Metal Nanoparticles to Combat Candida albicans Infections

Bibliographic Details
Main Author: Carmo, Paulo Henrique Fonseca do
Publication Date: 2023
Other Authors: Garcia, Maíra Terra, Figueiredo-Godoi, Lívia Mara Alves, Lage, Anna Carolina Pinheiro, Silva, Newton Soares da, Junqueira, Juliana Campos
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/57043
Summary: Department of Biosciences and Oral Diagnosis. Institute of Science and Technology. São Paulo State University. São José dos Campos, SP, Brazil.
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spelling Carmo, Paulo Henrique Fonseca doGarcia, Maíra TerraFigueiredo-Godoi, Lívia Mara AlvesLage, Anna Carolina PinheiroSilva, Newton Soares daJunqueira, Juliana Campos2023-02-13T17:19:52Z2023-02-13T17:19:52Z2023CARMO, Paulo Henrique Fonseca do et al. Metal Nanoparticles to Combat Candida albicans Infections: An Update. Microorganisms, v. 11, p. 1-19, 2023.2076-2607https://www.arca.fiocruz.br/handle/icict/5704310.3390/microorganisms11010138engMDPIMetal Nanoparticles to Combat Candida albicans Infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Biosciences and Oral Diagnosis. Institute of Science and Technology. São Paulo State University. São José dos Campos, SP, Brazil.Department of Biosciences and Oral Diagnosis. Institute of Science and Technology. São Paulo State University. São José dos Campos, SP, Brazil.Department of Biosciences and Oral Diagnosis. Institute of Science and Technology. São Paulo State University. São José dos Campos, SP, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Department of Environmental Engineering. Institute of Science and Technology, São Paulo State University. São José dos Campos, SP, Brazil.Department of Biosciences and Oral Diagnosis. Institute of Science and Technology. São Paulo State University. São José dos Campos, SP, Brazil.Candidiasis is an opportunistic mycosis with high annual incidence worldwide. In these infections, Candida albicans is the chief pathogen owing to its multiple virulence factors. C. albicans infections are usually treated with azoles, polyenes and echinocandins. However, these antifungals may have limitations regarding toxicity, relapse of infections, high cost, and emergence of antifungal resistance. Thus, the development of nanocarrier systems, such as metal nanoparticles, has been widely investigated. Metal nanoparticles are particulate dispersions or solid particles 10-100 nm in size, with unique physical and chemical properties that make them useful in biomedical applications. In this review, we focus on the activity of silver, gold, and iron nanoparticles against C. albicans. We discuss the use of metal nanoparticles as delivery vehicles for antifungal drugs or natural compounds to increase their biocompatibility and effectiveness. Promisingly, most of these nanoparticles exhibit potential antifungal activity through multi-target mechanisms in C. albicans cells and biofilms, which can minimize the emergence of antifungal resistance. The cytotoxicity of metal nanoparticles is a concern, and adjustments in synthesis approaches or coating techniques have been addressed to overcome these limitations, with great emphasis on green synthesis.Candida albicansAntifungal agentGoldIronMetal nanoparticlesSilverinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57043/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMetal Nanoparticles to Combat Candida albicans Infections_ An Update - microorganisms-11-00138.pdfMetal Nanoparticles to Combat Candida albicans Infections_ An Update - microorganisms-11-00138.pdfapplication/pdf9532415https://www.arca.fiocruz.br/bitstream/icict/57043/2/Metal%20Nanoparticles%20to%20Combat%20Candida%20albicans%20Infections_%20An%20Update%20-%20microorganisms-11-00138.pdfca3d7404f4feb622c6e1695fc8b76254MD52icict/570432023-05-26 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dc.title.en_US.fl_str_mv Metal Nanoparticles to Combat Candida albicans Infections
title Metal Nanoparticles to Combat Candida albicans Infections
spellingShingle Metal Nanoparticles to Combat Candida albicans Infections
Carmo, Paulo Henrique Fonseca do
Candida albicans
Antifungal agent
Gold
Iron
Metal nanoparticles
Silver
title_short Metal Nanoparticles to Combat Candida albicans Infections
title_full Metal Nanoparticles to Combat Candida albicans Infections
title_fullStr Metal Nanoparticles to Combat Candida albicans Infections
title_full_unstemmed Metal Nanoparticles to Combat Candida albicans Infections
title_sort Metal Nanoparticles to Combat Candida albicans Infections
author Carmo, Paulo Henrique Fonseca do
author_facet Carmo, Paulo Henrique Fonseca do
Garcia, Maíra Terra
Figueiredo-Godoi, Lívia Mara Alves
Lage, Anna Carolina Pinheiro
Silva, Newton Soares da
Junqueira, Juliana Campos
author_role author
author2 Garcia, Maíra Terra
Figueiredo-Godoi, Lívia Mara Alves
Lage, Anna Carolina Pinheiro
Silva, Newton Soares da
Junqueira, Juliana Campos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carmo, Paulo Henrique Fonseca do
Garcia, Maíra Terra
Figueiredo-Godoi, Lívia Mara Alves
Lage, Anna Carolina Pinheiro
Silva, Newton Soares da
Junqueira, Juliana Campos
dc.subject.en.en_US.fl_str_mv Candida albicans
Antifungal agent
Gold
Iron
Metal nanoparticles
Silver
topic Candida albicans
Antifungal agent
Gold
Iron
Metal nanoparticles
Silver
description Department of Biosciences and Oral Diagnosis. Institute of Science and Technology. São Paulo State University. São José dos Campos, SP, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-02-13T17:19:52Z
dc.date.available.fl_str_mv 2023-02-13T17:19:52Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARMO, Paulo Henrique Fonseca do et al. Metal Nanoparticles to Combat Candida albicans Infections: An Update. Microorganisms, v. 11, p. 1-19, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57043
dc.identifier.issn.en_US.fl_str_mv 2076-2607
dc.identifier.doi.none.fl_str_mv 10.3390/microorganisms11010138
identifier_str_mv CARMO, Paulo Henrique Fonseca do et al. Metal Nanoparticles to Combat Candida albicans Infections: An Update. Microorganisms, v. 11, p. 1-19, 2023.
2076-2607
10.3390/microorganisms11010138
url https://www.arca.fiocruz.br/handle/icict/57043
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57043/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57043/2/Metal%20Nanoparticles%20to%20Combat%20Candida%20albicans%20Infections_%20An%20Update%20-%20microorganisms-11-00138.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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