Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes

Detalhes bibliográficos
Autor(a) principal: Marinho, Fernanda de Aquino
Data de Publicação: 2011
Outros Autores: Gonçalves, Keyla Cristiny da Silva, Oliveira, Selma Soares de, Oliveira, Ana Carolina de Siqueira Couto de, Bellio, Maria, Levy, Claudia Masini d'Avila, Santos, André Luis Souza dos, Branquinha, Marta Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16228
Resumo: Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.
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spelling Marinho, Fernanda de AquinoGonçalves, Keyla Cristiny da SilvaOliveira, Selma Soares deOliveira, Ana Carolina de Siqueira Couto deBellio, MariaLevy, Claudia Masini d'AvilaSantos, André Luis Souza dosBranquinha, Marta Helena2016-10-13T17:24:18Z2016-10-13T17:24:18Z2011MARINHO, Fernanda de Aquino; et al. Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes. Mem Inst Oswaldo Cruz, v.106, n.4, p.507-509, June 2011.0074-0276https://www.arca.fiocruz.br/handle/icict/162281678-8060engFundação Oswaldo CruzLeishmanioseQuimioterapiaApoptoseleishmaniasischemotherapyapoptosisMiltefosine induces programmed cell death in Leishmania amazonensis promastigotesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis promastigotes. Miltefosine induced a process of programmed cell death, which was determined by the externalization of phosphatidylserine, the incorporation of propidium iodide, cell-cycle arrest at the sub-G0 /G1 phase and DNA fragmentation into oligonucleosome-sized fragments. Despite the intrinsic variation that is detected in Leishmania spp, our results indicate that miltefosine causes apoptosislike death in L. amazonensis promastigote cells using a similar process that is observed in Leishmania donovani.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16228/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALclaudia2_levy_etal_IOC_2011.pdfclaudia2_levy_etal_IOC_2011.pdfapplication/pdf354294https://www.arca.fiocruz.br/bitstream/icict/16228/2/claudia2_levy_etal_IOC_2011.pdf30afc282166c4248d93e608c436a2d15MD52TEXTclaudia2_levy_etal_IOC_2011.pdf.txtclaudia2_levy_etal_IOC_2011.pdf.txtExtracted texttext/plain14508https://www.arca.fiocruz.br/bitstream/icict/16228/3/claudia2_levy_etal_IOC_2011.pdf.txt6bbdc55143752ee3773deddcb524f96aMD53icict/162282022-06-24 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dc.title.pt_BR.fl_str_mv Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
title Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
spellingShingle Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
Marinho, Fernanda de Aquino
Leishmaniose
Quimioterapia
Apoptose
leishmaniasis
chemotherapy
apoptosis
title_short Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
title_full Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
title_fullStr Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
title_full_unstemmed Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
title_sort Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
author Marinho, Fernanda de Aquino
author_facet Marinho, Fernanda de Aquino
Gonçalves, Keyla Cristiny da Silva
Oliveira, Selma Soares de
Oliveira, Ana Carolina de Siqueira Couto de
Bellio, Maria
Levy, Claudia Masini d'Avila
Santos, André Luis Souza dos
Branquinha, Marta Helena
author_role author
author2 Gonçalves, Keyla Cristiny da Silva
Oliveira, Selma Soares de
Oliveira, Ana Carolina de Siqueira Couto de
Bellio, Maria
Levy, Claudia Masini d'Avila
Santos, André Luis Souza dos
Branquinha, Marta Helena
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marinho, Fernanda de Aquino
Gonçalves, Keyla Cristiny da Silva
Oliveira, Selma Soares de
Oliveira, Ana Carolina de Siqueira Couto de
Bellio, Maria
Levy, Claudia Masini d'Avila
Santos, André Luis Souza dos
Branquinha, Marta Helena
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Quimioterapia
Apoptose
topic Leishmaniose
Quimioterapia
Apoptose
leishmaniasis
chemotherapy
apoptosis
dc.subject.en.pt_BR.fl_str_mv leishmaniasis
chemotherapy
apoptosis
description Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2016-10-13T17:24:18Z
dc.date.available.fl_str_mv 2016-10-13T17:24:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARINHO, Fernanda de Aquino; et al. Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes. Mem Inst Oswaldo Cruz, v.106, n.4, p.507-509, June 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16228
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MARINHO, Fernanda de Aquino; et al. Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes. Mem Inst Oswaldo Cruz, v.106, n.4, p.507-509, June 2011.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/16228
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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