Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30423 |
Resumo: | Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). |
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Luz, Nívea FariasCunha, Antonio Ricardo KhouriVan Weyenbergh, JohanZanette, Dalila LucíolaFiuza, Paloma Peixoto dos SantosNoronha, AlmerioBarral, Aldina Maria PradoBoaventura, Viviane SampaioPrates, Deboraci BritoChan, Francis Ka-MingAndrade, Bruno de BezerrilBorges, Valeria de Matos2018-12-07T16:54:31Z2018-12-07T16:54:31Z2018LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3042310.3389/fmicb.2018.02283Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Rega Institute for Medical Research. KU Leuven. Department of Microbiology and Immunology. Leuven, Belgium.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil.Duke University Medical Center. Department of Immunology. Durham, NC, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology.engFrontiers MediaRIPK3MLKLMacrófagoNecroptoseLeishmania braziliensisRIPK3MLKLMacrophageNecroptosisLeishmania braziliensisLeishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30423/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLuz NF. Leishimania Brasiliensis... 2018.pdfLuz NF. Leishimania Brasiliensis... 2018.pdfapplication/pdf1416218https://www.arca.fiocruz.br/bitstream/icict/30423/2/Luz%20NF.%20Leishimania%20Brasiliensis...%202018.pdfe8c3ff29f884d38354b401951f805bbbMD52TEXTLuz NF. Leishimania Brasiliensis... 2018.pdf.txtLuz NF. Leishimania Brasiliensis... 2018.pdf.txtExtracted texttext/plain32892https://www.arca.fiocruz.br/bitstream/icict/30423/3/Luz%20NF.%20Leishimania%20Brasiliensis...%202018.pdf.txt55eb5c0f9920a58659121724f9cd6acaMD53icict/304232023-03-15 14:34:15.428oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
| title |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
| spellingShingle |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression Luz, Nívea Farias RIPK3 MLKL Macrófago Necroptose Leishmania braziliensis RIPK3 MLKL Macrophage Necroptosis Leishmania braziliensis |
| title_short |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
| title_full |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
| title_fullStr |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
| title_full_unstemmed |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
| title_sort |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
| author |
Luz, Nívea Farias |
| author_facet |
Luz, Nívea Farias Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Zanette, Dalila Lucíola Fiuza, Paloma Peixoto dos Santos Noronha, Almerio Barral, Aldina Maria Prado Boaventura, Viviane Sampaio Prates, Deboraci Brito Chan, Francis Ka-Ming Andrade, Bruno de Bezerril Borges, Valeria de Matos |
| author_role |
author |
| author2 |
Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Zanette, Dalila Lucíola Fiuza, Paloma Peixoto dos Santos Noronha, Almerio Barral, Aldina Maria Prado Boaventura, Viviane Sampaio Prates, Deboraci Brito Chan, Francis Ka-Ming Andrade, Bruno de Bezerril Borges, Valeria de Matos |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Luz, Nívea Farias Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Zanette, Dalila Lucíola Fiuza, Paloma Peixoto dos Santos Noronha, Almerio Barral, Aldina Maria Prado Boaventura, Viviane Sampaio Prates, Deboraci Brito Chan, Francis Ka-Ming Andrade, Bruno de Bezerril Borges, Valeria de Matos |
| dc.subject.other.pt_BR.fl_str_mv |
RIPK3 MLKL Macrófago Necroptose Leishmania braziliensis |
| topic |
RIPK3 MLKL Macrófago Necroptose Leishmania braziliensis RIPK3 MLKL Macrophage Necroptosis Leishmania braziliensis |
| dc.subject.en.pt_BR.fl_str_mv |
RIPK3 MLKL Macrophage Necroptosis Leishmania braziliensis |
| description |
Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). |
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2018 |
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2018-12-07T16:54:31Z |
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2018-12-07T16:54:31Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018. |
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https://www.arca.fiocruz.br/handle/icict/30423 |
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1664-302X |
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10.3389/fmicb.2018.02283 |
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LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018. 1664-302X 10.3389/fmicb.2018.02283 |
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