An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57495 |
Resumo: | Laboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil |
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Gonçalves, Ana Alice MaiaLeite, Jaqueline CostaResende, Lucilene AparecidaMariano, Reysla Maria da SilveiraSilveira, PatriciaMelo-Júnior, Otoni Alves de OliveiraRibeiro, Helen SilvaOliveira, Diana Souza deSoares, Diogo FonsecaSantos, Thaiza Aline PereiraMarques, Alexandre FerreiraGaldino, Alexsandro SobreiraMartins Filho, Olindo AssisDutra, Walderez OrnelasSilveira-Lemos, Denise daGiunchetti, Rodolfo Cordeiro2023-03-21T19:29:45Z2023-03-21T19:29:45Z2019GONÇALVES, Ana Alice Maia et al. An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy. Front. Cell. Infect. Microbiol., v. 9, 427, 2019. doi.org/10.3389/fcimb.2019.004272235-2988https://www.arca.fiocruz.br/handle/icict/57495engFrontiers Media SAAn Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Immuno-Proteome and Parasite Biology. Department of Parasitology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biotechnology of Microorganisms. Federal University of São João Del-Rei. Divinópolis, MG, BrazilLaboratory of Diagnostic and Monitoring Biomarkers. René Rachou Institute. Oswaldo , Belo Horizonte, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilVisceral leishmaniasis (VL), caused by digenetic protozoa of the genus Leishmania, is the most severe form of leishmaniasis. Leishmania infantum is one of the species responsible for VL and the disease caused is considered a zoonosis whose main reservoir is the dog. Canine visceral leishmaniasis (CVL) can lead to the death of the animal if left untreated. Furthermore, the available pharmocologial treatment for CVL presents numerous disadvantages, such as relapses, toxicity, drug resistance, and the fact treated animals continue to be reservoirs when treatment fails to achieve parasitological cure. Moreover, the available VL control methods have not been adequate when it comes to controlling parasite transmission. Advances in immune response knowledge in recent years have led to a better understanding of VL pathogenesis, allowing new treatments to be developed based on immune system activation, often referred to as immunotherapy. In fact, well-defined protocols have been described, ranging from the use of immunomodulators to the use of vaccines. This treatment, which can also be associated with chemotherapy, has been shown to be effective in restoring or inducing an adequate immune response to reduce parasitic burden, leading to clinical improvement. This review focuses on immunotherapy directed at dogs infected by L. infantum, including a literature review of what has already been done in dogs. We also introduce a promising strategy to improve the efficacy of immunotherapy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57495/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAn Overview of Immunotherapeutic Approaches Against.pdfAn Overview of Immunotherapeutic Approaches Against.pdfapplication/pdf672116https://www.arca.fiocruz.br/bitstream/icict/57495/2/An%20Overview%20of%20Immunotherapeutic%20Approaches%20Against.pdf7d56afdd7f6f501c4f47d6f9e80f375eMD52icict/574952023-03-21 16:29:46.533oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-21T19:29:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy |
| title |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy |
| spellingShingle |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy Gonçalves, Ana Alice Maia |
| title_short |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy |
| title_full |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy |
| title_fullStr |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy |
| title_full_unstemmed |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy |
| title_sort |
An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy |
| author |
Gonçalves, Ana Alice Maia |
| author_facet |
Gonçalves, Ana Alice Maia Leite, Jaqueline Costa Resende, Lucilene Aparecida Mariano, Reysla Maria da Silveira Silveira, Patricia Melo-Júnior, Otoni Alves de Oliveira Ribeiro, Helen Silva Oliveira, Diana Souza de Soares, Diogo Fonseca Santos, Thaiza Aline Pereira Marques, Alexandre Ferreira Galdino, Alexsandro Sobreira Martins Filho, Olindo Assis Dutra, Walderez Ornelas Silveira-Lemos, Denise da Giunchetti, Rodolfo Cordeiro |
| author_role |
author |
| author2 |
Leite, Jaqueline Costa Resende, Lucilene Aparecida Mariano, Reysla Maria da Silveira Silveira, Patricia Melo-Júnior, Otoni Alves de Oliveira Ribeiro, Helen Silva Oliveira, Diana Souza de Soares, Diogo Fonseca Santos, Thaiza Aline Pereira Marques, Alexandre Ferreira Galdino, Alexsandro Sobreira Martins Filho, Olindo Assis Dutra, Walderez Ornelas Silveira-Lemos, Denise da Giunchetti, Rodolfo Cordeiro |
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author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gonçalves, Ana Alice Maia Leite, Jaqueline Costa Resende, Lucilene Aparecida Mariano, Reysla Maria da Silveira Silveira, Patricia Melo-Júnior, Otoni Alves de Oliveira Ribeiro, Helen Silva Oliveira, Diana Souza de Soares, Diogo Fonseca Santos, Thaiza Aline Pereira Marques, Alexandre Ferreira Galdino, Alexsandro Sobreira Martins Filho, Olindo Assis Dutra, Walderez Ornelas Silveira-Lemos, Denise da Giunchetti, Rodolfo Cordeiro |
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Laboratory of Biology of Cell Interactions. Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil |
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2019 |
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2019 |
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2023-03-21T19:29:45Z |
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2023-03-21T19:29:45Z |
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GONÇALVES, Ana Alice Maia et al. An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy. Front. Cell. Infect. Microbiol., v. 9, 427, 2019. doi.org/10.3389/fcimb.2019.00427 |
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https://www.arca.fiocruz.br/handle/icict/57495 |
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2235-2988 |
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GONÇALVES, Ana Alice Maia et al. An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy. Front. Cell. Infect. Microbiol., v. 9, 427, 2019. doi.org/10.3389/fcimb.2019.00427 2235-2988 |
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