Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59189 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil. |
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Filgueiras, Priscilla SoaresCorsini, Camila AmorminoAlmeida, Nathalie Bonatti FrancoPedrosa, Maria Luysa CamargosMiranda, Daniel Alvim Pena deGomes, Sarah Vieira ContinAssis, Jéssica Vieira deSilva, Raphael AntônioMedeiros, Maria Izabella Vieira de Assis Rocha Carvalho deLourenço, Adelina JuniaBicalho, Cecilia Maria FlorencioVilela, Raquel Virginia RochaJeremias, Wander de JesusFernandes, Gabriel da RochaQueiroz, Rafaella Fortini Grenfell e2023-06-27T14:09:53Z2023-06-27T14:09:53Z2023FILGUEIRAS, Priscilla Soares et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Rev Soc Bras Med Trop, v. 56, p. e01672022-e01672022, 2023. doi:.org/10.1590/0037-8682-0167-2022.1678-9849https://www.arca.fiocruz.br/handle/icict/59189engSociedade Brasileira De Medicina TropicalRapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade da Geórgia. Faculdade de Medicina Veterinária. Departamento de Doenças Infecciosas. Athens, GA, Estados Unidos da América.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Ouro Preto. Departamento de Farmácia. Ouro Preto, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Informática de Biossistemas. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil/Universidade da Geórgia. Faculdade de Medicina Veterinária. Departamento de Doenças Infecciosas. Athens, GA, Estados Unidos da AméricaBackground: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigendetecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control.COVID-19SARS-CoV-2Rapid testAntigen testSelf-testinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59189/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRapid antigen test as a tool for the identification.pdfRapid antigen test as a tool for the identification.pdfapplication/pdf437960https://www.arca.fiocruz.br/bitstream/icict/59189/2/Rapid%20antigen%20test%20as%20a%20tool%20for%20the%20identification.pdfc47027b3f42893f620ef9f885358333bMD52icict/591892023-06-27 11:09:54.327oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-27T14:09:54Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.en_US.fl_str_mv |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
| title |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
| spellingShingle |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Filgueiras, Priscilla Soares COVID-19 SARS-CoV-2 Rapid test Antigen test Self-test |
| title_short |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
| title_full |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
| title_fullStr |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
| title_full_unstemmed |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
| title_sort |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
| author |
Filgueiras, Priscilla Soares |
| author_facet |
Filgueiras, Priscilla Soares Corsini, Camila Amormino Almeida, Nathalie Bonatti Franco Pedrosa, Maria Luysa Camargos Miranda, Daniel Alvim Pena de Gomes, Sarah Vieira Contin Assis, Jéssica Vieira de Silva, Raphael Antônio Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de Lourenço, Adelina Junia Bicalho, Cecilia Maria Florencio Vilela, Raquel Virginia Rocha Jeremias, Wander de Jesus Fernandes, Gabriel da Rocha Queiroz, Rafaella Fortini Grenfell e |
| author_role |
author |
| author2 |
Corsini, Camila Amormino Almeida, Nathalie Bonatti Franco Pedrosa, Maria Luysa Camargos Miranda, Daniel Alvim Pena de Gomes, Sarah Vieira Contin Assis, Jéssica Vieira de Silva, Raphael Antônio Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de Lourenço, Adelina Junia Bicalho, Cecilia Maria Florencio Vilela, Raquel Virginia Rocha Jeremias, Wander de Jesus Fernandes, Gabriel da Rocha Queiroz, Rafaella Fortini Grenfell e |
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author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Filgueiras, Priscilla Soares Corsini, Camila Amormino Almeida, Nathalie Bonatti Franco Pedrosa, Maria Luysa Camargos Miranda, Daniel Alvim Pena de Gomes, Sarah Vieira Contin Assis, Jéssica Vieira de Silva, Raphael Antônio Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de Lourenço, Adelina Junia Bicalho, Cecilia Maria Florencio Vilela, Raquel Virginia Rocha Jeremias, Wander de Jesus Fernandes, Gabriel da Rocha Queiroz, Rafaella Fortini Grenfell e |
| dc.subject.en.en_US.fl_str_mv |
COVID-19 SARS-CoV-2 Rapid test Antigen test Self-test |
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COVID-19 SARS-CoV-2 Rapid test Antigen test Self-test |
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Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil. |
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2023 |
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2023-06-27T14:09:53Z |
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2023-06-27T14:09:53Z |
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2023 |
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FILGUEIRAS, Priscilla Soares et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Rev Soc Bras Med Trop, v. 56, p. e01672022-e01672022, 2023. doi:.org/10.1590/0037-8682-0167-2022. |
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1678-9849 |
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FILGUEIRAS, Priscilla Soares et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Rev Soc Bras Med Trop, v. 56, p. e01672022-e01672022, 2023. doi:.org/10.1590/0037-8682-0167-2022. 1678-9849 |
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