Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31806 |
Resumo: | Translational Genomics Research Institute-North. Division of Pathogen Genomics. Flagstaff, AZ, USA / University of Brasília. Department of Cell Biology. Brasilia, DF, Brazil. |
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Teixeira, Marcus de M.Patané, José S. L.Taylor, Maria L.Gómez, Beatriz L.Theodoro, Raquel C.Hoog, Sybren deEngelthaler, David M.Zancopé-Oliveira, Rosely M.Felipe, Maria S. S.Barker, Bridget M.2019-02-21T14:12:04Z2019-02-21T14:12:04Z2016TEIXEIRA, Marcus de M. et al. Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma. Plos Neglected Tropical Diseases, p. 1-20, 1 June, 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/3180610.1371/journal.pntd.00047321935-2735engPublic Library of ScienceWorldwide phylogenetic distributions and population dynamics of the genus Histoplasmainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTranslational Genomics Research Institute-North. Division of Pathogen Genomics. Flagstaff, AZ, USA / University of Brasília. Department of Cell Biology. Brasilia, DF, Brazil.University of São Paulo. Department of Biochemistry. São Paulo, SP, Brazil.National Autonomous University of Mexico. Department of Microbiology and Parasitology. Mexico City, Mexico.Corporación para Investigaciones Biológicas. Medellín, Colombia.Federal University of Rio Grande do Norte. Institute of Tropical Medicine. Department of Cell Biology and Genetics. Natal, BrazilCBS-KNAW Fungal Biodiversity Centre. Utrecht, Netherlands.Translational Genomics Research Institute-North. Division of Pathogen Genomics. Flagstaff, AZ, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, Brasil.University of Brasília. Department of Cell Biology. Brasilia, DF, Brazil.Translational Genomics Research Institute-North. Division of Pathogen Genomics. Flagstaff, AZ, USA.Background: Histoplasma capsulatum comprises a worldwide complex of saprobiotic fungi mainly found in nitrogen/phosphate (often bird guano) enriched soils. The microconidia of Histoplasma species may be inhaled by mammalian hosts, and is followed by a rapid conversion to yeast that can persist in host tissues causing histoplasmosis, a deep pulmonary/systemic mycosis. Histoplasma capsulatum sensu lato is a complex of at least eight clades geographically distributed as follows: Australia, Netherlands, Eurasia, North American classes 1 and 2 (NAm 1 and NAm 2), Latin American groups A and B (LAm A and LAm B) and Africa. With the exception of the Eurasian cluster, those clades are considered phylogenetic species. Methodology/Principal Findings: Increased Histoplasma sampling (n = 234) resulted in the revision of the phylogenetic distribution and population structure using 1,563 aligned nucleotides from four protein-coding regions. The LAm B clade appears to be divided into at least two highly supported clades, which are geographically restricted to either Colombia/Argentina or Brazil respectively. Moreover, a complex population genetic structure was identified within LAm A clade supporting multiple monophylogenetic species, which could be driven by rapid host or environmental adaptation (~0.5 MYA). We found two divergent clades, which include Latin American isolates (newly named as LAm A1 and LAm A2), harboring a cryptic cluster in association with bats. Conclusions/Significance: At least six new phylogenetic species are proposed in the Histoplasma species complex supported by different phylogenetic and population genetics methods, comprising LAm A1, LAm A2, LAm B1, LAm B2, RJ and BAC-1 phylogenetic species. The genetic isolation of Histoplasma could be a result of differential dispersion potential of naturally infected bats and other mammals. In addition, the present study guides isolate selection for future population genomics and genome wide association studies in this important pathogen complex.Histoplasma capsulatumPhylogeneticinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31806/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Teixeira_Marcus_etal_INI_2016.pdfve_Teixeira_Marcus_etal_INI_2016.pdfapplication/pdf1289612https://www.arca.fiocruz.br/bitstream/icict/31806/2/ve_Teixeira_Marcus_etal_INI_2016.pdf9bdff083b5ed242adea0746751b2b957MD52TEXTve_Teixeira_Marcus_etal_INI_2016.pdf.txtve_Teixeira_Marcus_etal_INI_2016.pdf.txtExtracted texttext/plain77508https://www.arca.fiocruz.br/bitstream/icict/31806/3/ve_Teixeira_Marcus_etal_INI_2016.pdf.txt5d94a1ce7a0b8ba63fda51c519697896MD53icict/318062019-02-22 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| dc.title.pt_BR.fl_str_mv |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma |
| title |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma |
| spellingShingle |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma Teixeira, Marcus de M. Histoplasma capsulatum Phylogenetic |
| title_short |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma |
| title_full |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma |
| title_fullStr |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma |
| title_full_unstemmed |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma |
| title_sort |
Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma |
| author |
Teixeira, Marcus de M. |
| author_facet |
Teixeira, Marcus de M. Patané, José S. L. Taylor, Maria L. Gómez, Beatriz L. Theodoro, Raquel C. Hoog, Sybren de Engelthaler, David M. Zancopé-Oliveira, Rosely M. Felipe, Maria S. S. Barker, Bridget M. |
| author_role |
author |
| author2 |
Patané, José S. L. Taylor, Maria L. Gómez, Beatriz L. Theodoro, Raquel C. Hoog, Sybren de Engelthaler, David M. Zancopé-Oliveira, Rosely M. Felipe, Maria S. S. Barker, Bridget M. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Teixeira, Marcus de M. Patané, José S. L. Taylor, Maria L. Gómez, Beatriz L. Theodoro, Raquel C. Hoog, Sybren de Engelthaler, David M. Zancopé-Oliveira, Rosely M. Felipe, Maria S. S. Barker, Bridget M. |
| dc.subject.en.pt_BR.fl_str_mv |
Histoplasma capsulatum Phylogenetic |
| topic |
Histoplasma capsulatum Phylogenetic |
| description |
Translational Genomics Research Institute-North. Division of Pathogen Genomics. Flagstaff, AZ, USA / University of Brasília. Department of Cell Biology. Brasilia, DF, Brazil. |
| publishDate |
2016 |
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2016 |
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2019-02-21T14:12:04Z |
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2019-02-21T14:12:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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TEIXEIRA, Marcus de M. et al. Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma. Plos Neglected Tropical Diseases, p. 1-20, 1 June, 2016. |
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https://www.arca.fiocruz.br/handle/icict/31806 |
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1935-2727 |
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10.1371/journal.pntd.0004732 |
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1935-2735 |
| identifier_str_mv |
TEIXEIRA, Marcus de M. et al. Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma. Plos Neglected Tropical Diseases, p. 1-20, 1 June, 2016. 1935-2727 10.1371/journal.pntd.0004732 1935-2735 |
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Public Library of Science |
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