Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.

Costa, Maria Fernanda Lima; Macinko, James; Mambrini, Juliana Vaz de Melo; Cesar, Cibele Comini; Peixoto, Sérgio William Viana; Magalhães, Wagner Carlos Santos; Horta, Bernardo Lessa; Barreto, Maurício Lima; Costa, Erico Castro; Firmo, Josélia Oliveira Araújo; Proietti, Fernando Augusto; Leal, ThiagoPeixoto; Rodrigues, Maira R; Pereira, Alexandre; Santos, Eduardo Tarazona

Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.

Detalhes bibliográficos
Autor(a) principal:	Costa, Maria Fernanda Lima
Data de Publicação:	2015
Outros Autores:	Macinko, James, Mambrini, Juliana Vaz de Melo, Cesar, Cibele Comini, Peixoto, Sérgio William Viana, Magalhães, Wagner Carlos Santos, Horta, Bernardo Lessa, Barreto, Maurício Lima, Costa, Erico Castro, Firmo, Josélia Oliveira Araújo, Proietti, Fernando Augusto, Leal, ThiagoPeixoto, Rodrigues, Maira R, Pereira, Alexandre, Santos, Eduardo Tarazona
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/13546
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil

Metadados do item

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spelling	Costa, Maria Fernanda LimaMacinko, JamesMambrini, Juliana Vaz de MeloCesar, Cibele CominiPeixoto, Sérgio William VianaMagalhães, Wagner Carlos SantosHorta, Bernardo LessaBarreto, Maurício LimaCosta, Erico CastroFirmo, Josélia Oliveira AraújoProietti, Fernando AugustoLeal, ThiagoPeixotoRodrigues, Maira RPereira, AlexandreSantos, Eduardo Tarazona2016-04-05T18:37:25Z2016-04-05T18:37:25Z2015COSTA, M. F. L. et al. Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. Plos One, v. 10, n. 12, p. e0144456, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1354610.1371/journal.pone.0144456engPublic Library of ScienceMortalidadeEtnografiaGenômicaGrupo de ancestralidade no continente africanoGrupo de ascendência continental européiaCondições socioeconômicasGenomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, BrasilUniversity of California. Fielding School of Public Health. Departments of Health Policy and Management and Community Health Sciences. Los Angeles, California, USAFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, BrasilUniversidade Federal de Minas Gerais. Departamento de Estatística. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, BrasilUniversidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Pelotas. Departamento de Medicina Social. Pelotas, RGS, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, BrasilUniversidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Instituto do Coração. São Paulo, SP, BrazilUniversidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilBACKGROUND: Self-rated health (SRH) has strong predictive value for mortality in different contexts and cultures, but there is inconsistent evidence on ethnoracial disparities in SRH in Latin America, possibly due to the complexity surrounding ethnoracial self-classification. MATERIALS/METHODS: We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual genomic proportions of African, European and Native American ancestry, and ethnoracial self-classification, with baseline and 10-year SRH trajectories in 1,311 community dwelling older Brazilians. We also examined whether genomic ancestry and ethnoracial self-classification affect the predictive value of SRH for subsequent mortality. RESULTS: European ancestry predominated among participants, followed by African and Native American (median = 84.0%, 9.6% and 5.3%, respectively); the prevalence of Non-White (Mixed and Black) was 39.8%. Persons at higher levels of African and Native American genomic ancestry, and those self-identified as Non-White, were more likely to report poor health than other groups, even after controlling for socioeconomic conditions and an array of self-reported and objective physical health measures. Increased risks for mortality associated with worse SRH trajectories were strong and remarkably similar (hazard ratio ~3) across all genomic ancestry and ethno-racial groups. CONCLUSIONS: Our results demonstrated for the first time that higher levels of African and Native American genomic ancestry-and the inverse for European ancestry-were strongly correlated with worse SRH in a Latin American admixed population. Both genomic ancestry and ethnoracial self-classification did not modify the strong association between baseline SRH or SRH trajectory, and subsequent mortality.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCosta ML Genomic....pdfCosta ML Genomic....pdfapplication/pdf480897https://www.arca.fiocruz.br/bitstream/icict/13546/2/Costa%20ML%20Genomic....pdf0b64c675828527fb0be9a987e225840aMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13546/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTCosta ML Genomic....pdf.txtCosta ML Genomic....pdf.txtExtracted texttext/plain32874https://www.arca.fiocruz.br/bitstream/icict/13546/4/Costa%20ML%20Genomic....pdf.txtefd13f8073b9b5a2278c0bb375ef0b1aMD54icict/135462023-08-03 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dc.title.pt_BR.fl_str_mv	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
title	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
spellingShingle	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. Costa, Maria Fernanda Lima Mortalidade Etnografia Genômica Grupo de ancestralidade no continente africano Grupo de ascendência continental européia Condições socioeconômicas
title_short	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
title_full	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
title_fullStr	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
title_full_unstemmed	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
title_sort	Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
author	Costa, Maria Fernanda Lima
author_facet	Costa, Maria Fernanda Lima Macinko, James Mambrini, Juliana Vaz de Melo Cesar, Cibele Comini Peixoto, Sérgio William Viana Magalhães, Wagner Carlos Santos Horta, Bernardo Lessa Barreto, Maurício Lima Costa, Erico Castro Firmo, Josélia Oliveira Araújo Proietti, Fernando Augusto Leal, ThiagoPeixoto Rodrigues, Maira R Pereira, Alexandre Santos, Eduardo Tarazona
author_role	author
author2	Macinko, James Mambrini, Juliana Vaz de Melo Cesar, Cibele Comini Peixoto, Sérgio William Viana Magalhães, Wagner Carlos Santos Horta, Bernardo Lessa Barreto, Maurício Lima Costa, Erico Castro Firmo, Josélia Oliveira Araújo Proietti, Fernando Augusto Leal, ThiagoPeixoto Rodrigues, Maira R Pereira, Alexandre Santos, Eduardo Tarazona
author2_role	author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Costa, Maria Fernanda Lima Macinko, James Mambrini, Juliana Vaz de Melo Cesar, Cibele Comini Peixoto, Sérgio William Viana Magalhães, Wagner Carlos Santos Horta, Bernardo Lessa Barreto, Maurício Lima Costa, Erico Castro Firmo, Josélia Oliveira Araújo Proietti, Fernando Augusto Leal, ThiagoPeixoto Rodrigues, Maira R Pereira, Alexandre Santos, Eduardo Tarazona
dc.subject.other.pt_BR.fl_str_mv	Mortalidade Etnografia Genômica Grupo de ancestralidade no continente africano Grupo de ascendência continental européia Condições socioeconômicas
topic	Mortalidade Etnografia Genômica Grupo de ancestralidade no continente africano Grupo de ascendência continental européia Condições socioeconômicas
description	Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2016-04-05T18:37:25Z
dc.date.available.fl_str_mv	2016-04-05T18:37:25Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	COSTA, M. F. L. et al. Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. Plos One, v. 10, n. 12, p. e0144456, 2015.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/13546
dc.identifier.issn.none.fl_str_mv	1932-6203
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pone.0144456
identifier_str_mv	COSTA, M. F. L. et al. Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. Plos One, v. 10, n. 12, p. e0144456, 2015. 1932-6203 10.1371/journal.pone.0144456
url	https://www.arca.fiocruz.br/handle/icict/13546
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
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Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.

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