Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37371 |
Resumo: | Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil. |
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Kauffman, CarlaGiacomin, Ana CarolineArossi, KelenPacheco, Leandra AndressaHoehne, LucéliaFreitas, Elisete Maria deMachado, Gérzia Maria de CarvalhoCavalheiro, Marilene Marcuzzo do CantoGnoatto, Simone Cristina BaggioEthur, Eduardo Miranda2019-11-26T11:22:40Z2019-11-26T11:22:40Z2019KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019.2175-9790https://www.arca.fiocruz.br/handle/icict/3737110.1590/s2175-97902019000217584engUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasLeishmania infantumMyrciaria plinioidesLeishmania amazonensisAtividade AntileishmanialLeishmania infantumMyrciaria plinioidesLeishmania amazonensisAntileishmanial activityAntileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Exatas e Tecnológicas. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC‑MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 µg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 µg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37371/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarileneMCavalheiro_etal_IOC_2019.pdfMarileneMCavalheiro_etal_IOC_2019.pdfapplication/pdf389480https://www.arca.fiocruz.br/bitstream/icict/37371/2/MarileneMCavalheiro_etal_IOC_2019.pdfb69b52dc72bbc14cc7f02cb9e26f1a93MD52TEXTMarileneMCavalheiro_etal_IOC_2019.pdf.txtMarileneMCavalheiro_etal_IOC_2019.pdf.txtExtracted texttext/plain32769https://www.arca.fiocruz.br/bitstream/icict/37371/3/MarileneMCavalheiro_etal_IOC_2019.pdf.txt2de030b4763357377915280a10b419c4MD53icict/373712020-04-14 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| dc.title.pt_BR.fl_str_mv |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil |
| title |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil |
| spellingShingle |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil Kauffman, Carla Leishmania infantum Myrciaria plinioides Leishmania amazonensis Atividade Antileishmanial Leishmania infantum Myrciaria plinioides Leishmania amazonensis Antileishmanial activity |
| title_short |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil |
| title_full |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil |
| title_fullStr |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil |
| title_full_unstemmed |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil |
| title_sort |
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil |
| author |
Kauffman, Carla |
| author_facet |
Kauffman, Carla Giacomin, Ana Caroline Arossi, Kelen Pacheco, Leandra Andressa Hoehne, Lucélia Freitas, Elisete Maria de Machado, Gérzia Maria de Carvalho Cavalheiro, Marilene Marcuzzo do Canto Gnoatto, Simone Cristina Baggio Ethur, Eduardo Miranda |
| author_role |
author |
| author2 |
Giacomin, Ana Caroline Arossi, Kelen Pacheco, Leandra Andressa Hoehne, Lucélia Freitas, Elisete Maria de Machado, Gérzia Maria de Carvalho Cavalheiro, Marilene Marcuzzo do Canto Gnoatto, Simone Cristina Baggio Ethur, Eduardo Miranda |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Kauffman, Carla Giacomin, Ana Caroline Arossi, Kelen Pacheco, Leandra Andressa Hoehne, Lucélia Freitas, Elisete Maria de Machado, Gérzia Maria de Carvalho Cavalheiro, Marilene Marcuzzo do Canto Gnoatto, Simone Cristina Baggio Ethur, Eduardo Miranda |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania infantum Myrciaria plinioides Leishmania amazonensis Atividade Antileishmanial |
| topic |
Leishmania infantum Myrciaria plinioides Leishmania amazonensis Atividade Antileishmanial Leishmania infantum Myrciaria plinioides Leishmania amazonensis Antileishmanial activity |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania infantum Myrciaria plinioides Leishmania amazonensis Antileishmanial activity |
| description |
Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil. |
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2019 |
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2019-11-26T11:22:40Z |
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2019-11-26T11:22:40Z |
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2019 |
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info:eu-repo/semantics/article |
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KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019. |
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https://www.arca.fiocruz.br/handle/icict/37371 |
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2175-9790 |
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10.1590/s2175-97902019000217584 |
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KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019. 2175-9790 10.1590/s2175-97902019000217584 |
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
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