Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/53592 |
Resumo: | Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. |
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Araújo, Bruno Espírito Santo deFontana, Rosiane da SilvaBarbosa, Maria Clara de MagalhãesSetta, Fernanda LimaParavidino, Vitor BarretoRiveiro, Paula MarinsPulcheri, Lucas BerbertSalú, Margarida dos SantosOliveira, Mariana Barros GenuínoRobaína, Jaqueline RodriguesCunha, Antonio José Ledo Alves daCruz, Fernanda FerreiraRocco, Patricia Rieken MacedoBozza, Fernando AugustoFaria Neto, Hugo Caire de CastroBarbosa, Arnaldo Prata2022-06-30T14:38:40Z2022-06-30T14:38:40Z2022ARAÚJO, Bruno Espírito Santo de et al. Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy. Scientifc Reports, v. 12, 10673, p. 1 - 12, 2022.2045-2322https://www.arca.fiocruz.br/handle/icict/5359210.1038/s41598-022-14853-zengNature PortfolioCaracterísticas clínicasEletroencefalogramaBiomarcadoresPediatriaEncefalopatiaAssociada à sepseClinical featuresElectroencephalogramBiomarkersPediatricEncephalopathySepsis‑associatedClinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer (IECPN). Departamento de Neurologia. Rio de Janeiro, RJ, Brasil.Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil / Marinha do Brasil. Academia Naval. Departamento de Educação Física e Desportos. Rio de Janeiro, RJ, BrasilHospital Caxias D`OR. Unidade de Terapia Intensiva Pediátrica. Duque de Caxias, RJ, Brasil.Hospital Rios D`Or. Unidade de Terapia Intensiva Pediátrica. Rio de Janeiro, RJ, Brasil.Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. Rede do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. Rede do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Instituto D´OR de Pesquisa e Educação. Departamento de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro, RJ, Brasil.To date, no specific diagnostic criteria for sepsis-associated encephalopathy (SAE) have been established. We studied 33 pediatric patients with sepsis prospectively and evaluated the level of consciousness, the presence of delirium, electroencephalographic (EEG) findings, and plasma levels of neuron-specific enolase and S100-calcium-binding protein-B. A presumptive diagnosis of SAE was primarily considered in the presence of a decreased level of consciousness and/or delirium (clinical criteria), but specific EEG abnormalities were also considered (EEG criteria). The time course of the biomarkers was compared between groups with and without clinical or EEG criteria. The Functional Status Scale (FSS) was assessed at admission, discharge, and 3–6 months post-discharge. Clinical criteria were identified in 75.8% of patients, EEG criteria in 26.9%, both in 23.1%, and none in 23.1%. Biomarkers did not differ between groups. Three patients had an abnormal FSS at discharge, but no one on follow-up. A definitive diagnostic pattern for SAE remained unclear. Clinical criteria should be the basis for diagnosis, but sedation may be a significant confounder, also affecting EEG interpretation. The role of biomarkers requires a better definition. The diagnosis of SAE in pediatric patients remains a major challenge. New consensual diagnostic definitions and mainly prognostic studies are needed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/53592/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHugoFariaNeto_FernandoBozza_etal_IOC_2022.pdfHugoFariaNeto_FernandoBozza_etal_IOC_2022.pdfapplication/pdf3349890https://www.arca.fiocruz.br/bitstream/icict/53592/2/HugoFariaNeto_FernandoBozza_etal_IOC_2022.pdfcd1218f79775d21a681d190f8591c1bbMD52icict/535922022-06-30 11:38:40.233oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-30T14:38:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy |
title |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy |
spellingShingle |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy Araújo, Bruno Espírito Santo de Características clínicas Eletroencefalograma Biomarcadores Pediatria Encefalopatia Associada à sepse Clinical features Electroencephalogram Biomarkers Pediatric Encephalopathy Sepsis‑associated |
title_short |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy |
title_full |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy |
title_fullStr |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy |
title_full_unstemmed |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy |
title_sort |
Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy |
author |
Araújo, Bruno Espírito Santo de |
author_facet |
Araújo, Bruno Espírito Santo de Fontana, Rosiane da Silva Barbosa, Maria Clara de Magalhães Setta, Fernanda Lima Paravidino, Vitor Barreto Riveiro, Paula Marins Pulcheri, Lucas Berbert Salú, Margarida dos Santos Oliveira, Mariana Barros Genuíno Robaína, Jaqueline Rodrigues Cunha, Antonio José Ledo Alves da Cruz, Fernanda Ferreira Rocco, Patricia Rieken Macedo Bozza, Fernando Augusto Faria Neto, Hugo Caire de Castro Barbosa, Arnaldo Prata |
author_role |
author |
author2 |
Fontana, Rosiane da Silva Barbosa, Maria Clara de Magalhães Setta, Fernanda Lima Paravidino, Vitor Barreto Riveiro, Paula Marins Pulcheri, Lucas Berbert Salú, Margarida dos Santos Oliveira, Mariana Barros Genuíno Robaína, Jaqueline Rodrigues Cunha, Antonio José Ledo Alves da Cruz, Fernanda Ferreira Rocco, Patricia Rieken Macedo Bozza, Fernando Augusto Faria Neto, Hugo Caire de Castro Barbosa, Arnaldo Prata |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Araújo, Bruno Espírito Santo de Fontana, Rosiane da Silva Barbosa, Maria Clara de Magalhães Setta, Fernanda Lima Paravidino, Vitor Barreto Riveiro, Paula Marins Pulcheri, Lucas Berbert Salú, Margarida dos Santos Oliveira, Mariana Barros Genuíno Robaína, Jaqueline Rodrigues Cunha, Antonio José Ledo Alves da Cruz, Fernanda Ferreira Rocco, Patricia Rieken Macedo Bozza, Fernando Augusto Faria Neto, Hugo Caire de Castro Barbosa, Arnaldo Prata |
dc.subject.other.pt_BR.fl_str_mv |
Características clínicas Eletroencefalograma Biomarcadores Pediatria Encefalopatia Associada à sepse |
topic |
Características clínicas Eletroencefalograma Biomarcadores Pediatria Encefalopatia Associada à sepse Clinical features Electroencephalogram Biomarkers Pediatric Encephalopathy Sepsis‑associated |
dc.subject.en.pt_BR.fl_str_mv |
Clinical features Electroencephalogram Biomarkers Pediatric Encephalopathy Sepsis‑associated |
description |
Instituto D´OR de Pesquisa e Educação. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-06-30T14:38:40Z |
dc.date.available.fl_str_mv |
2022-06-30T14:38:40Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ARAÚJO, Bruno Espírito Santo de et al. Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy. Scientifc Reports, v. 12, 10673, p. 1 - 12, 2022. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/53592 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-022-14853-z |
identifier_str_mv |
ARAÚJO, Bruno Espírito Santo de et al. Clinical features, electroencephalogram, and biomarkers in pediatric sepsis‑associated encephalopathy. Scientifc Reports, v. 12, 10673, p. 1 - 12, 2022. 2045-2322 10.1038/s41598-022-14853-z |
url |
https://www.arca.fiocruz.br/handle/icict/53592 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Nature Portfolio |
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Nature Portfolio |
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