Cardiovascular disease among people living with HIV in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41235 |
Resumo: | 2022-12-31 |
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Boettiger, David C.Escuder, Maria MercedesLaw, Matthew G.Veloso, Valdiléa G.Souza, Rosa A.Ikeda, Maria L. R.Alencastro, Paulo R.Tupinambás, UnaiBrites, CarlosGrinsztejn, BeatrizGgomes, Jackeline O.Ribeiro, SayonaraMcGowan, Catherine C.Jayathilake, KaruCastilho, Jessica L.Grangeiro, Alexandre2020-05-13T23:00:11Z2020-05-13T23:00:11Z2020BOETTIGER, David C. et al. Cardiovascular disease among people living with HIV in Brazil. Tropical Medicine and International Health, p. 1-22, 2020.1360-2276https://www.arca.fiocruz.br/handle/icict/4123510.1111/tmi.13405engWileyhttps://www.arca.fiocruz.br/handle/icict/42422Cardiovascular disease among people living with HIV in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2022-12-31University of California. Institute for Health Policy Studies. San Francisco, CA, USA / University of New South Wales. Kirby Institute. Sydney, Australia.Secretaria de Saúde do Estado de São Paulo. Instituto de Saúde. São Paulo, SP, Brasil.University of New South Wales. Kirby Institute. Sydney, Australia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Secretaria de Saúde do Estado de São Paulo. Centro de Referência e Treinamento em Aids. São Paulo, SP, Brasil.Universidade do Vale do Rio dos Sinos. Faculdade de Saúde. Porto Alegre, RS, Brasil.Departamento de Saúde do Rio Grande do Sul. Clínica de Cuidados e Tratamento do Hospital Sanatório Partenon. Porto Alegre, RS, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.Universidade Federal da Bahia. Complexo Hospitalar da Universidade Edgar Santos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Secretaria de Saúde do Estado de São Paulo. Instituto de Saúde. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Vanderbilt University Medical Center. Division of Infectious Diseases. Nashville, TN, USA.Vanderbilt University Medical Center. Division of Infectious Diseases. Nashville, TN, USA.Vanderbilt University Medical Center. Division of Infectious Diseases. Nashville, TN, USA.Vanderbilt University Medical Center. Division of Infectious Diseases. Nashville, TN, USA.Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Preventiva. São Paulo, SP, Brasil.There is a paucity of data on cardiovascular disease (CVD) among people living with HIV (PLHIV) in resource-limited countries. We assessed factors associated with CVD and the impact of prevalent CVD on all-cause mortality in PLHIV on antiretroviral therapy in Brazil. Competing risk regression to assess factors associated with CVD and all-cause mortality in the HIV-Brazil Cohort Study between 2003 and 2014. Among 5614 patients, the rate of CVD was 3.5 (95% confidence interval [95% CI] 2.9-4.3) per 1000 person-years. CVD was associated with older age (adjusted hazard ratio [aHR] 6.4 for ≥55 years vs. <35 years, 95% CI: 2.5-16.3, P < 0.01), black race (aHR 1.8 vs. white race, 95% CI: 1.0-3.1, P = 0.04), past CVD (aHR 3.0 vs. no past CVD, 95% CI: 1.4-6.2, P < 0.01), hypertension (aHR 1.8 vs. no hypertension, 95% CI: 1.0-3.1, P = 0.04), high-grade dyslipidemia (aHR 9.3 vs. no high-grade dyslipidemia, 95% CI: 6.0-14.6, P < 0.01), ever smoking (aHR 2.4 vs. never, 95% CI: 1.2-5.0, P = 0.02) and low nadir CD4 cell count (aHR 1.8 for 100-250 cells/mm3 vs. >250 cells/mm3 , 95% CI: 1.0-3.2, P = 0.05). The rate of death was 16.6 (95% CI: 15.1-18.3) per 1000 person-years. Death was strongly associated with having had a past CVD event (aHR 1.7 vs. no past CVD event, 95% CI: 1.1-2.7, P = 0.01). Traditional and HIV-specific factors associated with CVD among PLHIV in Brazil are similar to those identified among PLHIV in high-income countries. PLHIV in Brazil with a history of CVD have a high risk of