Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria

Detalhes bibliográficos
Autor(a) principal: Kano, Flora Satiko
Data de Publicação: 2018
Outros Autores: Souza, Aracele Maria de, Torres, Leticia de Menezes, Costa, Marcelo Azevedo, Silva, Flávia Alessandra Souza, Sanchez, Bruno Antônio Marinho, Fontes, Cor Jesus Fernandes, Soares, Irene Silva, Brito, Cristiana Ferreira Alves de, Carvalho, Luzia Helena de, Sousa, Tais Nobrega
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33634
Resumo: Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.
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spelling Kano, Flora SatikoSouza, Aracele Maria deTorres, Leticia de MenezesCosta, Marcelo AzevedoSilva, Flávia Alessandra SouzaSanchez, Bruno Antônio MarinhoFontes, Cor Jesus FernandesSoares, Irene SilvaBrito, Cristiana Ferreira Alves deCarvalho, Luzia Helena deSousa, Tais Nobrega2019-06-24T16:24:09Z2019-06-24T16:24:09Z2018KANO, Flora Satiko et al. Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria. Scientific Reports, v. 8, p. 1-14, 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/3363410.1038/s41598-018-32254-zengNature Researchbiologia parasitariainteração hospedeiro parasitaParasite biologyParasite host responseSusceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Engenharia de Produção. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Universidade Federal de Mato Grosso. Cuiabá, MT, Brasil.Universidade Federal de Mato Grosso. Hospital Julio Muller. Cuiabá, MT, Brazil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Malaria has provided a major selective pressure and has modulated the genetic diversity of the human genome. The variants of the Duffy Antigen/Receptor for Chemokines (DARC) gene have probably been selected by malaria parasites, particularly the FY*O allele, which is fixed in sub-Saharan Africa and confers resistance to Plasmodium vivax infection. Here, we showed the influence of genomic ancestry on the distribution of DARC genotypes in a highly admixed Brazilian population and confirmed the decreased susceptibility of the FY*A/FY*O genotype to clinical P. vivax malaria. FY*B/FY*O individuals were associated with a greater risk of developing clinical malaria. A remarkable difference among DARC variants concerning the susceptibility to clinical malaria was more evident for individuals who were less exposed to malaria, as measured by the time of residence in the endemic area. Additionally, we found that DARC-negative and FY*A/FY*O individuals had a greater chance of acquiring high levels of antibodies against the 19-kDa C-terminal region of the P. vivax merozoite surface protein-1. Altogether, our results provide evidence that DARC polymorphisms modulate the susceptibility to clinical P. vivax malaria and influence the naturally-acquired humoral immune response to malaria blood antigens, which may interfere with the efficacy of a future vaccine against malaria.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/33634/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALSusceptibility to Plasmodium vivax malaria.pdfSusceptibility to Plasmodium vivax malaria.pdfapplication/pdf1166943https://www.arca.fiocruz.br/bitstream/icict/33634/2/Susceptibility%20to%20Plasmodium%20vivax%20malaria.pdf8c68739c4ccbf3121183fed31318881bMD52TEXTSusceptibility to Plasmodium vivax malaria.pdf.txtSusceptibility to Plasmodium vivax malaria.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
title Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
spellingShingle Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
Kano, Flora Satiko
biologia parasitaria
interação hospedeiro parasita
Parasite biology
Parasite host response
title_short Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
title_full Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
title_fullStr Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
title_full_unstemmed Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
title_sort Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
author Kano, Flora Satiko
author_facet Kano, Flora Satiko
Souza, Aracele Maria de
Torres, Leticia de Menezes
Costa, Marcelo Azevedo
Silva, Flávia Alessandra Souza
Sanchez, Bruno Antônio Marinho
Fontes, Cor Jesus Fernandes
Soares, Irene Silva
Brito, Cristiana Ferreira Alves de
Carvalho, Luzia Helena de
Sousa, Tais Nobrega
author_role author
author2 Souza, Aracele Maria de
Torres, Leticia de Menezes
Costa, Marcelo Azevedo
Silva, Flávia Alessandra Souza
Sanchez, Bruno Antônio Marinho
Fontes, Cor Jesus Fernandes
Soares, Irene Silva
Brito, Cristiana Ferreira Alves de
Carvalho, Luzia Helena de
Sousa, Tais Nobrega
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kano, Flora Satiko
Souza, Aracele Maria de
Torres, Leticia de Menezes
Costa, Marcelo Azevedo
Silva, Flávia Alessandra Souza
Sanchez, Bruno Antônio Marinho
Fontes, Cor Jesus Fernandes
Soares, Irene Silva
Brito, Cristiana Ferreira Alves de
Carvalho, Luzia Helena de
Sousa, Tais Nobrega
dc.subject.other.pt_BR.fl_str_mv biologia parasitaria
interação hospedeiro parasita
topic biologia parasitaria
interação hospedeiro parasita
Parasite biology
Parasite host response
dc.subject.en.pt_BR.fl_str_mv Parasite biology
Parasite host response
description Fundação Oswaldo Cruz. Instituto Rene Rachou. Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-06-24T16:24:09Z
dc.date.available.fl_str_mv 2019-06-24T16:24:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KANO, Flora Satiko et al. Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria. Scientific Reports, v. 8, p. 1-14, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33634
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-018-32254-z
identifier_str_mv KANO, Flora Satiko et al. Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria. Scientific Reports, v. 8, p. 1-14, 2018.
2045-2322
10.1038/s41598-018-32254-z
url https://www.arca.fiocruz.br/handle/icict/33634
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33634/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33634/2/Susceptibility%20to%20Plasmodium%20vivax%20malaria.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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