Allele-dependent interaction of LRRK2 and NOD2 in leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58625 https://doi. org/10.1371/journal.ppat.1011260 |
Resumo: | Program in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada. / Departments of Human Genetics and Medicine. Faculty of Medicine and Health Science. McGill University. Montreal, Canada. / Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil. |
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Dallmann-Sauer, MonicaXu, Yong ZhongCosta, Ana Lúcia França daTao, ShaoGomes, Tiago AraujoPrata, Rhana Berto da SilvaCorrea- Macedo, WilianManry, JérémyAlcaïs, AlexandreAbel, LaurentCobat, AurélieFava, Vinicius M.Pinheiro, Roberta OlmoLara, Flavio AlvesProbst, Christian MacagnanMira, Marcelo T.Schurr, Erwin2023-05-24T17:14:55Z2023-05-24T17:14:55Z2023DALLMANN-SAUER, Monica et al. Allele-dependent interaction of LRRK2 and NOD2 in leprosy. PLoS Pathog, v. 19, n. 3, p. 1-32, 2023.1553-7374https://www.arca.fiocruz.br/handle/icict/58625https://doi. org/10.1371/journal.ppat.1011260porPublic Library of ScienceProteína LRRK2Leprosy, PaucibacillaryLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Nod2 Signaling Adaptor ProteinMycobacterium bovisLepra PaucibacilarProteína 2 Quinasa Serina-Treonina Rica en Repeticiones de LeucinaProteína Adaptadora de Señalización NOD2Lèpre paucibacillaireLeucine-rich repeat serine-threonine protein kinase-2Protéine adaptatrice de signalisation NOD2Hanseníase PaucibacilarSerina-Treonina Proteína Quinase-2 com Repetições Ricas em LeucinaProteína Adaptadora de Sinalização NOD2Bacillus Calmette-GuérinAllele-dependent interaction of LRRK2 and NOD2 in leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleProgram in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada. / Departments of Human Genetics and Medicine. Faculty of Medicine and Health Science. McGill University. Montreal, Canada. / Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Program in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada.Universidade Federal do Piauí. Centro de Ciências da Saúde. Departamento de Medicina Especializada. Teresina, PI, Brasil.Division of Experimental Medicine. Faculty of Medicine. McGill University. Montreal, Canada. / The Translational Research in Respiratory Diseases Program. The Research Institute of the McGill University Health Centre. Montreal, Canada.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Leprosia. Rio de Janeiro, RJ, Brasil.Program in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada. / Department of Biochemistry. Faculty of Medicine and Health Science. McGill University. Montreal, Canada.Program in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada.Laboratory of Human Genetics of Infectious Diseases. Necker Branch. Institut National de la Santé et de la Recherche Médicale. Paris, France. / Université Paris Cité. Imagine Institute. Paris, France.Laboratory of Human Genetics of Infectious Diseases. Necker Branch. Institut National de la Santé et de la Recherche Médicale. Paris, France. / Université Paris Cité. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University. New York, United States of America.Laboratory of Human Genetics of Infectious Diseases. Necker Branch. Institut National de la Santé et de la Recherche Médicale. Paris, France. / Université Paris Cité. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University. New York, United States of America.Program in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Leprosia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Program in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada. / Department of Biochemistry. Faculty of Medicine and Health Science. McGill University. Montreal, Canada.Leprosy, caused by Mycobacterium leprae, rarely affects children younger than 5 years. Here, we studied a multiplex leprosy family that included monozygotic twins aged 22 months suffering from paucibacillary leprosy. Whole genome sequencing identified three amino acid mutations previously associated with Crohn’s disease and Parkinson’s disease as candidate variants for early onset leprosy: LRRK2 N551K, R1398H and NOD2 R702W. In genome-edited macrophages, we demonstrated that cells expressing the LRRK2 mutations displayed reduced apoptosis activity following mycobacterial challenge independently of NOD2. However, employing co-immunoprecipitation and confocal microscopy we showed that LRRK2 and NOD2 proteins interacted in RAW cells and monocyte-derived macrophages, and that this interaction was substantially reduced for the NOD2 R702W mutation. Moreover, we observed a joint effect of LRRK2 and NOD2 variants on Bacillus Calmette-Guérin (BCG)-induced respiratory burst, NF-κB activation and cytokine/chemokine secretion with a strong impact for the genotypes found in the twins consistent with a role of the identified mutations in the development of early onset leprosy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58625/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALppat.1011260OK.pdfppat.1011260OK.pdfapplication/pdf2529147https://www.arca.fiocruz.br/bitstream/icict/58625/2/ppat.1011260OK.pdfb0c40d171c99485ebcfdc89a73ba360fMD52icict/586252023-05-24 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| dc.title.en_US.fl_str_mv |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy |
