Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

Detalhes bibliográficos
Autor(a) principal: Sá, Nathalia Beatriz Ramos de
Data de Publicação: 2020
Outros Autores: Ribeiro-Alves, Marcelo, Silva, Tatiana Pereira da, Pilotto, Jose Henrique, Rolla, Valeria Cavalcanti, Giacoia-Gripp, Carmem B. W., Scott-Algara, Daniel, Morgado, Mariza Gonçalves, Teixeira, Sylvia Lopes Maia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39792
Resumo: 2020-06-22
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spelling Sá, Nathalia Beatriz Ramos deRibeiro-Alves, MarceloSilva, Tatiana Pereira daPilotto, Jose HenriqueRolla, Valeria CavalcantiGiacoia-Gripp, Carmem B. W.Scott-Algara, DanielMorgado, Mariza GonçalvesTeixeira, Sylvia Lopes Maia2020-02-06T18:07:55Z2020-02-06T18:07:55Z2020SÁ, Nathalia Beatriz Ramos de et al. Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes. BMC Infectious Diseases, v. 20, n. 1, p. 1-12, 2020.1471-2334https://www.arca.fiocruz.br/handle/icict/3979210.1186/s12879-020-4786-5engBMCClinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-06-22Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasi / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Unité de Biologie Cellulaire des Lymphocytes, Institut Pasteur, Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Tuberculosis (TB) and AIDS are the leading causes of infectious disease death worldwide. In some TBHIV co-infected individuals treated for both diseases simultaneously, a pathological inflammatory reaction termed immune reconstitution inflammatory syndrome (IRIS) may occur. The risk factors for IRIS are not fully defined. We investigated the association of HLA-B, HLA-C, and KIR genotypes with TB, HIV-1 infection, and IRIS onset. Methods: Patients were divided into four groups: Group 1-TB+/HIV+ (n = 88; 11 of them with IRIS), Group 2- HIV+(n = 24), Group 3- TB+ (n = 24) and Group 4- healthy volunteers (n = 26). Patients were followed up at INI/FIOCRUZ and HGNI (Rio de Janeiro/Brazil) from 2006 to 2016. The HLA-B and HLA-C loci were typed using SBT, NGS, and KIR genes by PCR-SSP. Unconditional logistic regression models were performed for Protection/risk estimation. Results: Among the individuals with TB as the outcome, KIR2DS2 was associated with increased risk for TB onset (aOR = 2.39, P = 0.04), whereas HLA-B*08 and female gender were associated with protection against TB onset (aOR = 0.23, P = 0.03, and aOR = 0.33, P = 0.01, respectively). Not carrying KIR2DL3 (aOR = 0.18, P = 0.03) and carrying HLA-C*07 (aOR = 0.32, P = 0.04) were associated with protection against TB onset among HIV-infected patients. An increased risk for IRIS onset was associated with having a CD8 count ≤500 cells/mm3 (aOR = 18.23, P = 0.016); carrying the KIR2DS2 gene (aOR = 27.22, P = 0.032), the HLA-B*41 allele (aOR = 68.84, P = 0.033), the KIR2DS1 + HLAC2 pair (aOR = 28.58, P = 0.024); and not carrying the KIR2DL3 + HLA-C1/C2 pair (aOR = 43.04, P = 0.034), and the KIR2DL1 + HLA-C1/C2 pair (aOR = 43.04, P = 0.034). Conclusions: These results suggest the participation of these genes in the immunopathogenic mechanisms related to the conditions studied. This is the first study demonstrating an association of HLA-B*41, KIR2DS2, and KIR + HLAC pairs with IRIS onset among TB-HIV co-infected individuals.HIV-1HLA-B genesHLA-C genesImmune Reconstitution Inflammatory SyndromeKIR genesTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/39792/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALClinical and genetic markers_Marcelo_Ribeiro-Alves_INI_LapClin-AIDS_2020.pdfClinical and genetic markers_Marcelo_Ribeiro-Alves_INI_LapClin-AIDS_2020.pdfapplication/pdf688477https://www.arca.fiocruz.br/bitstream/icict/39792/2/Clinical%20and%20genetic%20markers_Marcelo_Ribeiro-Alves_INI_LapClin-AIDS_2020.pdf39026e3e57380c22d25ffe9ff762becbMD52TEXTClinical and genetic markers_Marcelo_Ribeiro-Alves_INI_LapClin-AIDS_2020.pdf.txtClinical and genetic 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dc.title.pt_BR.fl_str_mv Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
spellingShingle Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
Sá, Nathalia Beatriz Ramos de
HIV-1
HLA-B genes
HLA-C genes
Immune Reconstitution Inflammatory Syndrome
KIR genes
Tuberculosis
title_short Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_full Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_fullStr Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_full_unstemmed Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_sort Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
author Sá, Nathalia Beatriz Ramos de
author_facet Sá, Nathalia Beatriz Ramos de
Ribeiro-Alves, Marcelo
Silva, Tatiana Pereira da
Pilotto, Jose Henrique
Rolla, Valeria Cavalcanti
Giacoia-Gripp, Carmem B. W.
Scott-Algara, Daniel
Morgado, Mariza Gonçalves
Teixeira, Sylvia Lopes Maia
author_role author
author2 Ribeiro-Alves, Marcelo
Silva, Tatiana Pereira da
Pilotto, Jose Henrique
Rolla, Valeria Cavalcanti
Giacoia-Gripp, Carmem B. W.
Scott-Algara, Daniel
Morgado, Mariza Gonçalves
Teixeira, Sylvia Lopes Maia
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sá, Nathalia Beatriz Ramos de
Ribeiro-Alves, Marcelo
Silva, Tatiana Pereira da
Pilotto, Jose Henrique
Rolla, Valeria Cavalcanti
Giacoia-Gripp, Carmem B. W.
Scott-Algara, Daniel
Morgado, Mariza Gonçalves
Teixeira, Sylvia Lopes Maia
dc.subject.en.pt_BR.fl_str_mv HIV-1
HLA-B genes
HLA-C genes
Immune Reconstitution Inflammatory Syndrome
KIR genes
Tuberculosis
topic HIV-1
HLA-B genes
HLA-C genes
Immune Reconstitution Inflammatory Syndrome
KIR genes
Tuberculosis
description 2020-06-22
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-02-06T18:07:55Z
dc.date.available.fl_str_mv 2020-02-06T18:07:55Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SÁ, Nathalia Beatriz Ramos de et al. Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes. BMC Infectious Diseases, v. 20, n. 1, p. 1-12, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39792
dc.identifier.issn.pt_BR.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/s12879-020-4786-5
identifier_str_mv SÁ, Nathalia Beatriz Ramos de et al. Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes. BMC Infectious Diseases, v. 20, n. 1, p. 1-12, 2020.
1471-2334
10.1186/s12879-020-4786-5
url https://www.arca.fiocruz.br/handle/icict/39792
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/39792/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/39792/2/Clinical%20and%20genetic%20markers_Marcelo_Ribeiro-Alves_INI_LapClin-AIDS_2020.pdf
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