Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice

Bibliographic Details
Main Author: Lapa, J. S.
Publication Date: 2012
Other Authors: Saraiva, R. M., Hasslocher-Moreno, Alejandro Marcel, Georg, I., Souza, A. S., Xavier, S. S., Brasil, P. E. A. A.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/36509
Summary: 2020-10-17
id CRUZ_da6739786c67f8b45cfab163456b73cf
oai_identifier_str oai:www.arca.fiocruz.br:icict/36509
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Lapa, J. S.Saraiva, R. M.Hasslocher-Moreno, Alejandro MarcelGeorg, I.Souza, A. S.Xavier, S. S.Brasil, P. E. A. A.2019-10-17T12:33:17Z2019-10-17T12:33:17Z2012LAPA, J. S. et al. Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice. European Journal of Clinical Microbiology and Infectious Diseases, v. 31, p. 965-974, 2012.0934-9723https://www.arca.fiocruz.br/handle/icict/3650910.1007/s10096-011-1393-91435-4373engSpringer VerlagDealing with initial inconclusive serological results for chronic Chagas disease in clinical practiceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-10-17Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Most guidelines for Chagas disease recommend the performance of two serological tests in order to detect it. However, inconclusive results may arise from this strategy. The aim was to describe whether serological follow-up together with the patient’s clinical characteristics could clarify the outcome of patients with initial inconclusive test results. In this retrospective case series, all results of Chagas disease serological tests and outpatient visits recorded from 2004 to 2008 were screened for inclusion. The inclusion criterion was clinical suspicion of chronic Chagas disease and the exclusion criteria were previous diagnosis of Chagas disease, suspicion of acute Chagas disease, and serological tests with no corresponding medical evaluation. A total of 1,732 patients were analyzed. Chronic Chagas disease prevalence was 21.1%. After the initial set of serological tests, 2.9% of patients had inconclusive test results. Most of these patients had definite diagnosis after clinical follow-up and the repetition of serological tests in a new blood sample. Loss to follow-up while partaking in the diagnostic investigation reached 17.7%. The prevalence of initial inconclusive serological tests for chronic Chagas disease is low. Clinical evaluations and follow-up clarify the definite diagnosis. Noncompliance to follow-up is a frequent problem. Strategies to reduce inconclusive results and noncompliance are discussed.Chagas diseaseSerological resultsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36509/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Lapa_J_etal_INI_2012.pdfve_Lapa_J_etal_INI_2012.pdfapplication/pdf235275https://www.arca.fiocruz.br/bitstream/icict/36509/2/ve_Lapa_J_etal_INI_2012.pdf885cfae960540ef6897f7b2922cac674MD52TEXTve_Lapa_J_etal_INI_2012.pdf.txtve_Lapa_J_etal_INI_2012.pdf.txtExtracted texttext/plain38784https://www.arca.fiocruz.br/bitstream/icict/36509/3/ve_Lapa_J_etal_INI_2012.pdf.txt368435721b0ec25f33026875e4b701acMD53icict/365092023-03-08 09:53:35.983oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-08T12:53:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
title Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
spellingShingle Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
Lapa, J. S.
Chagas disease
Serological results
title_short Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
title_full Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
title_fullStr Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
title_full_unstemmed Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
title_sort Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice
author Lapa, J. S.
author_facet Lapa, J. S.
Saraiva, R. M.
Hasslocher-Moreno, Alejandro Marcel
Georg, I.
Souza, A. S.
Xavier, S. S.
Brasil, P. E. A. A.
author_role author
author2 Saraiva, R. M.
Hasslocher-Moreno, Alejandro Marcel
Georg, I.
Souza, A. S.
Xavier, S. S.
Brasil, P. E. A. A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lapa, J. S.
Saraiva, R. M.
Hasslocher-Moreno, Alejandro Marcel
Georg, I.
Souza, A. S.
Xavier, S. S.
Brasil, P. E. A. A.
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Serological results
topic Chagas disease
Serological results
description 2020-10-17
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-17T12:33:17Z
dc.date.available.fl_str_mv 2019-10-17T12:33:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAPA, J. S. et al. Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice. European Journal of Clinical Microbiology and Infectious Diseases, v. 31, p. 965-974, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36509
dc.identifier.issn.pt_BR.fl_str_mv 0934-9723
dc.identifier.doi.none.fl_str_mv 10.1007/s10096-011-1393-9
dc.identifier.eissn.none.fl_str_mv 1435-4373
identifier_str_mv LAPA, J. S. et al. Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice. European Journal of Clinical Microbiology and Infectious Diseases, v. 31, p. 965-974, 2012.
0934-9723
10.1007/s10096-011-1393-9
1435-4373
url https://www.arca.fiocruz.br/handle/icict/36509
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36509/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/36509/2/ve_Lapa_J_etal_INI_2012.pdf
https://www.arca.fiocruz.br/bitstream/icict/36509/3/ve_Lapa_J_etal_INI_2012.pdf.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
885cfae960540ef6897f7b2922cac674
368435721b0ec25f33026875e4b701ac
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324747470110720

Similar Items