Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51

Detalhes bibliográficos
Autor(a) principal: Gunatilleke, Shamila S.
Data de Publicação: 2012
Outros Autores: Calvet, Claudia M. d'Avila, Johnston, Jonathan B., Chen, Chiung-Kuang, Erenburg, Grigori, Gut, Jiri, Engel, Juan C., Ang, Kenny K. H., Mulvaney, Joseph, Chen, Steven, Arkin, Michelle R., McKerrow, James H., Podust, Larissa M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18797
Resumo: University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.
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spelling Gunatilleke, Shamila S.Calvet, Claudia M. d'AvilaJohnston, Jonathan B.Chen, Chiung-KuangErenburg, GrigoriGut, JiriEngel, Juan C.Ang, Kenny K. H.Mulvaney, JosephChen, StevenArkin, Michelle R.McKerrow, James H.Podust, Larissa M.2017-05-09T16:19:56Z2017-05-09T16:19:56Z2012GUNATILLEKE, Shamila S. et al. Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis, v.6, n.7. e1736, 16p, July 2012.1935-2727https://www.arca.fiocruz.br/handle/icict/1879710.1371/journal.pntd.00017361935-2735engPublic Library of ScienceTrypanosoma cruziDoença de ChagasTrypanosoma cruziChagas DiseaseDiverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.University of California San Francisco. Department of Pharmaceutical Chemistry. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pharmaceutical Chemistry. San Francisco, CA, USA.University of Western Ontario. King’s University College. London, Ontario, Canada.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA / University of California San Francisco. Department of Medicine. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due to heart failure, as well as inflicting a heavy economic burden in affected regions, Chagas Disease elicits scant notice from the pharmaceutical industry because of adverse economic incentives. The discovery and development of new routes to chemotherapy for Chagas Disease is a clear priority.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18797/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALclaudia_calvet_etal_IOC_2012.pdfclaudia_calvet_etal_IOC_2012.pdfapplication/pdf3309281https://www.arca.fiocruz.br/bitstream/icict/18797/2/claudia_calvet_etal_IOC_2012.pdf51dee8c7003edf1663b0e60c3f2b0747MD52TEXTclaudia_calvet_etal_IOC_2012.pdf.txtclaudia_calvet_etal_IOC_2012.pdf.txtExtracted texttext/plain70422https://www.arca.fiocruz.br/bitstream/icict/18797/3/claudia_calvet_etal_IOC_2012.pdf.txt21dda80b4fe2e3909cee256369749064MD53icict/187972018-08-15 02:12:41.206oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
title Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
spellingShingle Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
Gunatilleke, Shamila S.
Trypanosoma cruzi
Doença de Chagas
Trypanosoma cruzi
Chagas Disease
title_short Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
title_full Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
title_fullStr Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
title_full_unstemmed Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
title_sort Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
author Gunatilleke, Shamila S.
author_facet Gunatilleke, Shamila S.
Calvet, Claudia M. d'Avila
Johnston, Jonathan B.
Chen, Chiung-Kuang
Erenburg, Grigori
Gut, Jiri
Engel, Juan C.
Ang, Kenny K. H.
Mulvaney, Joseph
Chen, Steven
Arkin, Michelle R.
McKerrow, James H.
Podust, Larissa M.
author_role author
author2 Calvet, Claudia M. d'Avila
Johnston, Jonathan B.
Chen, Chiung-Kuang
Erenburg, Grigori
Gut, Jiri
Engel, Juan C.
Ang, Kenny K. H.
Mulvaney, Joseph
Chen, Steven
Arkin, Michelle R.
McKerrow, James H.
Podust, Larissa M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gunatilleke, Shamila S.
Calvet, Claudia M. d'Avila
Johnston, Jonathan B.
Chen, Chiung-Kuang
Erenburg, Grigori
Gut, Jiri
Engel, Juan C.
Ang, Kenny K. H.
Mulvaney, Joseph
Chen, Steven
Arkin, Michelle R.
McKerrow, James H.
Podust, Larissa M.
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Doença de Chagas
topic Trypanosoma cruzi
Doença de Chagas
Trypanosoma cruzi
Chagas Disease
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chagas Disease
description University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-05-09T16:19:56Z
dc.date.available.fl_str_mv 2017-05-09T16:19:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUNATILLEKE, Shamila S. et al. Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis, v.6, n.7. e1736, 16p, July 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18797
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0001736
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv GUNATILLEKE, Shamila S. et al. Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis, v.6, n.7. e1736, 16p, July 2012.
1935-2727
10.1371/journal.pntd.0001736
1935-2735
url https://www.arca.fiocruz.br/handle/icict/18797
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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