Splenectomy increases mortality in murine Trypanosoma cruzi infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8080 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil |
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Maioli, Tatiani UceliAssis, Frankcinéia Aparecida deVieira, Paula Melo de AbreuBorelli, PrimaveraSantiago, Helton da CostaAlves, R.Romanha, Álvaro JoséCarneiro, Cláudia MartinsFaria, Ana Maria Caetano de2014-07-25T17:47:52Z2014-07-25T17:47:52Z2011MAIOLI, Tatiani Uceli et al. Splenectomy increases mortality in murine Trypanosoma cruzi infection. Scand J Immunol, 73(1): 36-45. 20110300-947510.1111/j.1365-3083.2010.02478.xhttps://www.arca.fiocruz.br/handle/icict/8080engBlackwell Scientific PublicationsSplenectomy increases mortality in murine Trypanosoma cruzi infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, BrazilUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilThe spleen is a secondary lymphoid organ that harbours a variety of cells such as T and B lymphocytes and antigen-presenting cells important to immune response development. In this study, we evaluated the impact of spleen removal in the immune response to experimental Trypanosoma cruzi infection. C57BL/6 mice were infected with Y strain of the parasite and infection was followed daily. Mice that underwent splenectomy had fewer parasites in peripheral blood at the peak of infection; however, mortality was increased. Histological analysis of heart and liver tissues revealed an increased number of parasites and inflammatory infiltrates at these sites. Spleen removal was associated with reduction in IFN-γ and TNF-α production during infection as well as with a decrease in specific antibody secretion. Haematological disorders were also detected. Splenectomized mice exhibited severe anaemia and decreased bone marrow cell numbers. Our results indicate that spleen integrity is critical in T. cruzi infection for the immune response against the parasite, as well as for the control of bone marrow haematological function.Trypanosoma cruziChagas Disease/immunologyMiceInbred C57BLSpleen/immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSplenectomy increases mortality in murine Trypanosoma cruzi infection.pdfSplenectomy increases mortality in murine Trypanosoma cruzi infection.pdfapplication/pdf2254591https://www.arca.fiocruz.br/bitstream/icict/8080/1/Splenectomy%20increases%20mortality%20in%20murine%20Trypanosoma%20cruzi%20infection.pdf26aa16395bea35218ff0855f31186b85MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8080/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSplenectomy increases mortality in murine Trypanosoma cruzi infection.pdf.txtSplenectomy increases mortality in murine Trypanosoma cruzi infection.pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/8080/3/Splenectomy%20increases%20mortality%20in%20murine%20Trypanosoma%20cruzi%20infection.pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD53icict/80802018-04-06 08:43:55.313oai:www.arca.fiocruz.br:icict/8080TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:43:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Splenectomy increases mortality in murine Trypanosoma cruzi infection |
| title |
Splenectomy increases mortality in murine Trypanosoma cruzi infection |
| spellingShingle |
Splenectomy increases mortality in murine Trypanosoma cruzi infection Maioli, Tatiani Uceli Trypanosoma cruzi Chagas Disease/immunology Mice Inbred C57BL Spleen/immunology |
| title_short |
Splenectomy increases mortality in murine Trypanosoma cruzi infection |
| title_full |
Splenectomy increases mortality in murine Trypanosoma cruzi infection |
| title_fullStr |
Splenectomy increases mortality in murine Trypanosoma cruzi infection |
| title_full_unstemmed |
Splenectomy increases mortality in murine Trypanosoma cruzi infection |
| title_sort |
Splenectomy increases mortality in murine Trypanosoma cruzi infection |
| author |
Maioli, Tatiani Uceli |
| author_facet |
Maioli, Tatiani Uceli Assis, Frankcinéia Aparecida de Vieira, Paula Melo de Abreu Borelli, Primavera Santiago, Helton da Costa Alves, R. Romanha, Álvaro José Carneiro, Cláudia Martins Faria, Ana Maria Caetano de |
| author_role |
author |
| author2 |
Assis, Frankcinéia Aparecida de Vieira, Paula Melo de Abreu Borelli, Primavera Santiago, Helton da Costa Alves, R. Romanha, Álvaro José Carneiro, Cláudia Martins Faria, Ana Maria Caetano de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Maioli, Tatiani Uceli Assis, Frankcinéia Aparecida de Vieira, Paula Melo de Abreu Borelli, Primavera Santiago, Helton da Costa Alves, R. Romanha, Álvaro José Carneiro, Cláudia Martins Faria, Ana Maria Caetano de |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas Disease/immunology Mice Inbred C57BL Spleen/immunology |
| topic |
Trypanosoma cruzi Chagas Disease/immunology Mice Inbred C57BL Spleen/immunology |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil |
| publishDate |
2011 |
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2011 |
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2014-07-25T17:47:52Z |
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2014-07-25T17:47:52Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MAIOLI, Tatiani Uceli et al. Splenectomy increases mortality in murine Trypanosoma cruzi infection. Scand J Immunol, 73(1): 36-45. 2011 |
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https://www.arca.fiocruz.br/handle/icict/8080 |
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0300-9475 10.1111/j.1365-3083.2010.02478.x |
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MAIOLI, Tatiani Uceli et al. Splenectomy increases mortality in murine Trypanosoma cruzi infection. Scand J Immunol, 73(1): 36-45. 2011 0300-9475 10.1111/j.1365-3083.2010.02478.x |
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Blackwell Scientific Publications |
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Blackwell Scientific Publications |
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