Hyperplasia of elastic tissue in hepatic schistosomal fibrosis

Bibliographic Details
Main Author: Andrade, Zilton de Araújo
Publication Date: 1991
Other Authors: Freitas, Luiz Antonio Rodrigues de
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/5710
Summary: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoFreitas, Luiz Antonio Rodrigues de2012-10-22T19:46:01Z2012-10-22T19:46:01Z1991ANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991.0074-0276https://www.arca.fiocruz.br/handle/icict/5710engHyperplasia of elastic tissue in hepatic schistosomal fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilElastic tissue hyperplasia, revealed by means of histological, immunocytochemical and ultra-structural methods, appeared as a prominent change in surgical liver biopsies taken from 61 patients with schistosomal periportal and septal fibrosis. Such hyperplasia was absent in experimental murine schistosomiasis, including mice with "pipe-stem" fibrosis. Displaced connective tissue cells in periportal areas, such as smooth muscle cells, more frequently observed in human material, could be the site of excessive elastin synthesis, and could explain the differences observed in human and experimental materials. Elastic tissue, sometimes represented by its microfibrillar components, also appeared to be more condensed in areas of matrix (collagen) degradation, suggesting a participation of this tissue in the remodelling of the extracellular matrix. By its rectratile properties elastic tissue hyperplasia in hepatic schistosomiasis can cause vascular narrowing and thus play a role in the pathogenesis of portal hypertension.Elastic tissueElastinSchistosomiasisPeriportal fibrosisLiverTecido Elástico/patologiaCirrose Hepática/patologiaHepatopatias Parasitárias/patologiaEsquistossomose mansoni/patologiaAdolescenteAdultoFemininoHumanosHiperplasia/patologiaFígado/ultraestruturaMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Hyperplasia of elastic tissue ....pdfAndrade ZA Hyperplasia of elastic tissue ....pdfapplication/pdf836289https://www.arca.fiocruz.br/bitstream/icict/5710/1/Andrade%20ZA%20Hyperplasia%20of%20elastic%20tissue%20....pdfb8a763239dd7676ebe033d7a51d75b9fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5710/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Hyperplasia of elastic tissue ....pdf.txtAndrade ZA Hyperplasia of elastic tissue ....pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/5710/5/Andrade%20ZA%20Hyperplasia%20of%20elastic%20tissue%20....pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD55THUMBNAILAndrade ZA Hyperplasia of elastic tissue ....pdf.jpgAndrade ZA Hyperplasia of elastic tissue ....pdf.jpgGenerated Thumbnailimage/jpeg2289https://www.arca.fiocruz.br/bitstream/icict/5710/4/Andrade%20ZA%20Hyperplasia%20of%20elastic%20tissue%20....pdf.jpge568b4d2eaa1fea375989d3fa5a4629dMD54icict/57102023-03-15 14:33:15.137oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
title Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
spellingShingle Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
Andrade, Zilton de Araújo
Elastic tissue
Elastin
Schistosomiasis
Periportal fibrosis
Liver
Tecido Elástico/patologia
Cirrose Hepática/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Feminino
Humanos
Hiperplasia/patologia
Fígado/ultraestrutura
Masculino
Meia-Idade
title_short Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
title_full Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
title_fullStr Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
title_full_unstemmed Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
title_sort Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Freitas, Luiz Antonio Rodrigues de
author_role author
author2 Freitas, Luiz Antonio Rodrigues de
author2_role author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Freitas, Luiz Antonio Rodrigues de
dc.subject.en.pt_BR.fl_str_mv Elastic tissue
Elastin
Schistosomiasis
Periportal fibrosis
Liver
topic Elastic tissue
Elastin
Schistosomiasis
Periportal fibrosis
Liver
Tecido Elástico/patologia
Cirrose Hepática/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Feminino
Humanos
Hiperplasia/patologia
Fígado/ultraestrutura
Masculino
Meia-Idade
dc.subject.decs.pt_BR.fl_str_mv Tecido Elástico/patologia
Cirrose Hepática/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Feminino
Humanos
Hiperplasia/patologia
Fígado/ultraestrutura
Masculino
Meia-Idade
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1991
dc.date.issued.fl_str_mv 1991
dc.date.accessioned.fl_str_mv 2012-10-22T19:46:01Z
dc.date.available.fl_str_mv 2012-10-22T19:46:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5710
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv ANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5710
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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