Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation

Detalhes bibliográficos
Autor(a) principal: Ferreira, Evanilce
Data de Publicação: 2009
Outros Autores: Mendes, Ygara S., Silva, Jerson L., Galler, Ricardo, Oliveira, Andréa C., Freire, Marcos S., Gaspar, Luciane P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32028
Resumo: Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
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spelling Ferreira, EvanilceMendes, Ygara S.Silva, Jerson L.Galler, RicardoOliveira, Andréa C.Freire, Marcos S.Gaspar, Luciane P.2019-03-11T14:41:43Z2019-03-11T14:41:43Z2009FERREIRA, Evanilce et al. Effects of hydrostatic pressure on the stability and thermostability of poliovirus: A new method for vaccine preservation. Vaccine, Amsterdam, v. 27, n. 9, p. 5332-5337, 2009.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/3202810.1016/j.vaccine.2009.06.0991873-2518engEffects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Programa de Biologia Estrutural. Instituto de Bioquímica Médica e Centro Nacional de Ressonância Magnética Nuclear de Macromoléculas Jiri Jonas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Programa de Biologia Estrutural. Instituto de Bioquímica Médica e Centro Nacional de Ressonância Magnética Nuclear de Macromoléculas Jiri Jonas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Programa de Biologia Estrutural. Instituto de Bioquímica Médica e Centro Nacional de Ressonância Magnética Nuclear de Macromoléculas Jiri Jonas, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Viruses are a structurally diverse group of infectious agents that differ widely in their sensitivities to high hydrostatic pressure (HHP). Studies on picornaviruses have demonstrated that these viruses are extremely resistant to HHP treatments, with poliovirus appearing to be the most resistant. Here, the three attenuated poliovirus serotypes were compared with regard to pressure and thermal resistance. We found that HHP does not inactivate any of the three serotypes studied (1–3). Rather, HHP treatment was found to stabilize poliovirus by increasing viral thermal resistance at 37 °C. Identification of new methods that stabilize poliovirus against heat inactivation would aid in the design of a more heat-stable vaccine, circumventing the problems associated with refrigeration during storage and transport of the vaccine prior to use.PoliovirusHydrostatic pressureVaccine stabilityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32028/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALF90-1-s2.0-S0264410X09009736-main.pdfapplication/pdf543360https://www.arca.fiocruz.br/bitstream/icict/32028/2/F90-1-s2.0-S0264410X09009736-main.pdf46e5a708f50aedd123f781634f7ca772MD52TEXTF90-1-s2.0-S0264410X09009736-main.pdf.txtF90-1-s2.0-S0264410X09009736-main.pdf.txtExtracted texttext/plain28681https://www.arca.fiocruz.br/bitstream/icict/32028/3/F90-1-s2.0-S0264410X09009736-main.pdf.txt19dabde805a10d55240fd7064ec06ef0MD53icict/320282019-04-04 02:05:15.468oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-04T05:05:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
title Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
spellingShingle Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
Ferreira, Evanilce
Poliovirus
Hydrostatic pressure
Vaccine stability
title_short Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
title_full Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
title_fullStr Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
title_full_unstemmed Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
title_sort Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
author Ferreira, Evanilce
author_facet Ferreira, Evanilce
Mendes, Ygara S.
Silva, Jerson L.
Galler, Ricardo
Oliveira, Andréa C.
Freire, Marcos S.
Gaspar, Luciane P.
author_role author
author2 Mendes, Ygara S.
Silva, Jerson L.
Galler, Ricardo
Oliveira, Andréa C.
Freire, Marcos S.
Gaspar, Luciane P.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Evanilce
Mendes, Ygara S.
Silva, Jerson L.
Galler, Ricardo
Oliveira, Andréa C.
Freire, Marcos S.
Gaspar, Luciane P.
dc.subject.en.pt_BR.fl_str_mv Poliovirus
Hydrostatic pressure
Vaccine stability
topic Poliovirus
Hydrostatic pressure
Vaccine stability
description Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-03-11T14:41:43Z
dc.date.available.fl_str_mv 2019-03-11T14:41:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Evanilce et al. Effects of hydrostatic pressure on the stability and thermostability of poliovirus: A new method for vaccine preservation. Vaccine, Amsterdam, v. 27, n. 9, p. 5332-5337, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32028
dc.identifier.issn.pt_BR.fl_str_mv 0264-410X
dc.identifier.doi.none.fl_str_mv 10.1016/j.vaccine.2009.06.099
dc.identifier.eissn.none.fl_str_mv 1873-2518
identifier_str_mv FERREIRA, Evanilce et al. Effects of hydrostatic pressure on the stability and thermostability of poliovirus: A new method for vaccine preservation. Vaccine, Amsterdam, v. 27, n. 9, p. 5332-5337, 2009.
0264-410X
10.1016/j.vaccine.2009.06.099
1873-2518
url https://www.arca.fiocruz.br/handle/icict/32028
dc.language.iso.fl_str_mv eng
language eng
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