Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study

Detalhes bibliográficos
Autor(a) principal: Cavalcanti, A.
Data de Publicação: 2017
Outros Autores: Santos, R., Mesquita, Z., Duarte, A. L. B. P., Lucena-Silva, N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19475
Resumo: Universidade Federal de Pernambuco. Hospital das Clínicas. Unidade de Reumatologia. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
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spelling Cavalcanti, A.Santos, R.Mesquita, Z.Duarte, A. L. B. P.Lucena-Silva, N.2017-06-21T17:58:17Z2017-06-21T17:58:17Z2017CAVALCANTI, A. et al. Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study. Brazilian Journal of Medical and Biological Research, v. 50, n. 4, 2017.1414-431Xhttps://www.arca.fiocruz.br/handle/icict/1947510.1590/1414-431X20175738engCitocinasLúpus eritematoso sistêmico de início na infânciaAtividade de doençaSLEDAI-2KInflamaçãoCytokinesChildhood-onset systemic lupus erythematosusDisease activitySLEDAI-2KInflammationLúpus Eritematoso Sistémico , Sistémico / sangueCitocinas / sangueCytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Hospital das Clínicas. Unidade de Reumatologia. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Instituto de Medicina Integral Professor Fernando Figueira. Unidade de Reumatologia Pediátrica. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Unidade de Reumatologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira. Unidade de Oncologia Pediátrica. Recife, PE, Brasil.Childhood-onset systemic lupus erythematosus (cSLE) exhibits an aggressive clinical phenotype and severe complications. This could be due to a pro-inflammatory cytokine milieu. Therefore, we determined plasma levels of Th1 (IL-2, IFN-γ, TNF), Th2 (IL-4), Th17 (IL-17A, IL-6), and Treg (IL-10) cytokines in a cohort of cSLE patients and healthy controls, and we evaluated the association between these cytokines and disease activity. We conducted a cross-sectional study with 51 cSLE patients from two pediatric rheumatology services. Ten cSLE patients participated in a longitudinal follow-up study. Blood samples were collected from the same patient during active and inactive disease. Disease activity was evaluated according to SLE Disease Activity Index 2000 (SLEDAI-2K). Cytokines levels were measured by cytometric bead array technique. cSLE patients had higher IL-6 (P<0.001) and IL-10 (P<0.001) levels than healthy controls. Patients with active disease had higher IL-6 and IL-10 levels than patients with inactive disease (P=0.001 and P=0.014, respectively) and the control group (both P<0.001). IL-6 (P=0.022), IL-10 (P=0.013), and IL-17A (P=0.041) levels were significantly higher during active than inactive disease. Linear regression analysis revealed IL-6 (P=0.002, 95%CI=0.006-0.025) and IL-10 (P=0.01 95%CI=0.021-0.150) as independent factors for increased SLEDAI-2K. IL-6, IL-10, and IL-17A are candidate biomarkers for disease activity in cSLE patients. This is the first longitudinal study to support their pivotal role in the pathogenesis of the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19475/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL28380214 2017 sil-cyt.oa.pdf28380214 2017 sil-cyt.oa.pdfapplication/pdf387291https://www.arca.fiocruz.br/bitstream/icict/19475/2/28380214%202017%20sil-cyt.oa.pdf6869268ce08836f0b4372130209c8f91MD52TEXT28380214 2017 sil-cyt.oa.pdf.txt28380214 2017 sil-cyt.oa.pdf.txtExtracted texttext/plain36415https://www.arca.fiocruz.br/bitstream/icict/19475/3/28380214%202017%20sil-cyt.oa.pdf.txt34059ef5d588203b9fa9a43e33a087ebMD53icict/194752019-04-02 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dc.title.pt_BR.fl_str_mv Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
title Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
spellingShingle Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
Cavalcanti, A.
Citocinas
Lúpus eritematoso sistêmico de início na infância
Atividade de doença
SLEDAI-2K
Inflamação
Cytokines
Childhood-onset systemic lupus erythematosus
Disease activity
SLEDAI-2K
Inflammation
Lúpus Eritematoso Sistémico , Sistémico / sangue
Citocinas / sangue
title_short Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
title_full Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
title_fullStr Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
title_full_unstemmed Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
title_sort Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
author Cavalcanti, A.
author_facet Cavalcanti, A.
Santos, R.
Mesquita, Z.
Duarte, A. L. B. P.
Lucena-Silva, N.
author_role author
author2 Santos, R.
Mesquita, Z.
Duarte, A. L. B. P.
Lucena-Silva, N.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cavalcanti, A.
Santos, R.
Mesquita, Z.
Duarte, A. L. B. P.
Lucena-Silva, N.
dc.subject.other.none.fl_str_mv Citocinas
Lúpus eritematoso sistêmico de início na infância
Atividade de doença
SLEDAI-2K
Inflamação
topic Citocinas
Lúpus eritematoso sistêmico de início na infância
Atividade de doença
SLEDAI-2K
Inflamação
Cytokines
Childhood-onset systemic lupus erythematosus
Disease activity
SLEDAI-2K
Inflammation
Lúpus Eritematoso Sistémico , Sistémico / sangue
Citocinas / sangue
dc.subject.en.none.fl_str_mv Cytokines
Childhood-onset systemic lupus erythematosus
Disease activity
SLEDAI-2K
Inflammation
dc.subject.decs.none.fl_str_mv Lúpus Eritematoso Sistémico , Sistémico / sangue
Citocinas / sangue
description Universidade Federal de Pernambuco. Hospital das Clínicas. Unidade de Reumatologia. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-06-21T17:58:17Z
dc.date.available.fl_str_mv 2017-06-21T17:58:17Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAVALCANTI, A. et al. Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study. Brazilian Journal of Medical and Biological Research, v. 50, n. 4, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19475
dc.identifier.issn.pt_BR.fl_str_mv 1414-431X
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/1414-431X20175738
identifier_str_mv CAVALCANTI, A. et al. Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study. Brazilian Journal of Medical and Biological Research, v. 50, n. 4, 2017.
1414-431X
10.1590/1414-431X20175738
url https://www.arca.fiocruz.br/handle/icict/19475
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/19475/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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