Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil

Detalhes bibliográficos
Autor(a) principal: Martins, Ademir Jesus
Data de Publicação: 2009
Outros Autores: Lins, Rachel Mazzei Moura de Andrade, Linss, Jutta Gerlinde Birgitt, Peixoto, Alexandre Afranio, Valle, Denise
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30810
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores;Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Laboratório de Entomologia. Rio de Janeiro, RH, Brasil.
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spelling Martins, Ademir JesusLins, Rachel Mazzei Moura de AndradeLinss, Jutta Gerlinde BirgittPeixoto, Alexandre AfranioValle, Denise2018-12-31T13:15:09Z2018-12-31T13:15:09Z2009MARTINS, Ademir Jesus; et al. Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil. Am. J. Trop. Med. Hyg., v.81. n.1, p.108–115, 2009.0002-9637https://www.arca.fiocruz.br/handle/icict/308101476-1645engAmerican Society of Tropical Medicine and HygieneAedes aegyptiPolimorfismoBrasilresistência a piretróideResistência MetabólicaAedes aegyptipyrethroid resistanceBrazilPolymorphismMetabolic ResistanceVoltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores;Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Laboratório de Entomologia. Rio de Janeiro, RH, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores;Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Laboratório de Entomologia. Rio de Janeiro, RH, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores;Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Laboratório de Entomologia. Rio de Janeiro, RH, Brasil.The nature of pyrethroid resistance in Aedes aegypti Brazilian populations was investigated. Quantification of enzymes related to metabolic resistance in two distinct populations, located in the Northeast and Southeast regions, revealed increases in Glutathione- S- transferase (GST) and Esterase levels. Additionally, polymorphism was found in the IIS6 region of Ae. aegypti voltage-gated sodium channel ( AaNa V ), the pyrethroid target site. Sequences were classified in two haplotype groups, A and B, according to the size of the intron in that region. Rockefeller, a susceptible control lineage, contains only B sequences. In field populations, some A sequences present a substitution in the 1011 site (Ile/Met). When resistant and susceptible individuals were compared, the frequency of both A (with the Met mutation) and B sequences were slightly increased in resistant specimens. The involvement of the AaNa V polymorphism in pyrethroid resistance and the metabolic mechanisms that lead to potential cross-resistance between organophosphate and pyrethroids are discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30810/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALademirj_martins_etal_IOC_2009.pdfademirj_martins_etal_IOC_2009.pdfapplication/pdf782320https://www.arca.fiocruz.br/bitstream/icict/30810/2/ademirj_martins_etal_IOC_2009.pdfc09168e84e86f9d803fa334cecbc610dMD52TEXTademirj_martins_etal_IOC_2009.pdf.txtademirj_martins_etal_IOC_2009.pdf.txtExtracted texttext/plain44207https://www.arca.fiocruz.br/bitstream/icict/30810/3/ademirj_martins_etal_IOC_2009.pdf.txt320e3ffb4e4de56f25ee3d671ba13f8dMD53icict/308102019-01-01 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dc.title.pt_BR.fl_str_mv Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
title Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
spellingShingle Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
Martins, Ademir Jesus
Aedes aegypti
Polimorfismo
Brasil
resistência a piretróide
Resistência Metabólica
Aedes aegypti
pyrethroid resistance
Brazil
Polymorphism
Metabolic Resistance
title_short Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
title_full Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
title_fullStr Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
title_full_unstemmed Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
title_sort Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
author Martins, Ademir Jesus
author_facet Martins, Ademir Jesus
Lins, Rachel Mazzei Moura de Andrade
Linss, Jutta Gerlinde Birgitt
Peixoto, Alexandre Afranio
Valle, Denise
author_role author
author2 Lins, Rachel Mazzei Moura de Andrade
Linss, Jutta Gerlinde Birgitt
Peixoto, Alexandre Afranio
Valle, Denise
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Martins, Ademir Jesus
Lins, Rachel Mazzei Moura de Andrade
Linss, Jutta Gerlinde Birgitt
Peixoto, Alexandre Afranio
Valle, Denise
dc.subject.other.pt_BR.fl_str_mv Aedes aegypti
Polimorfismo
Brasil
resistência a piretróide
Resistência Metabólica
topic Aedes aegypti
Polimorfismo
Brasil
resistência a piretróide
Resistência Metabólica
Aedes aegypti
pyrethroid resistance
Brazil
Polymorphism
Metabolic Resistance
dc.subject.en.pt_BR.fl_str_mv Aedes aegypti
pyrethroid resistance
Brazil
Polymorphism
Metabolic Resistance
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores;Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Laboratório de Entomologia. Rio de Janeiro, RH, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-12-31T13:15:09Z
dc.date.available.fl_str_mv 2018-12-31T13:15:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Ademir Jesus; et al. Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil. Am. J. Trop. Med. Hyg., v.81. n.1, p.108–115, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30810
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
dc.identifier.eissn.none.fl_str_mv 1476-1645
identifier_str_mv MARTINS, Ademir Jesus; et al. Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil. Am. J. Trop. Med. Hyg., v.81. n.1, p.108–115, 2009.
0002-9637
1476-1645
url https://www.arca.fiocruz.br/handle/icict/30810
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30810/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/30810/2/ademirj_martins_etal_IOC_2009.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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