Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20578 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Cézar, Rodrigo SCerqueira, Bruno Antonio VelosoPaz, Silvana de Souza daBarbosa, Cynara GomesMoura Neto, José Pereira deBarreto, José Henrique SilvaGonçalves, Marilda de Souza2017-08-10T18:45:49Z2017-08-10T18:45:49Z2015CEZAR, R. S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, p. 423–428, 2015.1077-4114https://www.arca.fiocruz.br/handle/icict/2057810.1097/MPH.0000000000000358engLippincott, Williams & WilkinsLeucemia linfoblástica agudaImunofenotipoInfânciaAcute lymphoblastic leukemiaImmunophenotypeChildhoodOutcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Department of Ciências da vida. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, BrasilHospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. Salvador, BA, BrasilThe aim of this study is to investigate the clinical, hematological, and immunophenotypic characteristics of Brazilian children with B-cell acute lymphoblastic leukemia (B-ALL) to identify prognostic biomarkers of the disease. Thirty-three children newly diagnosed with B-ALL were followed between March 2004 and December 2009. Information about the demographic profile, diagnosis, immunophenotype, clinical manifestations, and disease outcome were gathered from the patients' medical records. Of the 33 patients with B-ALL, 18 were male and 15 female. Eighteen patients were classified as high risk; 13 as low risk, and 2 as true low risk. The frequencies of cluster of differentiation (CD)10, CD19, and CD20 antigens were 69.7%, 81.8%, and 18.2%, respectively. Six patients (18.2%) had aberrant expression of myeloid antigens. At diagnosis, patients immunopositive for CD20 had elevated white blood cell counts (P = 0.018) and lower platelet counts (P = 0.017). The 6-year overall survival was 67.5%± 3.47%. Our results demonstrate the distinct immunophenotypic and prognostic characteristics of patients with B-ALL, which can be related to the Brazilian racial admixture. Consequently, these results will most likely aid in the selection of additional prognostic markers and their use in monitoring the clinical manifestations and treatment response among B-ALL patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20578/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCezar RS Outcome of B-cell....pdfCezar RS Outcome of B-cell....pdfapplication/pdf175207https://www.arca.fiocruz.br/bitstream/icict/20578/2/Cezar%20RS%20Outcome%20of%20B-cell....pdf122962f2f844b84a3acc8384268c7001MD52TEXTCezar RS Outcome of B-cell....pdf.txtCezar RS Outcome of B-cell....pdf.txtExtracted texttext/plain28231https://www.arca.fiocruz.br/bitstream/icict/20578/3/Cezar%20RS%20Outcome%20of%20B-cell....pdf.txt41c9db717208e20302679417a6d73f2cMD53icict/205782023-03-15 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| dc.title.pt_BR.fl_str_mv |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation |
| title |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation |
| spellingShingle |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation Cézar, Rodrigo S Leucemia linfoblástica aguda Imunofenotipo Infância Acute lymphoblastic leukemia Immunophenotype Childhood |
| title_short |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation |
| title_full |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation |
| title_fullStr |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation |
| title_full_unstemmed |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation |
| title_sort |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation |
| author |
Cézar, Rodrigo S |
| author_facet |
Cézar, Rodrigo S Cerqueira, Bruno Antonio Veloso Paz, Silvana de Souza da Barbosa, Cynara Gomes Moura Neto, José Pereira de Barreto, José Henrique Silva Gonçalves, Marilda de Souza |
| author_role |
author |
| author2 |
Cerqueira, Bruno Antonio Veloso Paz, Silvana de Souza da Barbosa, Cynara Gomes Moura Neto, José Pereira de Barreto, José Henrique Silva Gonçalves, Marilda de Souza |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Cézar, Rodrigo S Cerqueira, Bruno Antonio Veloso Paz, Silvana de Souza da Barbosa, Cynara Gomes Moura Neto, José Pereira de Barreto, José Henrique Silva Gonçalves, Marilda de Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Leucemia linfoblástica aguda Imunofenotipo Infância |
| topic |
Leucemia linfoblástica aguda Imunofenotipo Infância Acute lymphoblastic leukemia Immunophenotype Childhood |
| dc.subject.en.pt_BR.fl_str_mv |
Acute lymphoblastic leukemia Immunophenotype Childhood |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2015 |
| dc.date.issued.fl_str_mv |
2015 |
| dc.date.accessioned.fl_str_mv |
2017-08-10T18:45:49Z |
| dc.date.available.fl_str_mv |
2017-08-10T18:45:49Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
CEZAR, R. S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, p. 423–428, 2015. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20578 |
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1077-4114 |
| dc.identifier.doi.none.fl_str_mv |
10.1097/MPH.0000000000000358 |
| identifier_str_mv |
CEZAR, R. S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, p. 423–428, 2015. 1077-4114 10.1097/MPH.0000000000000358 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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