Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals

Detalhes bibliográficos
Autor(a) principal: Brito, Carlos Alexandre Antunes de
Data de Publicação: 2020
Outros Autores: Marques, Claudia Diniz Lopes, França, Rafael Freitas de Oliveira, Monteiro, Janaína Gomes Ratis, Brito, Marina Coelho Moraes de, Lopes, Fabiana, Lima, Anton, Marques, Gabriel L., Valadares, Maria Luisa David de Azevedo, Duarte, Angela Luzia Branco Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45462
Resumo: Universidade Federal de Pernambuco. Hospital das Clínicas. Clínica Médica. Recife, PE, Brasil / Instituto Autoimune de Pesquisa e Educação Continuada. Recife, PE, Brasil.
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spelling Brito, Carlos Alexandre Antunes deMarques, Claudia Diniz LopesFrança, Rafael Freitas de OliveiraMonteiro, Janaína Gomes RatisBrito, Marina Coelho Moraes deLopes, FabianaLima, AntonMarques, Gabriel L.Valadares, Maria Luisa David de AzevedoDuarte, Angela Luzia Branco Pinto2020-12-29T14:17:44Z2020-12-29T14:17:44Z2020BRITO, Carlos Alexandre Antunes de et al. Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals. Journal of Tropical Medicine, v. 2020, p. 1-6, 10 Jul. 2020.1687-9686https://www.arca.fiocruz.br/handle/icict/4546210.1155/2020/20713251687-9694engHindawiReduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicalsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Hospital das Clínicas. Clínica Médica. Recife, PE, Brasil / Instituto Autoimune de Pesquisa e Educação Continuada. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Serviço de Reumatologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Católica de Pernambuco. Recife, PE, Brasil.Faculdade de Medicina de Olinda. Olinda, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Serviço de Reumatologia. Recife, PE, Brasil.Chikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients. This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls. Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls (p = 0.79). Of those with positive serology, 32 (76%) and 14 (93%) were symptomatic among subjects in the bDMARD and control groups, respectively (p = 0.87). Persistence of musculoskeletal symptoms for more than three months occurred in 64% of the patients in the control group and only in 28% in the bDMARD group (p = 0.021), maintaining a statistically significant difference only for users of anti-TNF. This study found that patients affected by chikungunya fever using bDMARDs did not present severe forms or complications in the acute phase of the disease, and patients using anti-TNF biologicals had a lower frequency of chronic joint symptoms than the household controls. This favorable outcome may be related to the cytokine blockade, with a reduction in the inflammatory response and joint damage.Chikungunya feverChronic symptomsMusculoskeletal painAutoimmune inflammatory diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83132https://www.arca.fiocruz.br/bitstream/icict/45462/1/license.txt33967fcc8ef681b8f5c2c34178ebc114MD51ORIGINALBrito_Carlos_etal_IAM_2020.pdfBrito_Carlos_etal_IAM_2020.pdfapplication/pdf401437https://www.arca.fiocruz.br/bitstream/icict/45462/2/Brito_Carlos_etal_IAM_2020.pdf79a00723b06ce84513981819648f7de9MD52TEXTBrito_Carlos_etal_IAM_2020.pdf.txtBrito_Carlos_etal_IAM_2020.pdf.txtExtracted texttext/plain29175https://www.arca.fiocruz.br/bitstream/icict/45462/3/Brito_Carlos_etal_IAM_2020.pdf.txt9fb1d617c23b10c3786ac2d437e8cbecMD53icict/454622020-12-31 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dc.title.pt_BR.fl_str_mv Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
title Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
spellingShingle Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
Brito, Carlos Alexandre Antunes de
Chikungunya fever
Chronic symptoms
Musculoskeletal pain
Autoimmune inflammatory disease
title_short Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
title_full Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
title_fullStr Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
title_full_unstemmed Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
title_sort Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
author Brito, Carlos Alexandre Antunes de
author_facet Brito, Carlos Alexandre Antunes de
Marques, Claudia Diniz Lopes
França, Rafael Freitas de Oliveira
Monteiro, Janaína Gomes Ratis
Brito, Marina Coelho Moraes de
Lopes, Fabiana
Lima, Anton
Marques, Gabriel L.
Valadares, Maria Luisa David de Azevedo
Duarte, Angela Luzia Branco Pinto
author_role author
author2 Marques, Claudia Diniz Lopes
França, Rafael Freitas de Oliveira
Monteiro, Janaína Gomes Ratis
Brito, Marina Coelho Moraes de
Lopes, Fabiana
Lima, Anton
Marques, Gabriel L.
Valadares, Maria Luisa David de Azevedo
Duarte, Angela Luzia Branco Pinto
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brito, Carlos Alexandre Antunes de
Marques, Claudia Diniz Lopes
França, Rafael Freitas de Oliveira
Monteiro, Janaína Gomes Ratis
Brito, Marina Coelho Moraes de
Lopes, Fabiana
Lima, Anton
Marques, Gabriel L.
Valadares, Maria Luisa David de Azevedo
Duarte, Angela Luzia Branco Pinto
dc.subject.en.en.fl_str_mv Chikungunya fever
Chronic symptoms
Musculoskeletal pain
Autoimmune inflammatory disease
topic Chikungunya fever
Chronic symptoms
Musculoskeletal pain
Autoimmune inflammatory disease
description Universidade Federal de Pernambuco. Hospital das Clínicas. Clínica Médica. Recife, PE, Brasil / Instituto Autoimune de Pesquisa e Educação Continuada. Recife, PE, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-12-29T14:17:44Z
dc.date.available.fl_str_mv 2020-12-29T14:17:44Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRITO, Carlos Alexandre Antunes de et al. Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals. Journal of Tropical Medicine, v. 2020, p. 1-6, 10 Jul. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45462
dc.identifier.issn.pt_BR.fl_str_mv 1687-9686
dc.identifier.doi.none.fl_str_mv 10.1155/2020/2071325
dc.identifier.eissn.none.fl_str_mv 1687-9694
identifier_str_mv BRITO, Carlos Alexandre Antunes de et al. Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals. Journal of Tropical Medicine, v. 2020, p. 1-6, 10 Jul. 2020.
1687-9686
10.1155/2020/2071325
1687-9694
url https://www.arca.fiocruz.br/handle/icict/45462
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/45462/1/license.txt
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