Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children

Bibliographic Details
Main Author: Zhao, Ziqi
Publication Date: 2020
Other Authors: Shang, Ziwei, Vasconcelos, Zilton Farias Meira de, Li, Chunfeng, Jiang, Yisheng, Zu, Shulong, Zhang, Jingyi, Wang, Fengchao, Yao, Li, Jung, Jae U., Brasil, Patricia, Moreira, Maria Elisabeth, Qin, Cheng-Feng, Kerin, Tara, Nielsen-Saines, Karin, Cheng, Genhong, Zhang, Xiaohui, Xu, Zhiheng
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/43964
Summary: Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology. Neijing, China.
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spelling Zhao, ZiqiShang, ZiweiVasconcelos, Zilton Farias Meira deLi, ChunfengJiang, YishengZu, ShulongZhang, JingyiWang, FengchaoYao, LiJung, Jae U.Brasil, PatriciaMoreira, Maria ElisabethQin, Cheng-FengKerin, TaraNielsen-Saines, KarinCheng, GenhongZhang, XiaohuiXu, Zhiheng2020-10-13T14:52:26Z2020-10-13T14:52:26Z2020ZHAO, Ziqi et al. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, v. 7, n. 18, p. 1-10, 2020.2198-3844https://www.arca.fiocruz.br/handle/icict/4396410.1002/advs.201901996engWileyZika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology. Neijing, China.Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Stanford University. Institute for Immunity Transplantation and Infection. Stanford, CA, USA.Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology. Neijing, China.Chinese Academy of Medical Sciences & Peking Union Medical College. Institute of Basic Medical Sciences. Center for Systems Medicine. Beijing, China / Suzhou Institute of Systems Medicine. Suzhou, Jiangsu, China.Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Obstetrics and Gynecology. Department of Molecular Microbiology and Immunology and Division of Maternal-Fetal Medicine. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Beijing Institute of Microbiology and Epidemiology. State Key Laboratory of Pathogen and Biosecurity. Department of Virology. Beijing, China.UCLA. Mattel Children’s Hospital. David Geffen School of Medicine. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.UCLA. Mattel Children’s Hospital. David Geffen School of Medicine. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.Chinese Academy of Medical Sciences & Peking Union Medical College. Institute of Basic Medical Sciences. Center for Systems Medicine. Beijing, China / Suzhou Institute of Systems Medicine. Suzhou, Jiangsu, China / University of California. Department of Microbiology Immunology and Molecular Genetics. Los Angeles, CA, USA.Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology / Parkinson's Disease Center Beijing Institute for Brain Disorders. Beijing, China.Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience-dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood.Zika virusAbnormal behaviorsMicrocephalyNeurological functionsVisual cortical functionsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/43964/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALpatricia_brasil_et_all.pdfapplication/pdf13687362https://www.arca.fiocruz.br/bitstream/icict/43964/2/patricia_brasil_et_all.pdfb7675b42f9987b640ce4029ba9a61f2cMD52TEXTpatricia_brasil_et_all.pdf.txtpatricia_brasil_et_all.pdf.txtExtracted texttext/plain37088https://www.arca.fiocruz.br/bitstream/icict/43964/3/patricia_brasil_et_all.pdf.txt097cb1d34bcacd22e67190f90054864fMD53icict/439642020-12-02 22:32:21.373oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-12-03T01:32:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
spellingShingle Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
Zhao, Ziqi
Zika virus
Abnormal behaviors
Microcephaly
Neurological functions
Visual cortical functions
title_short Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_full Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_fullStr Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_full_unstemmed Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_sort Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
author Zhao, Ziqi
author_facet Zhao, Ziqi
Shang, Ziwei
Vasconcelos, Zilton Farias Meira de
Li, Chunfeng
Jiang, Yisheng
Zu, Shulong
Zhang, Jingyi
Wang, Fengchao
Yao, Li
Jung, Jae U.
Brasil, Patricia
Moreira, Maria Elisabeth
Qin, Cheng-Feng
Kerin, Tara
Nielsen-Saines, Karin
Cheng, Genhong
Zhang, Xiaohui
Xu, Zhiheng
author_role author
author2 Shang, Ziwei
Vasconcelos, Zilton Farias Meira de
Li, Chunfeng
Jiang, Yisheng
Zu, Shulong
Zhang, Jingyi
Wang, Fengchao
Yao, Li
Jung, Jae U.
Brasil, Patricia
Moreira, Maria Elisabeth
Qin, Cheng-Feng
Kerin, Tara
Nielsen-Saines, Karin
Cheng, Genhong
Zhang, Xiaohui
Xu, Zhiheng
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zhao, Ziqi
Shang, Ziwei
Vasconcelos, Zilton Farias Meira de
Li, Chunfeng
Jiang, Yisheng
Zu, Shulong
Zhang, Jingyi
Wang, Fengchao
Yao, Li
Jung, Jae U.
Brasil, Patricia
Moreira, Maria Elisabeth
Qin, Cheng-Feng
Kerin, Tara
Nielsen-Saines, Karin
Cheng, Genhong
Zhang, Xiaohui
Xu, Zhiheng
dc.subject.en.pt_BR.fl_str_mv Zika virus
Abnormal behaviors
Microcephaly
Neurological functions
Visual cortical functions
topic Zika virus
Abnormal behaviors
Microcephaly
Neurological functions
Visual cortical functions
description Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology. Neijing, China.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-13T14:52:26Z
dc.date.available.fl_str_mv 2020-10-13T14:52:26Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZHAO, Ziqi et al. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, v. 7, n. 18, p. 1-10, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43964
dc.identifier.issn.pt_BR.fl_str_mv 2198-3844
dc.identifier.doi.none.fl_str_mv 10.1002/advs.201901996
identifier_str_mv ZHAO, Ziqi et al. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, v. 7, n. 18, p. 1-10, 2020.
2198-3844
10.1002/advs.201901996
url https://www.arca.fiocruz.br/handle/icict/43964
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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