Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Dantas, Marina Loyola
Data de Publicação: 2014
Outros Autores: Oliveira, Juliana Menezes Gomes Cabral de, Carvalho, Lucas Pedreira de, Passos, Sara Timóteo, Queiroz, Adriano, Guimarães, Luiz Henrique, Machado, Paulo Roberto, Carvalho Filho, Edgar Marcelino, Arruda, Sérgio Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7588
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
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spelling Dantas, Marina LoyolaOliveira, Juliana Menezes Gomes Cabral deCarvalho, Lucas Pedreira dePassos, Sara TimóteoQueiroz, AdrianoGuimarães, Luiz HenriqueMachado, Paulo RobertoCarvalho Filho, Edgar MarcelinoArruda, Sérgio Marcos2014-05-06T19:24:30Z2014-05-06T19:24:30Z2014DANTAS, M. L. ET AL. Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 109, n. 2, p. 202-209, 2014.0074-0276https://www.arca.fiocruz.br/handle/icict/758810.1590/0074-0276130154engFiocruzComparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilCutaneous leishmaniasis (CL) is the most frequent clinical form of tegumentary leishmaniasis and is characterised by a single or a few ulcerated skin lesions that may disseminate into multiple ulcers and papules, which characterise disseminated leishmaniasis (DL). In this study, cells were quantified using immunohistochemistry and haematoxylin and eosin staining (CD4+, CD68+, CD20+, plasma cells and neutrophils) and histopathology was used to determine the level of inflammation in biopsies from patients with early CL, late CL and DL (ulcers and papules). The histopathology showed differences in the epidermis between the papules and ulcers from DL. An analysis of the cells present in the tissues showed similarities between the ulcers from localised CL (LCL) and DL. The papules had fewer CD4+ T cells than the DL ulcers. Although both CD4+ cells and macrophages contribute to inflammation in early CL, macrophages are the primary cell type associated with inflammation intensity in late ulcers. The higher frequency of CD20+ cells and plasma cells in lesions demonstrates the importance of B cells in the pathogenesis of leishmaniasis. The number of neutrophils was the same in all of the analysed groups. A comparison between the ulcers from LCL and DL and the early ulcers and papules shows that few differences between these two clinical forms can be distinguished by observing only the tissue.LeishmaniasisDisseminated leishmaniasisHistopathological aspectsInflammationInflammatory cellsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDantas ML Comparative analysis....pdfDantas ML Comparative analysis....pdfapplication/pdf1011338https://www.arca.fiocruz.br/bitstream/icict/7588/1/Dantas%20ML%20Comparative%20analysis....pdfc1094540c906cc97d1310c70bc1d3bf8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7588/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTDantas ML Comparative analysis....pdf.txtDantas ML Comparative analysis....pdf.txtExtracted texttext/plain35254https://www.arca.fiocruz.br/bitstream/icict/7588/5/Dantas%20ML%20Comparative%20analysis....pdf.txt5e78032e1a6d0e40bb797e97a8cc8172MD55THUMBNAILDantas ML Comparative analysis....pdf.jpgDantas ML Comparative analysis....pdf.jpgGenerated Thumbnailimage/jpeg2275https://www.arca.fiocruz.br/bitstream/icict/7588/4/Dantas%20ML%20Comparative%20analysis....pdf.jpgc5bf7d95716c0f6fc28d7f2146d6a27eMD54icict/75882023-03-15 14:33:17.44oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
title Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
spellingShingle Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
Dantas, Marina Loyola
Leishmaniasis
Disseminated leishmaniasis
Histopathological aspects
Inflammation
Inflammatory cells
title_short Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
title_full Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
title_fullStr Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
title_full_unstemmed Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
title_sort Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
author Dantas, Marina Loyola
author_facet Dantas, Marina Loyola
Oliveira, Juliana Menezes Gomes Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Guimarães, Luiz Henrique
Machado, Paulo Roberto
Carvalho Filho, Edgar Marcelino
Arruda, Sérgio Marcos
author_role author
author2 Oliveira, Juliana Menezes Gomes Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Guimarães, Luiz Henrique
Machado, Paulo Roberto
Carvalho Filho, Edgar Marcelino
Arruda, Sérgio Marcos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dantas, Marina Loyola
Oliveira, Juliana Menezes Gomes Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Guimarães, Luiz Henrique
Machado, Paulo Roberto
Carvalho Filho, Edgar Marcelino
Arruda, Sérgio Marcos
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Disseminated leishmaniasis
Histopathological aspects
Inflammation
Inflammatory cells
topic Leishmaniasis
Disseminated leishmaniasis
Histopathological aspects
Inflammation
Inflammatory cells
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-05-06T19:24:30Z
dc.date.available.fl_str_mv 2014-05-06T19:24:30Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DANTAS, M. L. ET AL. Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 109, n. 2, p. 202-209, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7588
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-0276130154
identifier_str_mv DANTAS, M. L. ET AL. Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 109, n. 2, p. 202-209, 2014.
0074-0276
10.1590/0074-0276130154
url https://www.arca.fiocruz.br/handle/icict/7588
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz
publisher.none.fl_str_mv Fiocruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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