virus (HIV) type 1–infected macrophages. To study this, primary macrophages were infected with HIV-1 and exposed to apoptotic cells. It was found that phagocytosis of apoptotic cells potently enhanced HIV-1 growth. The peptide Arg-Gly-Asp-Ser, which binds to integrin receptors, inhibited the uptake of apoptotic cells and the subsequent enhancement of HIV-1 replication. Viral replication was preceded by increased secretion of transforming growth factor (TGF)–b1 and partially reverted by anti–TGF-b1 antibodies. Moreover, anti–TGF-b1 antibodies inhibited HIV-1 replication in macrophages not exposed to apoptotic cells. A positive correlation was observed between TGFb1 production and HIV-1 growth, and the addition of TGF-b1 amplified HIV-1 replication in macrophages from low TGF-b1 producers. The findings suggest that TGF-b1 favors HIV-1 replication in macrophages and that the clearance of apoptotic cells by HIV-1–infected macrophages contributes to persistent viremia in patients infected with HIV-1.ApoptoseHIV-1/fisiologiaMacrófagos/virologiaFagocitoseReplicação ViralCélulas CultivadasInfecções por HIV/virologiaHIV-1/patogenicidadeHumanosFator Transformador de Crescimento beta/imunologiaFator Transformador de Crescimento beta/metabolismoFator Transformador de Crescimento beta1info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLima RG The replication of human ....pdfLima RG The replication of human ....pdfapplication/pdf118124https://www.arca.fiocruz.br/bitstream/icict/5488/1/Lima%20RG%20The%20replication%20of%20human%20....pdfa010923612eef7c104e7a3063286d053MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5488/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTLima RG The replication of human ....pdf.txtLima RG The replication of human ....pdf.txtExtracted texttext/plain32992https://www.arca.fiocruz.br/bitstream/icict/5488/5/Lima%20RG%20The%20replication%20of%20human%20....pdf.txt4698586c179bc821187e79675cc0a2d6MD55THUMBNAILLima RG The replication of human ....pdf.jpgLima RG The replication of human ....pdf.jpgGenerated Thumbnailimage/jpeg2287https://www.arca.fiocruz.br/bitstream/icict/5488/4/Lima%20RG%20The%20replication%20of%20human%20....pdf.jpg290827b2f308b53f0cbcff1e6e0c2a24MD54icict/54882023-03-15 14:33:13.922oai:www.arca.fiocruz.br:icict/5488TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
title The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
spellingShingle The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
Lima, Rosangela G
Apoptose
HIV-1/fisiologia
Macrófagos/virologia
Fagocitose
Replicação Viral
Células Cultivadas
Infecções por HIV/virologia
HIV-1/patogenicidade
Humanos
Fator Transformador de Crescimento beta/imunologia
Fator Transformador de Crescimento beta/metabolismo
Fator Transformador de Crescimento beta1
title_short The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
title_full The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
title_fullStr The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
title_full_unstemmed The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
title_sort The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells.
author Lima, Rosangela G
author_facet Lima, Rosangela G
Van Weyenbergh, Johan Jozef Rosa Maria
Saraiva, Elvira Maria B
Barral Netto, Manoel
Castro Filho, Bernardo Galvão
Bou-Habib, Dumith Chequer
author_role author
author2 Van Weyenbergh, Johan Jozef Rosa Maria
Saraiva, Elvira Maria B
Barral Netto, Manoel
Castro Filho, Bernardo Galvão
Bou-Habib, Dumith Chequer
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Rosangela G
Van Weyenbergh, Johan Jozef Rosa Maria
Saraiva, Elvira Maria B
Barral Netto, Manoel
Castro Filho, Bernardo Galvão
Bou-Habib, Dumith Chequer
dc.subject.decs.pt_BR.fl_str_mv Apoptose
HIV-1/fisiologia
Macrófagos/virologia
Fagocitose
Replicação Viral
Células Cultivadas
Infecções por HIV/virologia
HIV-1/patogenicidade
Humanos
Fator Transformador de Crescimento beta/imunologia
Fator Transformador de Crescimento beta/metabolismo
Fator Transformador de Crescimento beta1
topic Apoptose
HIV-1/fisiologia
Macrófagos/virologia
Fagocitose
Replicação Viral
Células Cultivadas
Infecções por HIV/virologia
HIV-1/patogenicidade
Humanos
Fator Transformador de Crescimento beta/imunologia
Fator Transformador de Crescimento beta/metabolismo
Fator Transformador de Crescimento beta1
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2012-09-06T17:39:06Z
dc.date.available.fl_str_mv 2012-09-06T17:39:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, R.G. et al. The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells. Journal of Infectious Disease, v. 185, n. 11), p. 1561-6, Jun. 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5488
dc.identifier.issn.none.fl_str_mv 0022-1899
identifier_str_mv LIMA, R.G. et al. The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells. Journal of Infectious Disease, v. 185, n. 11), p. 1561-6, Jun. 2002.
0022-1899
url https://www.arca.fiocruz.br/handle/icict/5488
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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