| title |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy |
| spellingShingle |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy Dallmann-Sauer, Monica Proteína LRRK2 Leprosy, Paucibacillary Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Nod2 Signaling Adaptor Protein Mycobacterium bovis Lepra Paucibacilar Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Proteína Adaptadora de Señalización NOD2 Lèpre paucibacillaire Leucine-rich repeat serine-threonine protein kinase-2 Protéine adaptatrice de signalisation NOD2 Hanseníase Paucibacilar Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Proteína Adaptadora de Sinalização NOD2 Bacillus Calmette-Guérin |
| title_short |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy |
| title_full |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy |
| title_fullStr |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy |
| title_full_unstemmed |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy |
| title_sort |
Allele-dependent interaction of LRRK2 and NOD2 in leprosy |
| author |
Dallmann-Sauer, Monica |
| author_facet |
Dallmann-Sauer, Monica Xu, Yong Zhong Costa, Ana Lúcia França da Tao, Shao Gomes, Tiago Araujo Prata, Rhana Berto da Silva Correa- Macedo, Wilian Manry, Jérémy Alcaïs, Alexandre Abel, Laurent Cobat, Aurélie Fava, Vinicius M. Pinheiro, Roberta Olmo Lara, Flavio Alves Probst, Christian Macagnan Mira, Marcelo T. Schurr, Erwin |
| author_role |
author |
| author2 |
Xu, Yong Zhong Costa, Ana Lúcia França da Tao, Shao Gomes, Tiago Araujo Prata, Rhana Berto da Silva Correa- Macedo, Wilian Manry, Jérémy Alcaïs, Alexandre Abel, Laurent Cobat, Aurélie Fava, Vinicius M. Pinheiro, Roberta Olmo Lara, Flavio Alves Probst, Christian Macagnan Mira, Marcelo T. Schurr, Erwin |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Dallmann-Sauer, Monica Xu, Yong Zhong Costa, Ana Lúcia França da Tao, Shao Gomes, Tiago Araujo Prata, Rhana Berto da Silva Correa- Macedo, Wilian Manry, Jérémy Alcaïs, Alexandre Abel, Laurent Cobat, Aurélie Fava, Vinicius M. Pinheiro, Roberta Olmo Lara, Flavio Alves Probst, Christian Macagnan Mira, Marcelo T. Schurr, Erwin |
| dc.subject.other.en_US.fl_str_mv |
Proteína LRRK2 |
| topic |
Proteína LRRK2 Leprosy, Paucibacillary Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Nod2 Signaling Adaptor Protein Mycobacterium bovis Lepra Paucibacilar Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Proteína Adaptadora de Señalización NOD2 Lèpre paucibacillaire Leucine-rich repeat serine-threonine protein kinase-2 Protéine adaptatrice de signalisation NOD2 Hanseníase Paucibacilar Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Proteína Adaptadora de Sinalização NOD2 Bacillus Calmette-Guérin |
| dc.subject.en.en_US.fl_str_mv |
Leprosy, Paucibacillary Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Nod2 Signaling Adaptor Protein Mycobacterium bovis |
| dc.subject.es.en_US.fl_str_mv |
Lepra Paucibacilar Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Proteína Adaptadora de Señalización NOD2 |
| dc.subject.fr.en_US.fl_str_mv |
Lèpre paucibacillaire Leucine-rich repeat serine-threonine protein kinase-2 Protéine adaptatrice de signalisation NOD2 |
| dc.subject.decs.en_US.fl_str_mv |
Hanseníase Paucibacilar Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Proteína Adaptadora de Sinalização NOD2 Bacillus Calmette-Guérin |
| description |
Program in Infectious Diseases and Immunity in Global Health. The Research Institute of the McGill University Health Centre. Montreal, Canada. / McGill International TB Centre. McGill University. Montreal, Canada. / Departments of Human Genetics and Medicine. Faculty of Medicine and Health Science. McGill University. Montreal, Canada. / Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil. |
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2023 |
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2023-05-24T17:14:55Z |
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2023-05-24T17:14:55Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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| dc.identifier.citation.fl_str_mv |
DALLMANN-SAUER, Monica et al. Allele-dependent interaction of LRRK2 and NOD2 in leprosy. PLoS Pathog, v. 19, n. 3, p. 1-32, 2023. |
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https://www.arca.fiocruz.br/handle/icict/58625 |
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1553-7374 |
| dc.identifier.doi.none.fl_str_mv |
https://doi. org/10.1371/journal.ppat.1011260 |
| identifier_str_mv |
DALLMANN-SAUER, Monica et al. Allele-dependent interaction of LRRK2 and NOD2 in leprosy. PLoS Pathog, v. 19, n. 3, p. 1-32, 2023. 1553-7374 |
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https://www.arca.fiocruz.br/handle/icict/58625 https://doi. org/10.1371/journal.ppat.1011260 |
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