Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil

Detalhes bibliográficos
Autor(a) principal: Trilles, Luciana
Data de Publicação: 2008
Outros Autores: Lazéra, Márcia dos Santos, Wanke, Bodo, Oliveira, Raquel Vasconcelos, Barbosa, Gláucia Gonçalves, Nishikawa, Marília Martins, Penarrieta Morales, Bernardina, Meyer, Wieland
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57960
Resumo: CAPES, NH&MRC (ID 990738; ID 352303).
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spelling Trilles, LucianaLazéra, Márcia dos SantosWanke, BodoOliveira, Raquel VasconcelosBarbosa, Gláucia GonçalvesNishikawa, Marília MartinsPenarrieta Morales, BernardinaMeyer, Wieland2023-04-25T00:11:57Z2023-04-25T00:11:57Z2008TRILLES, Luciana et al. Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 455-462, Aug. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/57960CAPES, NH&MRC (ID 990738; ID 352303).Fundação Oswaldo Cruz. Instituto de Pesquisa Cínica Evandro Chagas. Centro de Estatística e Documentação. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Cínica Evandro Chagas. Centro de Estatística e Documentação. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Cínica Evandro Chagas. Centro de Estatística e Documentação. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Cínica Evandro Chagas. Centro de Estatística e Documentação. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Cínica Evandro Chagas. Centro de Estatística e Documentação. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Cínica Evandro Chagas. Centro de Estatística e Documentação. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Cínica Evandro Chagas. Centro de Estatística e Documentação. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.The molecular types of 443 Brazilian isolates of Cryptococcus neoformans and Cryptococcus gattii were analyzed to determine their geographic distribution within Brazil and their underlying host conditions. The following data, imported from previous epidemiological studies as well as two culture collections, were analyzed for: place of isolation, source (clinical or environmental), host risk factors, species, serotype, mating type, and molecular type. Molecular typing by PCR-fingerprinting using primers for the minisatellite-specific core sequence of the wild-type phage M13 or microsatellites [(GACA)4 , (GTG)5 ], restriction fragment length polymorphism of URA5 gene analysis, and/or amplified fragment length polymorphism (AFLP) identified eight major genotypes: VNI/AFLP1, VNII/AFLP1A, VNIII/AFLP2, and VNIV/AFLP3 for C. geoformans, and VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/ AFLP7 for C. gattii. The most common molecular type found in Brazil was VNI (64%), followed by VGII (21%), VNII (5%), VGIII (4%), VGI and VNIV (3% each), and VNIII (< 1%). Primary cryptococcosis caused by the molecular type VGII (serotype B, MATα) prevails in immunocompetent hosts in the North and Northeast regions, disclosing an endemic regional pattern for this specific molecular type in the Northern Brazil.engFiocruz/IOCRegional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCryptococcus neoformansCryptococcus gattiiMolecular typesEpidemiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Luciana_Trilles_etal_INI_INCQS_2008.pdfve_Luciana_Trilles_etal_INI_INCQS_2008.pdfapplication/pdf1033944https://www.arca.fiocruz.br/bitstream/icict/57960/2/ve_Luciana_Trilles_etal_INI_INCQS_2008.pdfecc5ef5eb7ced540bd5fe09f7543cb44MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57960/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/579602023-04-24 21:12:00.446oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-25T00:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
title Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
spellingShingle Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
Trilles, Luciana
Cryptococcus neoformans
Cryptococcus gattii
Molecular types
Epidemiology
title_short Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
title_full Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
title_fullStr Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
title_full_unstemmed Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
title_sort Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
author Trilles, Luciana
author_facet Trilles, Luciana
Lazéra, Márcia dos Santos
Wanke, Bodo
Oliveira, Raquel Vasconcelos
Barbosa, Gláucia Gonçalves
Nishikawa, Marília Martins
Penarrieta Morales, Bernardina
Meyer, Wieland
author_role author
author2 Lazéra, Márcia dos Santos
Wanke, Bodo
Oliveira, Raquel Vasconcelos
Barbosa, Gláucia Gonçalves
Nishikawa, Marília Martins
Penarrieta Morales, Bernardina
Meyer, Wieland
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Trilles, Luciana
Lazéra, Márcia dos Santos
Wanke, Bodo
Oliveira, Raquel Vasconcelos
Barbosa, Gláucia Gonçalves
Nishikawa, Marília Martins
Penarrieta Morales, Bernardina
Meyer, Wieland
dc.subject.en.en_US.fl_str_mv Cryptococcus neoformans
Cryptococcus gattii
Molecular types
Epidemiology
topic Cryptococcus neoformans
Cryptococcus gattii
Molecular types
Epidemiology
description CAPES, NH&MRC (ID 990738; ID 352303).
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2023-04-25T00:11:57Z
dc.date.available.fl_str_mv 2023-04-25T00:11:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TRILLES, Luciana et al. Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 455-462, Aug. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57960
dc.identifier.issn.en_US.fl_str_mv 0074-0276
identifier_str_mv TRILLES, Luciana et al. Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 455-462, Aug. 2008.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/57960
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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