Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay

Detalhes bibliográficos
Autor(a) principal: Gomes-Carneiro, Maria Regina
Data de Publicação: 1998
Outros Autores: Felzenszwalb, Israel, Paumgartten, Francisco J. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29205
Resumo: Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil
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spelling Gomes-Carneiro, Maria ReginaFelzenszwalb, IsraelPaumgartten, Francisco J. R.2018-10-01T16:35:59Z2018-10-01T16:35:59Z1998GOMES-CARNEIRO, Maria Regina; FELZENSZWALB, Israel; PAUMGARTTEN, Francisco J.R. Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay. Mutation Research, v.416, n. 1-2, p.129-136, 1998https://www.arca.fiocruz.br/handle/icict/2920510.1016/S1383-5718(98)00077-11383-5718engElsevierGenotoxicidadeSalmonella TyphimuriumMonoterpeneEssential OilGenotoxicitySalmonella TyphimuriumAmes TestGenotoxicitySalmonella TyphimuriumMutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assayinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, BrasilUniversidade de Estado do Rio de Janeiro. Instituto de Biologia. Departmento de Biofı́sica e Biometria. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, BrasilThe essential oils and their monoterpenoid constituents have been widely used as fragrances in cosmetics, as flavouring food additives, as scenting agents in a variety of household products, as active ingredients in some old drugs, and as intermediates in the synthesis of perfume chemicals. The present study was undertaken to investigate the mutagenic potential of six monoterpenoid compounds: two aldehydes (citral and citronellal), a ketone ((+/-)-camphor), an oxide (1,8-cineole, also known as eucalyptol), and two alcohols (terpineol and (-)-menthol). It is part of a more comprehensive toxicological screening of monoterpenes under way at our laboratory. Mutagenicity was evaluated by the Salmonella/microsome assay (TA97a, TA98, TA100 and TA102 tester strains), without and with addition of an extrinsic metabolic activation system (lyophilized rat liver S9 fraction induced by Aroclor 1254). In all cases, the upper limit of the dose interval tested was either the highest non-toxic dose or the lowest dose of the monoterpene toxic to TA100 strain in the preliminary toxicity test. No mutagenic effect was found with (+/-) camphor, citral, citronellal, 1,8-cineole, and (-) menthol. Terpineol caused a slight but dose-related increase in the number of his+ revertants with TA102 tester strain both without and with addition of S9 mixture. The results from this study therefore suggest that, with the exception of terpineol, the monoterpenoid compounds tested are not mutagenic in the Ames test.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29205/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMutagenicityTesting.pdfMutagenicityTesting.pdfapplication/pdf413690https://www.arca.fiocruz.br/bitstream/icict/29205/2/MutagenicityTesting.pdf95923ccd8dc00f127462625b03d43131MD52TEXTMutagenicityTesting.pdf.txtMutagenicityTesting.pdf.txtExtracted texttext/plain20169https://www.arca.fiocruz.br/bitstream/icict/29205/3/MutagenicityTesting.pdf.txtacbf1967b5959d78bc9b5bd30b014c5eMD53icict/292052023-01-12 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dc.title.pt_BR.fl_str_mv Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
title Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
spellingShingle Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
Gomes-Carneiro, Maria Regina
Genotoxicidade
Salmonella Typhimurium
Monoterpene
Essential Oil
Genotoxicity
Salmonella Typhimurium
Ames Test
Genotoxicity
Salmonella Typhimurium
title_short Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
title_full Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
title_fullStr Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
title_full_unstemmed Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
title_sort Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay
author Gomes-Carneiro, Maria Regina
author_facet Gomes-Carneiro, Maria Regina
Felzenszwalb, Israel
Paumgartten, Francisco J. R.
author_role author
author2 Felzenszwalb, Israel
Paumgartten, Francisco J. R.
author2_role author
author
dc.contributor.author.fl_str_mv Gomes-Carneiro, Maria Regina
Felzenszwalb, Israel
Paumgartten, Francisco J. R.
dc.subject.other.pt_BR.fl_str_mv Genotoxicidade
Salmonella Typhimurium
topic Genotoxicidade
Salmonella Typhimurium
Monoterpene
Essential Oil
Genotoxicity
Salmonella Typhimurium
Ames Test
Genotoxicity
Salmonella Typhimurium
dc.subject.en.pt_BR.fl_str_mv Monoterpene
Essential Oil
Genotoxicity
Salmonella Typhimurium
Ames Test
dc.subject.decs.pt_BR.fl_str_mv Genotoxicity
Salmonella Typhimurium
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2018-10-01T16:35:59Z
dc.date.available.fl_str_mv 2018-10-01T16:35:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES-CARNEIRO, Maria Regina; FELZENSZWALB, Israel; PAUMGARTTEN, Francisco J.R. Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay. Mutation Research, v.416, n. 1-2, p.129-136, 1998
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29205
dc.identifier.doi.none.fl_str_mv 10.1016/S1383-5718(98)00077-1
dc.identifier.eissn.none.fl_str_mv 1383-5718
identifier_str_mv GOMES-CARNEIRO, Maria Regina; FELZENSZWALB, Israel; PAUMGARTTEN, Francisco J.R. Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay. Mutation Research, v.416, n. 1-2, p.129-136, 1998
10.1016/S1383-5718(98)00077-1
1383-5718
url https://www.arca.fiocruz.br/handle/icict/29205
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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