High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47861 |
Resumo: | Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus. AM, Brasil. |
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Chaves, Yuri OliveiraPereira, Flávio RibeiroPinheiro, Rebeca de SouzaBatista, Diego Rafael LimaBalieiro, Antônio Alcirley da SilvaLacerda, Marcus Vinicius Guimarães deNogueira, Paulo AfonsoGuimarães, Monick Lindenmeyer2021-06-24T18:51:11Z2021-06-24T18:51:11Z2021CHAVES, Yuri Oliveira et al. High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil. BioMed Resarch International, v. 2021, Article ID 5567332, 9 p, 2021.2314-6141https://www.arca.fiocruz.br/handle/icict/4786110.1155/2021/5567332engHindawiAlta taxa de detecçãoMutações de resistência a medicamentosPacientes com HIVFalha na terapia antirretroviral combinadaManaus, BrasilHigh Detection RateDrug Resistance MutationsPatientsFailure of treatmentCombined Antiretroviral TherapyManaus, BrazilHIVHigh Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus. AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil.Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus AM, Brasil.Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus AM, Brasil.Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manausm AM, Brasil.Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil..Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Virologic failure may occur because of poor treatment adherence and/or viral drug resistance mutations (DRM). In Brazil, the northern region exhibits the worst epidemiological scenarios for the human immunodeficiency virus (HIV). Thus, this study is aimed at investigating the genetic diversity of HIV-1 and DRM in Manaus. The cross-sectional study included people living with HIV on combined antiretroviral therapy and who had experienced virological failure during 2018-2019. Sequencing of the protease/reverse transcriptase (PR/RT) and C2V3 of the viral envelope gp120 (Env) regions was analyzed to determine subtypes/variants of HIV-1, DRMs, and tropism. Ninety-two individuals were analyzed in the study. Approximately 72% of them were male and 74% self-declared as heterosexual. Phylogenetic inference (PR/RT-Env) showed that most sequences were B subtype, followed by BF1 or BC mosaic genomes and few F1 and C sequences. Among the variants of subtype B at PR/RT, 84.3% were pandemic (BPAN), and 15.7% were Caribbean (BCAR). The DRMs most frequent were M184I/V (82.9%) for nucleoside reverse transcriptase inhibitors (NRTI), K103N/S (63.4%) for nonnucleoside reverse transcriptase inhibitor (NNRTI), and V82A/L/M (7.3%) for protease inhibitors (PI). DRM analysis depicted high levels of resistance for lamivudine and efavirenz in over 82.9% of individuals; although, low (7.7%) cross-resistance to etravirine was observed. A low level of resistance to protease inhibitors was found and included patients that take atazanavir/ritonavir (16.6%) and lopinavir (11.1%), which confirms that these antiretrovirals can be used—for most individuals. The thymidine analog mutations-2 (TAM-2) resistance pathway was higher in BCAR than in BPAN. Similar results from other Brazilian studies regarding HIV drug resistance were observed; however, we underscore a need for additional studies regarding subtype BCAR variants. Molecular epidemiology studies are an important tool for monitoring the prevalence of HIV drug resistance and can influence the public health policies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47861/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMOniqueLGuimarães_etal_IOC_2021.pdfMOniqueLGuimarães_etal_IOC_2021.pdfapplication/pdf818701https://www.arca.fiocruz.br/bitstream/icict/47861/2/MOniqueLGuimar%c3%a3es_etal_IOC_2021.pdf4f241378dfb6876fef476296664b320dMD52TEXTMOniqueLGuimarães_etal_IOC_2021.pdf.txtMOniqueLGuimarães_etal_IOC_2021.pdf.txtExtracted texttext/plain46396https://www.arca.fiocruz.br/bitstream/icict/47861/3/MOniqueLGuimar%c3%a3es_etal_IOC_2021.pdf.txt0c0367a15eee4f204b95f5354198a012MD53icict/478612021-06-25 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| dc.title.pt_BR.fl_str_mv |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil |
| title |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil |
| spellingShingle |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil Chaves, Yuri Oliveira Alta taxa de detecção Mutações de resistência a medicamentos Pacientes com HIV Falha na terapia antirretroviral combinada Manaus, Brasil High Detection Rate Drug Resistance Mutations Patients Failure of treatment Combined Antiretroviral Therapy Manaus, Brazil HIV |
| title_short |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil |
| title_full |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil |
| title_fullStr |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil |
| title_full_unstemmed |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil |
| title_sort |
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil |
| author |
Chaves, Yuri Oliveira |
| author_facet |
Chaves, Yuri Oliveira Pereira, Flávio Ribeiro Pinheiro, Rebeca de Souza Batista, Diego Rafael Lima Balieiro, Antônio Alcirley da Silva Lacerda, Marcus Vinicius Guimarães de Nogueira, Paulo Afonso Guimarães, Monick Lindenmeyer |
| author_role |
author |
| author2 |
Pereira, Flávio Ribeiro Pinheiro, Rebeca de Souza Batista, Diego Rafael Lima Balieiro, Antônio Alcirley da Silva Lacerda, Marcus Vinicius Guimarães de Nogueira, Paulo Afonso Guimarães, Monick Lindenmeyer |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Chaves, Yuri Oliveira Pereira, Flávio Ribeiro Pinheiro, Rebeca de Souza Batista, Diego Rafael Lima Balieiro, Antônio Alcirley da Silva Lacerda, Marcus Vinicius Guimarães de Nogueira, Paulo Afonso Guimarães, Monick Lindenmeyer |
| dc.subject.other.pt_BR.fl_str_mv |
Alta taxa de detecção Mutações de resistência a medicamentos Pacientes com HIV Falha na terapia antirretroviral combinada Manaus, Brasil |
| topic |
Alta taxa de detecção Mutações de resistência a medicamentos Pacientes com HIV Falha na terapia antirretroviral combinada Manaus, Brasil High Detection Rate Drug Resistance Mutations Patients Failure of treatment Combined Antiretroviral Therapy Manaus, Brazil HIV |
| dc.subject.en.pt_BR.fl_str_mv |
High Detection Rate Drug Resistance Mutations Patients Failure of treatment Combined Antiretroviral Therapy Manaus, Brazil HIV |
| description |
Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus. AM, Brasil. |
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2021 |
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2021-06-24T18:51:11Z |
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2021-06-24T18:51:11Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CHAVES, Yuri Oliveira et al. High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil. BioMed Resarch International, v. 2021, Article ID 5567332, 9 p, 2021. |
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https://www.arca.fiocruz.br/handle/icict/47861 |
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2314-6141 |
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10.1155/2021/5567332 |
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CHAVES, Yuri Oliveira et al. High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil. BioMed Resarch International, v. 2021, Article ID 5567332, 9 p, 2021. 2314-6141 10.1155/2021/5567332 |
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