A heme-degradation pathway in a blood-sucking insect

Detalhes bibliográficos
Autor(a) principal: Silva, Gabriela O. Palva
Data de Publicação: 2006
Outros Autores: Oliveira, Christine Cruz, Nakayasu, Ernesto S., Maya-Monteiro, Clarissa M., Dunkov, Boris C., Masuda, Hatisaburo, Almeida, Igor C., Oliveira, Pedro L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39586
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
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spelling Silva, Gabriela O. PalvaOliveira, Christine CruzNakayasu, Ernesto S.Maya-Monteiro, Clarissa M.Dunkov, Boris C.Masuda, HatisaburoAlmeida, Igor C.Oliveira, Pedro L.2020-01-29T15:56:42Z2020-01-29T15:56:42Z2006SILVA, Gabriela O. Paiva et al. A heme-degradation pathway in a blood-sucking insect. PNAS, v. 103, n. 21, p. 8030-8035, May 2006.0027-8424https://www.arca.fiocruz.br/handle/icict/3958610.1073/pnas.06022241031091-6490engNational Academy of SciencesRhodniusEstresse oxidativoBiliverdinHeme oxygenaseBiliverdinHeme oxygenaseOxidative stressRhodniusA heme-degradation pathway in a blood-sucking insectinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.University of Texas. Department of Biological Sciences. El Paso, TX, USA / Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.University of Arizona. Center for Insect Science. Department of Biochemistry and Molecular Biophysics. Tucson, AZ, USA.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.University of Texas. Department of Biological Sciences. El Paso, TX, USA / Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil /Hematophagous insects are vectors of diseases that affect hundreds of millions of people worldwide. A common physiological event in the life of these insects is the hydrolysis of host hemoglobin in the digestive tract, leading to a massive release of heme, aknownprooxidantmolecule.Diverseorganisms,frombacteriato plants, express the enzyme heme oxygenase, which catalyzes the oxidative degradation of heme to biliverdin (BV) IX, CO, and iron. Here, we show that the kissing bug Rhodnius prolixus, a vector of Chagas’disease,hasauniqueheme-degradationpathwaywherein heme is first modified by addition of two cysteinylglycine residues beforecleavageoftheporphyrinring,followedbytrimmingofthe dipeptides. Furthermore, in contrast to most known heme oxygenases, which generate BV IX , in this insect, the end product of hemedetoxificationisadicysteinyl-BVIX .Basedontheseresults, we propose a heme metabolizing pathway that includes the identified intermediates produced during modification and cleavage of the heme porphyrin ring.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39586/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClarissaMaya_MOnteiro_etal_IOC_2006.pdfClarissaMaya_MOnteiro_etal_IOC_2006.pdfapplication/pdf1402564https://www.arca.fiocruz.br/bitstream/icict/39586/2/ClarissaMaya_MOnteiro_etal_IOC_2006.pdf73e02ec7d3cfb32b17e7da13811d03a2MD52TEXTClarissaMaya_MOnteiro_etal_IOC_2006.pdf.txtClarissaMaya_MOnteiro_etal_IOC_2006.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv A heme-degradation pathway in a blood-sucking insect
title A heme-degradation pathway in a blood-sucking insect
spellingShingle A heme-degradation pathway in a blood-sucking insect
Silva, Gabriela O. Palva
Rhodnius
Estresse oxidativo
Biliverdin
Heme oxygenase
Biliverdin
Heme oxygenase
Oxidative stress
Rhodnius
title_short A heme-degradation pathway in a blood-sucking insect
title_full A heme-degradation pathway in a blood-sucking insect
title_fullStr A heme-degradation pathway in a blood-sucking insect
title_full_unstemmed A heme-degradation pathway in a blood-sucking insect
title_sort A heme-degradation pathway in a blood-sucking insect
author Silva, Gabriela O. Palva
author_facet Silva, Gabriela O. Palva
Oliveira, Christine Cruz
Nakayasu, Ernesto S.
Maya-Monteiro, Clarissa M.
Dunkov, Boris C.
Masuda, Hatisaburo
Almeida, Igor C.
Oliveira, Pedro L.
author_role author
author2 Oliveira, Christine Cruz
Nakayasu, Ernesto S.
Maya-Monteiro, Clarissa M.
Dunkov, Boris C.
Masuda, Hatisaburo
Almeida, Igor C.
Oliveira, Pedro L.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Gabriela O. Palva
Oliveira, Christine Cruz
Nakayasu, Ernesto S.
Maya-Monteiro, Clarissa M.
Dunkov, Boris C.
Masuda, Hatisaburo
Almeida, Igor C.
Oliveira, Pedro L.
dc.subject.other.pt_BR.fl_str_mv Rhodnius
Estresse oxidativo
Biliverdin
Heme oxygenase
topic Rhodnius
Estresse oxidativo
Biliverdin
Heme oxygenase
Biliverdin
Heme oxygenase
Oxidative stress
Rhodnius
dc.subject.en.pt_BR.fl_str_mv Biliverdin
Heme oxygenase
Oxidative stress
Rhodnius
description Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2020-01-29T15:56:42Z
dc.date.available.fl_str_mv 2020-01-29T15:56:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Gabriela O. Paiva et al. A heme-degradation pathway in a blood-sucking insect. PNAS, v. 103, n. 21, p. 8030-8035, May 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39586
dc.identifier.issn.pt_BR.fl_str_mv 0027-8424
dc.identifier.doi.none.fl_str_mv 10.1073/pnas.0602224103
dc.identifier.eissn.none.fl_str_mv 1091-6490
identifier_str_mv SILVA, Gabriela O. Paiva et al. A heme-degradation pathway in a blood-sucking insect. PNAS, v. 103, n. 21, p. 8030-8035, May 2006.
0027-8424
10.1073/pnas.0602224103
1091-6490
url https://www.arca.fiocruz.br/handle/icict/39586
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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