Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept

Detalhes bibliográficos
Autor(a) principal: Melo, Christianne Bandeira
Data de Publicação: 1997
Outros Autores: Cordeiro, Renato S. B., Silva, Patrícia M. R., Martins, Marco A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43905
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
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spelling Melo, Christianne BandeiraCordeiro, Renato S. B.Silva, Patrícia M. R.Martins, Marco A.2020-10-09T17:25:26Z2020-10-09T17:25:26Z1997MELO, Christiane Bandeira et al. Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept. Memórias do Instituto Oswaldo Cruz, v. 92, Supl. 2, p. 37-43, 1997.0074-0276https://www.arca.fiocruz.br/handle/icict/4390510.1590/S0074-027619970008000071678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.EosinophilInflamação e pleurisiaProstaglandinasAlergiaEosinophilProstaglandinsAllergyInflammation and pleurisyModulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Conceptinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.The eosinophilic response has been identified as a key alteration in the pathogenesis of asthma and other allergic diseases. A close-correlation between disease severity and eosinophilia, and the eosinophil ability to provide toxic and pro-inflammatory agents are the major elements supporting the interpretation that there is indeed a causal relationship between these phenomena. Nevertheless, controversy still persists since some studies have clearly demonstrated that eosinophil infiltration is not necessarily accompanied by tissue damage or hyperresponsiveness. In addition, there are some examples in the literature in which such alterations are not modified following abrogation of eosinophil influx. In this review it will be argued, based on a model of IgE-dependent pleurisy, that eosinophil infiltration can be associated with down-regulation of allergic inflammatory response. The potential mechanism by which eosinophils could be acting as a immunomodulatory cells in this particular system will also be assessed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43905/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarcoAurelio_Martins_etal_IOC_1997.pdfMarcoAurelio_Martins_etal_IOC_1997.pdfapplication/pdf101328https://www.arca.fiocruz.br/bitstream/icict/43905/2/MarcoAurelio_Martins_etal_IOC_1997.pdf345112958220015c235d90b8a7d91f50MD52TEXTMarcoAurelio_Martins_etal_IOC_1997.pdf.txtMarcoAurelio_Martins_etal_IOC_1997.pdf.txtExtracted texttext/plain31300https://www.arca.fiocruz.br/bitstream/icict/43905/3/MarcoAurelio_Martins_etal_IOC_1997.pdf.txt908d3056edbc3acc5a7e070f3f447b8aMD53icict/439052020-10-10 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dc.title.pt_BR.fl_str_mv Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
title Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
spellingShingle Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
Melo, Christianne Bandeira
Eosinophil
Inflamação e pleurisia
Prostaglandinas
Alergia
Eosinophil
Prostaglandins
Allergy
Inflammation and pleurisy
title_short Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
title_full Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
title_fullStr Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
title_full_unstemmed Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
title_sort Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept
author Melo, Christianne Bandeira
author_facet Melo, Christianne Bandeira
Cordeiro, Renato S. B.
Silva, Patrícia M. R.
Martins, Marco A.
author_role author
author2 Cordeiro, Renato S. B.
Silva, Patrícia M. R.
Martins, Marco A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Melo, Christianne Bandeira
Cordeiro, Renato S. B.
Silva, Patrícia M. R.
Martins, Marco A.
dc.subject.other.pt_BR.fl_str_mv Eosinophil
Inflamação e pleurisia
Prostaglandinas
Alergia
topic Eosinophil
Inflamação e pleurisia
Prostaglandinas
Alergia
Eosinophil
Prostaglandins
Allergy
Inflammation and pleurisy
dc.subject.en.pt_BR.fl_str_mv Eosinophil
Prostaglandins
Allergy
Inflammation and pleurisy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2020-10-09T17:25:26Z
dc.date.available.fl_str_mv 2020-10-09T17:25:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELO, Christiane Bandeira et al. Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept. Memórias do Instituto Oswaldo Cruz, v. 92, Supl. 2, p. 37-43, 1997.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43905
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761997000800007
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MELO, Christiane Bandeira et al. Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept. Memórias do Instituto Oswaldo Cruz, v. 92, Supl. 2, p. 37-43, 1997.
0074-0276
10.1590/S0074-02761997000800007
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43905
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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