Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients

Detalhes bibliográficos
Autor(a) principal: Souza, Claudio Lima
Data de Publicação: 2008
Outros Autores: Barbosa, Cynara Gomes, Moura Neto, José Pereira de, Barreto, José Henrique Silva, Reis, Mitermayer Galvão dos, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6179
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
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spelling Souza, Claudio LimaBarbosa, Cynara GomesMoura Neto, José Pereira deBarreto, José Henrique SilvaReis, Mitermayer Galvão dosGonçalves, Marilda de Souza2013-01-14T17:36:55Z2013-01-14T17:36:55Z2008SOUZA, C. L. et al. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics and Molecular Biology, v. 31, n. 1, p. 39-41, 2008.1415-4757https://www.arca.fiocruz.br/handle/icict/6179engPolymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, BrasilUniversidade Federal da Bahia. Clínica Onco. Salvador, Bahia, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilThe null genotype for glutathione S-transferase (GST, EC 2.5.1.18) gene polymorphisms is considered a risk factor for leukemia in different populations. In this work we investigated the GSTT1 and GSTM1 polymorphisms using multiplex PCR in 53 patients with chronic myeloid leukemia (CML), 23 with acute promyelocytic leukemia (APL) and 304 apparently healthy controls. In this association study we found that the GSTT1null genotype was more frequent in our group of APL patients than in the control group [OR = 2.75 (95 percent CI = 1.10-6.88)], providing evidence that a deletion in the GSTT1 gene could be a risk factor for this type of leukemia.Acute promyelocytic leukemiaChronic myeloid leukemiaGSTM1GSTT1Gene polymorphismGlutationa TransferaseLeucemia Promielocítica AgudaLeucemia MielóideFatores de RiscoPolimorfismo GenéticoGenótipoReação em Cadeia da PolimeraseBrasilHumanosMasculinoFemininoAdolescenteAdultoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSouza, Claudia Lima et al. Polymorphisms in the glutathione....pdfSouza, Claudia Lima et al. Polymorphisms in the glutathione....pdfapplication/pdf63581https://www.arca.fiocruz.br/bitstream/icict/6179/1/Souza%2c%20Claudia%20Lima%20et%20al.%20Polymorphisms%20in%20the%20glutathione....pdf8b4b143bdc6e70edba2a50e0e61c10faMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6179/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSouza, Claudia Lima et al. Polymorphisms in the glutathione....pdf.txtSouza, Claudia Lima et al. Polymorphisms in the glutathione....pdf.txtExtracted texttext/plain16124https://www.arca.fiocruz.br/bitstream/icict/6179/5/Souza%2c%20Claudia%20Lima%20et%20al.%20Polymorphisms%20in%20the%20glutathione....pdf.txt4314213476b781778a0c155be8de6e3aMD55THUMBNAILSouza, Claudia Lima et al. Polymorphisms in the glutathione....pdf.jpgSouza, Claudia Lima et al. Polymorphisms in the glutathione....pdf.jpgGenerated Thumbnailimage/jpeg2118https://www.arca.fiocruz.br/bitstream/icict/6179/4/Souza%2c%20Claudia%20Lima%20et%20al.%20Polymorphisms%20in%20the%20glutathione....pdf.jpgf792006696d6ccba66be082abe943b3bMD54icict/61792023-03-15 14:32:57.669oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
title Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
spellingShingle Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
Souza, Claudio Lima
Acute promyelocytic leukemia
Chronic myeloid leukemia
GSTM1
GSTT1
Gene polymorphism
Glutationa Transferase
Leucemia Promielocítica Aguda
Leucemia Mielóide
Fatores de Risco
Polimorfismo Genético
Genótipo
Reação em Cadeia da Polimerase
Brasil
Humanos
Masculino
Feminino
Adolescente
Adulto
title_short Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
title_full Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
title_fullStr Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
title_full_unstemmed Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
title_sort Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
author Souza, Claudio Lima
author_facet Souza, Claudio Lima
Barbosa, Cynara Gomes
Moura Neto, José Pereira de
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author_role author
author2 Barbosa, Cynara Gomes
Moura Neto, José Pereira de
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Claudio Lima
Barbosa, Cynara Gomes
Moura Neto, José Pereira de
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
dc.subject.en.pt_BR.fl_str_mv Acute promyelocytic leukemia
Chronic myeloid leukemia
GSTM1
GSTT1
Gene polymorphism
topic Acute promyelocytic leukemia
Chronic myeloid leukemia
GSTM1
GSTT1
Gene polymorphism
Glutationa Transferase
Leucemia Promielocítica Aguda
Leucemia Mielóide
Fatores de Risco
Polimorfismo Genético
Genótipo
Reação em Cadeia da Polimerase
Brasil
Humanos
Masculino
Feminino
Adolescente
Adulto
dc.subject.decs.pt_BR.fl_str_mv Glutationa Transferase
Leucemia Promielocítica Aguda
Leucemia Mielóide
Fatores de Risco
Polimorfismo Genético
Genótipo
Reação em Cadeia da Polimerase
Brasil
Humanos
Masculino
Feminino
Adolescente
Adulto
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-01-14T17:36:55Z
dc.date.available.fl_str_mv 2013-01-14T17:36:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, C. L. et al. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics and Molecular Biology, v. 31, n. 1, p. 39-41, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6179
dc.identifier.issn.none.fl_str_mv 1415-4757
identifier_str_mv SOUZA, C. L. et al. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics and Molecular Biology, v. 31, n. 1, p. 39-41, 2008.
1415-4757
url https://www.arca.fiocruz.br/handle/icict/6179
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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