Potential of KM+ lectin in immunization against Leishmania amazonensis infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2815 |
Resumo: | Este estudo foi financiado com bolsas de pesquisa do CNPq e CAPES. |
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Teixeira, Clarissa RomeroCavassani, Karen AngélicaGomes, Regis Bernardo BrandimTeixeira, Maria JâniaBarreira, Maria Cristina RoqueCavada, Benildo SousaSilva, João Santana daBarral, Aldina Maria PradoBarral Netto, Manoel2011-08-22T13:25:54Z2011-08-22T13:25:54Z2006TEIXEIRA, C. R. et al.Potential of KM+lectin in immunization against Leishmania amazonensis infection. Vaccine, v.24, n.15, p.3001–3008, abr. 2006.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/281510.1016/j.vaccine.2005.11.067Este estudo foi financiado com bolsas de pesquisa do CNPq e CAPES.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Medicina da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos. São Paulo, SP, BrasilUniversidade Federal do Ceará. Departamento de Bioquímica e Biologia Molecular. Biomol-Lab. Campus do Pici, Fortaleza, CE, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Medicina da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Medicina da Bahia. Salvador, BA, BrasilIn the present study we evaluated Canavalia brasiliensis (ConBr), Pisum arvense (PAA) and Artocarpus integrifolia (KM+) lectins as immunostimulatory molecules in vaccination against Leishmania amazonensis infection. Although they induced IFN- production, the combination of the lectins with SLA antigen did not lead to lesion reduction. However, parasite load was largely reduced in mice immunized with KM+ lectin and SLA. KM+ induced a smaller inflammatory reaction in the air pouch model and was able to inhibit differentiation of dendritic cells (BMDC), but to induce maturation by enhancing the expression of MHC II, CD80 and CD86. These observations indicate the modulatory role of plant lectins in leishmaniasis vaccination may be related to their action on the initial innate response.engElsevierLeishmaniaLectinaMedula óssea, células dendríticas derivadasLeishmaniaLectinBone-marrow-derived dendritic cells (BMDC)Adjuvantes ImunológicosEstruturas AnimaisAnimaisAntígenos de ProtozoáriosArtocarpusCanavaliaCélulas DendríticasFemininoAntígenos de Histocompatibilidade Classe IIInterferon gamaInterleucina-12LeishmaniaLeishmanioseLinfócitosMasculinoCamundongosCamundongos Endogâmicos BALB CLectinas de PlantasPotential of KM+ lectin in immunization against Leishmania amazonensis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALTeixeira_Cavassani_Gomes_etal.pdfTeixeira_Cavassani_Gomes_etal.pdfapplication/pdf342191https://www.arca.fiocruz.br/bitstream/icict/2815/1/Teixeira_Cavassani_Gomes_etal.pdf44737e02dc583cd41b1b48a2e3c76612MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2815/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTTeixeira_Cavassani_Gomes_etal.pdf.txtTeixeira_Cavassani_Gomes_etal.pdf.txtExtracted texttext/plain33668https://www.arca.fiocruz.br/bitstream/icict/2815/5/Teixeira_Cavassani_Gomes_etal.pdf.txt8597a99cd91d44d452c1db7c17a38761MD55THUMBNAILTeixeira_Cavassani_Gomes_etal.pdf.jpgTeixeira_Cavassani_Gomes_etal.pdf.jpgGenerated Thumbnailimage/jpeg1381https://www.arca.fiocruz.br/bitstream/icict/2815/4/Teixeira_Cavassani_Gomes_etal.pdf.jpgf500e5b08bd4f10258be1531f4f06779MD54icict/28152023-03-15 14:33:01.158oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
| title |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
| spellingShingle |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection Teixeira, Clarissa Romero Leishmania Lectina Medula óssea, células dendríticas derivadas Leishmania Lectin Bone-marrow-derived dendritic cells (BMDC) Adjuvantes Imunológicos Estruturas Animais Animais Antígenos de Protozoários Artocarpus Canavalia Células Dendríticas Feminino Antígenos de Histocompatibilidade Classe II Interferon gama Interleucina-12 Leishmania Leishmaniose Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Lectinas de Plantas |
| title_short |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
| title_full |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
| title_fullStr |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
| title_full_unstemmed |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
| title_sort |
Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
| author |
Teixeira, Clarissa Romero |
| author_facet |
Teixeira, Clarissa Romero Cavassani, Karen Angélica Gomes, Regis Bernardo Brandim Teixeira, Maria Jânia Barreira, Maria Cristina Roque Cavada, Benildo Sousa Silva, João Santana da Barral, Aldina Maria Prado Barral Netto, Manoel |
| author_role |
author |
| author2 |
Cavassani, Karen Angélica Gomes, Regis Bernardo Brandim Teixeira, Maria Jânia Barreira, Maria Cristina Roque Cavada, Benildo Sousa Silva, João Santana da Barral, Aldina Maria Prado Barral Netto, Manoel |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Teixeira, Clarissa Romero Cavassani, Karen Angélica Gomes, Regis Bernardo Brandim Teixeira, Maria Jânia Barreira, Maria Cristina Roque Cavada, Benildo Sousa Silva, João Santana da Barral, Aldina Maria Prado Barral Netto, Manoel |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania Lectina Medula óssea, células dendríticas derivadas |
| topic |
Leishmania Lectina Medula óssea, células dendríticas derivadas Leishmania Lectin Bone-marrow-derived dendritic cells (BMDC) Adjuvantes Imunológicos Estruturas Animais Animais Antígenos de Protozoários Artocarpus Canavalia Células Dendríticas Feminino Antígenos de Histocompatibilidade Classe II Interferon gama Interleucina-12 Leishmania Leishmaniose Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Lectinas de Plantas |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania Lectin Bone-marrow-derived dendritic cells (BMDC) |
| dc.subject.decs.pt_BR.fl_str_mv |
Adjuvantes Imunológicos Estruturas Animais Animais Antígenos de Protozoários Artocarpus Canavalia Células Dendríticas Feminino Antígenos de Histocompatibilidade Classe II Interferon gama Interleucina-12 Leishmania Leishmaniose Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Lectinas de Plantas |
| description |
Este estudo foi financiado com bolsas de pesquisa do CNPq e CAPES. |
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2006 |
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2006 |
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2011-08-22T13:25:54Z |
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2011-08-22T13:25:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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TEIXEIRA, C. R. et al.Potential of KM+lectin in immunization against Leishmania amazonensis infection. Vaccine, v.24, n.15, p.3001–3008, abr. 2006. |
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https://www.arca.fiocruz.br/handle/icict/2815 |
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0264-410X |
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10.1016/j.vaccine.2005.11.067 |
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TEIXEIRA, C. R. et al.Potential of KM+lectin in immunization against Leishmania amazonensis infection. Vaccine, v.24, n.15, p.3001–3008, abr. 2006. 0264-410X 10.1016/j.vaccine.2005.11.067 |
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Elsevier |
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