death. CVD care and treatment remain priorities for PLHIV in Brazil as this population ages and antiretroviral therapy use expands.BrazilHIVAntiretroviral therapyCardiovascular diseaseMortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/41235/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCardiovascular disease_Valdilea_Veloso_INI_LapClin-AIDS_2020.pdfCardiovascular disease_Valdilea_Veloso_INI_LapClin-AIDS_2020.pdfapplication/pdf10236443https://www.arca.fiocruz.br/bitstream/icict/41235/2/Cardiovascular%20disease_Valdilea_Veloso_INI_LapClin-AIDS_2020.pdf6a82251e55011f38eaa73ddca78c3f68MD52TEXTCardiovascular disease_Valdilea_Veloso_INI_LapClin-AIDS_2020.pdf.txtCardiovascular disease_Valdilea_Veloso_INI_LapClin-AIDS_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Cardiovascular disease among people living with HIV in Brazil |
| title |
Cardiovascular disease among people living with HIV in Brazil |
| spellingShingle |
Cardiovascular disease among people living with HIV in Brazil Boettiger, David C. Brazil HIV Antiretroviral therapy Cardiovascular disease Mortality |
| title_short |
Cardiovascular disease among people living with HIV in Brazil |
| title_full |
Cardiovascular disease among people living with HIV in Brazil |
| title_fullStr |
Cardiovascular disease among people living with HIV in Brazil |
| title_full_unstemmed |
Cardiovascular disease among people living with HIV in Brazil |
| title_sort |
Cardiovascular disease among people living with HIV in Brazil |
| author |
Boettiger, David C. |
| author_facet |
Boettiger, David C. Escuder, Maria Mercedes Law, Matthew G. Veloso, Valdiléa G. Souza, Rosa A. Ikeda, Maria L. R. Alencastro, Paulo R. Tupinambás, Unai Brites, Carlos Grinsztejn, Beatriz Ggomes, Jackeline O. Ribeiro, Sayonara McGowan, Catherine C. Jayathilake, Karu Castilho, Jessica L. Grangeiro, Alexandre |
| author_role |
author |
| author2 |
Escuder, Maria Mercedes Law, Matthew G. Veloso, Valdiléa G. Souza, Rosa A. Ikeda, Maria L. R. Alencastro, Paulo R. Tupinambás, Unai Brites, Carlos Grinsztejn, Beatriz Ggomes, Jackeline O. Ribeiro, Sayonara McGowan, Catherine C. Jayathilake, Karu Castilho, Jessica L. Grangeiro, Alexandre |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Boettiger, David C. Escuder, Maria Mercedes Law, Matthew G. Veloso, Valdiléa G. Souza, Rosa A. Ikeda, Maria L. R. Alencastro, Paulo R. Tupinambás, Unai Brites, Carlos Grinsztejn, Beatriz Ggomes, Jackeline O. Ribeiro, Sayonara McGowan, Catherine C. Jayathilake, Karu Castilho, Jessica L. Grangeiro, Alexandre |
| dc.subject.en.pt_BR.fl_str_mv |
Brazil HIV Antiretroviral therapy Cardiovascular disease Mortality |
| topic |
Brazil HIV Antiretroviral therapy Cardiovascular disease Mortality |
| description |
2022-12-31 |
| publishDate |
2020 |
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2020-05-13T23:00:11Z |
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2020-05-13T23:00:11Z |
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2020 |
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BOETTIGER, David C. et al. Cardiovascular disease among people living with HIV in Brazil. Tropical Medicine and International Health, p. 1-22, 2020. |
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https://www.arca.fiocruz.br/handle/icict/41235 |
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1360-2276 |
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10.1111/tmi.13405 |
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BOETTIGER, David C. et al. Cardiovascular disease among people living with HIV in Brazil. Tropical Medicine and International Health, p. 1-22, 2020. 1360-2276 10.1111/tmi.13405 |
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Wiley |
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Wiley |
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