Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

Detalhes bibliográficos
Autor(a) principal: Sharma, Shruti
Data de Publicação: 2011
Outros Autores: Oliveira, Rosane Batista de, Kalantari, Parisa, Parroche, Peggy, Goutagny, Nadege, Jiang, Zhaozhao, Chan, Jennie, Bartholomeu, Daniella Castanheira, Lauw, Fanny, Hall, J. Perry, Barber, Glen N., Gazzinelli, Ricardo Tostes, Fitzgerald, Katherine A., Golenbock, Douglas Taylor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11663
Resumo: University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA
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spelling Sharma, ShrutiOliveira, Rosane Batista deKalantari, ParisaParroche, PeggyGoutagny, NadegeJiang, ZhaozhaoChan, JennieBartholomeu, Daniella CastanheiraLauw, FannyHall, J. PerryBarber, Glen N.Gazzinelli, Ricardo TostesFitzgerald, Katherine A.Golenbock, Douglas Taylor2015-08-31T18:10:09Z2015-08-31T18:10:09Z2011SHARMA, Shruti et al. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity, vol. 35, n. 2, p.194-207, 2011.1074-7613 Immunityhttps://www.arca.fiocruz.br/handle/icict/11663engElsevierInnate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genomeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia, Bioquimica e Imunologia. Belo Horizonte, MG, BrasilUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USADepartment of Inflammation and Remodeling, Pfizer. Cambridge, MA, USAUniversity of Miami School of Medicine. Department of Medicine. Division of Hematology and Oncology. Miami, FL, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia, Bioquimica e Imunologia. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Imunopatologia. Belo Horizonte, MG, BrasilUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversity of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAAlthough Toll-like receptor 9 (TLR9) has been implicated in regulating cytokine and type I interferon (IFN) production during malaria in humans and mice, the high AT content of the Plasmodium falciparum genome prompted us to examine the possibility that malarial DNA triggered TLR9-independent DNA sensing pathways. Over 6000 ATTTTTAC (“AT-rich”) motifs are present in the genome of P. falciparum, which we show here potently induce type I IFNs. Parasite DNA, parasitized erythrocytes and oligonucleotides containing the AT-r motif induce type I IFNs via a pathway that did not involve previously described sensors including TLR9, DAI, RNA polymerase-III or IFI16/p204. Rather, AT-rich DNA sensing involved an unknown receptor that coupled to STING, TBK1 and IRF3-IRF7 signaling pathway. Mice lacking both IRF3 and IRF7, the kinase TBK1 or the type I IFN receptor were resistant to otherwise lethal cerebral malaria. Collectively, these observations implicate AT-rich DNA sensing via STING, TBK1 and IRF3-IRF7 in P. falciparum malaria.MalariaPlasmodium falciparuminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11663/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALInnate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.pdfInnate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.pdfapplication/pdf13560839https://www.arca.fiocruz.br/bitstream/icict/11663/2/Innate%20immune%20recognition%20of%20an%20AT-rich%20stem-loop%20DNA%20motif%20in%20the%20Plasmodium%20falciparum%20genome.pdfde23e4884d718a23dd2c980651b9a4beMD52TEXTInnate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.pdf.txtInnate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.pdf.txtExtracted texttext/plain25https://www.arca.fiocruz.br/bitstream/icict/11663/3/Innate%20immune%20recognition%20of%20an%20AT-rich%20stem-loop%20DNA%20motif%20in%20the%20Plasmodium%20falciparum%20genome.pdf.txt55182c43eecf0429a975fdcdddb487e7MD53icict/116632019-06-19 10:05:26.821oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:05:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
title Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
spellingShingle Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
Sharma, Shruti
Malaria
Plasmodium falciparum
title_short Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
title_full Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
title_fullStr Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
title_full_unstemmed Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
title_sort Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
author Sharma, Shruti
author_facet Sharma, Shruti
Oliveira, Rosane Batista de
Kalantari, Parisa
Parroche, Peggy
Goutagny, Nadege
Jiang, Zhaozhao
Chan, Jennie
Bartholomeu, Daniella Castanheira
Lauw, Fanny
Hall, J. Perry
Barber, Glen N.
Gazzinelli, Ricardo Tostes
Fitzgerald, Katherine A.
Golenbock, Douglas Taylor
author_role author
author2 Oliveira, Rosane Batista de
Kalantari, Parisa
Parroche, Peggy
Goutagny, Nadege
Jiang, Zhaozhao
Chan, Jennie
Bartholomeu, Daniella Castanheira
Lauw, Fanny
Hall, J. Perry
Barber, Glen N.
Gazzinelli, Ricardo Tostes
Fitzgerald, Katherine A.
Golenbock, Douglas Taylor
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sharma, Shruti
Oliveira, Rosane Batista de
Kalantari, Parisa
Parroche, Peggy
Goutagny, Nadege
Jiang, Zhaozhao
Chan, Jennie
Bartholomeu, Daniella Castanheira
Lauw, Fanny
Hall, J. Perry
Barber, Glen N.
Gazzinelli, Ricardo Tostes
Fitzgerald, Katherine A.
Golenbock, Douglas Taylor
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium falciparum
topic Malaria
Plasmodium falciparum
description University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2015-08-31T18:10:09Z
dc.date.available.fl_str_mv 2015-08-31T18:10:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SHARMA, Shruti et al. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity, vol. 35, n. 2, p.194-207, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11663
dc.identifier.issn.none.fl_str_mv 1074-7613 Immunity
identifier_str_mv SHARMA, Shruti et al. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity, vol. 35, n. 2, p.194-207, 2011.
1074-7613 Immunity
url https://www.arca.fiocruz.br/handle/icict/11663
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11663/1/license.txt
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