Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.

Bibliographic Details
Main Author: Figueiredo, Camila Alexandrina Viana
Publication Date: 2011
Other Authors: Neves, Neuza Maria Alcântara, Amorim, Leila D, Silva, Nivea B, Pontes-de-Carvalho, Lain Carlos, Cooper, Philip John, Rodrigues, Laura Cunha, Barreto, Maurício Lima
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/8281
Summary: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
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spelling Figueiredo, Camila Alexandrina VianaNeves, Neuza Maria AlcântaraAmorim, Leila DSilva, Nivea BPontes-de-Carvalho, Lain CarlosCooper, Philip JohnRodrigues, Laura CunhaBarreto, Maurício Lima2014-08-27T18:59:53Z2014-08-27T18:59:53Z2011FIGUEIREDO, C. A. et al. Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment. Clinical Immunology, v. 139, n. 1, p. 57-64, 2011.1521-703510.1016/j.clim.2010.12.019https://www.arca.fiocruz.br/handle/icict/8281engElsevierEvidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Matemática. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Matemática. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidad San Francisco de Quito. Quito, Ecuador / University of London. Centre for Infection. St George's. London, UKLondon School of Hygiene and Tropical Medicine. London, UKUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilAllergic and other immune-mediated diseases are complex disease states determined by interplay between host genetics and environmental factors. Environmental changes such as fewer infections and reduced exposure to microbial products have been suggested to have led to insufficient regulation of Th1 and Th2 immune responses, causing an increased incidence of inflammatory diseases. The objective of the present study was to investigate the effect of poor living environmental conditions on mitogen-induced production of cytokines (Th1 and Th2) by peripheral blood leukocytes in children living in urban Brazil and investigate the role of IL-10 in modifying this effect. Our data showed that the proportion of children producing Th1 and Th2 cytokines was lower among those with poor living conditions and that this finding was stronger in children producing IL-10. These results provide a possible biologic explanation for the temporal trends of increasing risk of inflammatory diseases observed in populations living in affluent countries.IL-10Th1/Th2EnvironmentSewage systemStreet pavingImmune regulationCitocinas/metabolismoHabitaçãoInterleucina-10/farmacologiaCélulas Th1/metabolismoBrasil/epidemiologiaCélulas CultivadasCriançaPré-EscolarFemininoRegulação da Expressão Gênica/efeitos de drogasHumanosHipersensibilidade/epidemiologiaFatores de RiscoMasculinoFatores Socioeconômicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8281/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALFigueiredo Camila A. Evidence for a modulatory.....pdfFigueiredo Camila A. 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dc.title.pt_BR.fl_str_mv Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
title Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
spellingShingle Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
Figueiredo, Camila Alexandrina Viana
IL-10
Th1/Th2
Environment
Sewage system
Street paving
Immune regulation
Citocinas/metabolismo
Habitação
Interleucina-10/farmacologia
Células Th1/metabolismo
Brasil/epidemiologia
Células Cultivadas
Criança
Pré-Escolar
Feminino
Regulação da Expressão Gênica/efeitos de drogas
Humanos
Hipersensibilidade/epidemiologia
Fatores de Risco
Masculino
Fatores Socioeconômicos
title_short Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
title_full Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
title_fullStr Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
title_full_unstemmed Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
title_sort Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
author Figueiredo, Camila Alexandrina Viana
author_facet Figueiredo, Camila Alexandrina Viana
Neves, Neuza Maria Alcântara
Amorim, Leila D
Silva, Nivea B
Pontes-de-Carvalho, Lain Carlos
Cooper, Philip John
Rodrigues, Laura Cunha
Barreto, Maurício Lima
author_role author
author2 Neves, Neuza Maria Alcântara
Amorim, Leila D
Silva, Nivea B
Pontes-de-Carvalho, Lain Carlos
Cooper, Philip John
Rodrigues, Laura Cunha
Barreto, Maurício Lima
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo, Camila Alexandrina Viana
Neves, Neuza Maria Alcântara
Amorim, Leila D
Silva, Nivea B
Pontes-de-Carvalho, Lain Carlos
Cooper, Philip John
Rodrigues, Laura Cunha
Barreto, Maurício Lima
dc.subject.en.pt_BR.fl_str_mv IL-10
Th1/Th2
Environment
Sewage system
Street paving
Immune regulation
topic IL-10
Th1/Th2
Environment
Sewage system
Street paving
Immune regulation
Citocinas/metabolismo
Habitação
Interleucina-10/farmacologia
Células Th1/metabolismo
Brasil/epidemiologia
Células Cultivadas
Criança
Pré-Escolar
Feminino
Regulação da Expressão Gênica/efeitos de drogas
Humanos
Hipersensibilidade/epidemiologia
Fatores de Risco
Masculino
Fatores Socioeconômicos
dc.subject.decs.pt_BR.fl_str_mv Citocinas/metabolismo
Habitação
Interleucina-10/farmacologia
Células Th1/metabolismo
Brasil/epidemiologia
Células Cultivadas
Criança
Pré-Escolar
Feminino
Regulação da Expressão Gênica/efeitos de drogas
Humanos
Hipersensibilidade/epidemiologia
Fatores de Risco
Masculino
Fatores Socioeconômicos
description Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-08-27T18:59:53Z
dc.date.available.fl_str_mv 2014-08-27T18:59:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FIGUEIREDO, C. A. et al. Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment. Clinical Immunology, v. 139, n. 1, p. 57-64, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8281
dc.identifier.issn.none.fl_str_mv 1521-7035
10.1016/j.clim.2010.12.019
identifier_str_mv FIGUEIREDO, C. A. et al. Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment. Clinical Immunology, v. 139, n. 1, p. 57-64, 2011.
1521-7035
10.1016/j.clim.2010.12.019
url https://www.arca.fiocruz.br/handle/icict/8281
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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