Pathogenesis of HTLV-1 infection and progression biomarkers: An overview

Detalhes bibliográficos
Autor(a) principal: Brites, Carlos
Data de Publicação: 2021
Outros Autores: Grassi, Maria Fernanda, Quaresma, Juarez Antonio Simões, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosario
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49072
Resumo: Health Surveillance Secretariat from the Department of Diseases of Chronic Conditions and Sexually Transmitted Infections of the Ministry of Health of Brazil, the National Council for Scientific and Technological Development (CNPQ - Grant #301869/2017-0 ACRV; #312979/2018-5 RI; #304811/2017-3 MFRG), and the National Foundation for the Development of Private Higher Education − FUNADESP (http://www.funadesp.org.br/), grant #9600140 MFRG.
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spelling Brites, CarlosGrassi, Maria FernandaQuaresma, Juarez Antonio SimõesIshak, RicardoVallinoto, Antonio Carlos Rosario2021-09-14T11:48:32Z2021-09-14T11:48:32Z2021BRITES, Carlos et al. Pathogenesis of HTLV-1 infection and progression biomarkers: An overview. Brazilian Journal of Infectious Diseases, v. 25, n. 3, 2021.1413-8670https://www.arca.fiocruz.br/handle/icict/4907210.1016/j.bjid.2021.101594Health Surveillance Secretariat from the Department of Diseases of Chronic Conditions and Sexually Transmitted Infections of the Ministry of Health of Brazil, the National Council for Scientific and Technological Development (CNPQ - Grant #301869/2017-0 ACRV; #312979/2018-5 RI; #304811/2017-3 MFRG), and the National Foundation for the Development of Private Higher Education − FUNADESP (http://www.funadesp.org.br/), grant #9600140 MFRG.Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Laboratory of Infectious Diseases Research, Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Federal University of Pará. Nucleus of Tropical Medicine. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.Infection by human T-cell lymphotropic virus type 1 (HTLV-1) occurs in lymphocytes, which travel throughout the body, thus affecting several target organs and causing varied clinical outcomes, particularly in populations that are underserved and do not have access to healthcare. However, the mechanism of pathogenesis is not yet fully understood. The TAX and HTLV-1 basic leucine zipper factor (HBZ) proteins maintain viral persistence and affect pathogenesis through cell proliferation and immune and inflammatory responses that accompany each clinical manifestation. TAX expression leads to inhibition of transcription error control, OX40 overexpression, and cell proliferation in adult T-cell leukemia (ATL). OX40 levels are elevated in the central nervous system (CNS), and the expression of TAX in the CNS causes neuronal damage and loss of immune reactivity among patients with HTLV-1-associated myelopathy (HAM). HBZ reduces viral replication and suppresses the immune response. Its cell compartmentalization has been associated with the pathogenesis of HAM (cytoplasmic localization) and ATL (nuclear localization). TAX and HBZ seem to act antagonistically in immune responses, affecting the pathogenesis of HTLV-1 infection. The progression from HTLV-1 infection to disease is a consequence of HTLV-1 replication in CD4+ T and CD8+ T lymphocytes and the imbalance between proinflammatory and anti-inflammatory cytokines. The compartmentalization of HBZ suggests that this protein may be an additional tool for assessing immune and inflammatory responses, in addition to those already recognized as potential biomarkers associated with progression from infection to disease (including human leukocyte antigen (HLA), killer immunoglobulin- like receptors (KIR), interleukin (IL)-6, IL-10, IL-28, Fas, Fas ligand, interferon (IFN)-g, tumor necrosis factor (TNF)-a, and mannose-binding lectin).engElsevierHTLV-1PatogêneseBiomarcadoresVírus Linfotrópico T Tipo 1 HumanoInfecçõesHTLV-1PathogenesisBiomarkersTAXHBZPathogenesis of HTLV-1 infection and progression biomarkers: An overviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
title Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
spellingShingle Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
Brites, Carlos
HTLV-1
Patogênese
Biomarcadores
Vírus Linfotrópico T Tipo 1 Humano
Infecções
HTLV-1
Pathogenesis
Biomarkers
TAX
HBZ
title_short Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
title_full Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
title_fullStr Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
title_full_unstemmed Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
title_sort Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
author Brites, Carlos
author_facet Brites, Carlos
Grassi, Maria Fernanda
Quaresma, Juarez Antonio Simões
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosario
author_role author
author2 Grassi, Maria Fernanda
Quaresma, Juarez Antonio Simões
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosario
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Brites, Carlos
Grassi, Maria Fernanda
Quaresma, Juarez Antonio Simões
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosario
dc.subject.other.pt_BR.fl_str_mv HTLV-1
Patogênese
Biomarcadores
Vírus Linfotrópico T Tipo 1 Humano
Infecções
topic HTLV-1
Patogênese
Biomarcadores
Vírus Linfotrópico T Tipo 1 Humano
Infecções
HTLV-1
Pathogenesis
Biomarkers
TAX
HBZ
dc.subject.en.pt_BR.fl_str_mv HTLV-1
Pathogenesis
Biomarkers
TAX
HBZ
description Health Surveillance Secretariat from the Department of Diseases of Chronic Conditions and Sexually Transmitted Infections of the Ministry of Health of Brazil, the National Council for Scientific and Technological Development (CNPQ - Grant #301869/2017-0 ACRV; #312979/2018-5 RI; #304811/2017-3 MFRG), and the National Foundation for the Development of Private Higher Education − FUNADESP (http://www.funadesp.org.br/), grant #9600140 MFRG.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-14T11:48:32Z
dc.date.available.fl_str_mv 2021-09-14T11:48:32Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRITES, Carlos et al. Pathogenesis of HTLV-1 infection and progression biomarkers: An overview. Brazilian Journal of Infectious Diseases, v. 25, n. 3, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49072
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.eissn.none.fl_str_mv 10.1016/j.bjid.2021.101594
identifier_str_mv BRITES, Carlos et al. Pathogenesis of HTLV-1 infection and progression biomarkers: An overview. Brazilian Journal of Infectious Diseases, v. 25, n. 3, 2021.
1413-8670
10.1016/j.bjid.2021.101594
url https://www.arca.fiocruz.br/handle/icict/49072
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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