Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line

Detalhes bibliográficos
Autor(a) principal: Gomide, Mayna da Silveira
Data de Publicação: 2016
Outros Autores: Lemos, Fernanda, Reis, Daniele, José, Gustavo, Lopes, Miriam, Machado, Marco Antônio, Alves, Tânia Maria de Almeida, Coelho, Cíntia Marques
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20579
Resumo: Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Biologia. Juiz de Fora, MG, Brasil.
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spelling Gomide, Mayna da SilveiraLemos, FernandaReis, DanieleJosé, GustavoLopes, MiriamMachado, Marco AntônioAlves, Tânia Maria de AlmeidaCoelho, Cíntia Marques2017-08-10T19:06:21Z2017-08-10T19:06:21Z2016GOMIDE, Mayna da Silveira, et al. Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line. Rev. bras. farmacogn., v. 26, n. 5, p. 627-633, 2016.0102-695https://www.arca.fiocruz.br/handle/icict/2057910.1016/j.bjp.2016.04.003engSociedade Brasileira de Farmacognosiacancer coloretalColorectal cancerCT26.WTLippia essential oilMicroRNACell cycle phasesIdentification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell lineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Biologia. Juiz de Fora, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Farmacologia. Belo Horizonte, MG, Brasil.Centro Nacional de Pesquisa de Gado de Leite. Empresa Brasileira de Pesquisa Agropecuária. Laboratório de Genética Molecular. Brasília, DF, Brasil.Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Farmacologia. Belo Horizonte, MG, Brasil.Centro Nacional de Pesquisa de Gado de Leite. Empresa Brasileira de Pesquisa Agropecuária. Laboratório de Genética Molecular. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Biologia. Juiz de Fora, MG, Brasil / Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.In spite of advances in colorectal cancer treatments, approximately 1.4 million new global cases are estimated for 2015. In this sense, Brazilian plant diversity offers a multiplicity of essential oils as prospective novel anticancer compounds. This study aimed to evaluate the antiproliferative effect of the essential oils from four Lippia species in CT26.WT colon tumor cells, as a measurement of cell cycle phase distribution and microRNA expression. CT26.WT showed cell cycle arrest at G2/M phase after treatment with 100 µg/ml of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Lippia sidoides Cham., and Lippia lacunosa Mart. & Schauer, Verbenaceae, essential oils and, at the same concentration, Lippia rotundifolia Cham. essential oil caused an augment of G0/G1 phase. The miRNA expression profiling shows change of expression in key oncogenic miRNAs genes after treatment. Our findings suggest growth inhibition mechanisms for all four essential oils on CT26.WT cells involving direct or indirect interference on cell cycle arrest and/or oncogenic miRNAs expression.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/20579/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIdentification of dysregulated microRNA .pdfIdentification of dysregulated microRNA .pdfapplication/pdf4787417https://www.arca.fiocruz.br/bitstream/icict/20579/2/Identification%20of%20dysregulated%20microRNA%20.pdfba6f7703dab4e339972debb8f3c503f6MD52TEXTIdentification of dysregulated microRNA .pdf.txtIdentification of dysregulated microRNA .pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
title Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
spellingShingle Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
Gomide, Mayna da Silveira
cancer coloretal
Colorectal cancer
CT26.WT
Lippia essential oil
MicroRNA
Cell cycle phases
title_short Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
title_full Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
title_fullStr Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
title_full_unstemmed Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
title_sort Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
author Gomide, Mayna da Silveira
author_facet Gomide, Mayna da Silveira
Lemos, Fernanda
Reis, Daniele
José, Gustavo
Lopes, Miriam
Machado, Marco Antônio
Alves, Tânia Maria de Almeida
Coelho, Cíntia Marques
author_role author
author2 Lemos, Fernanda
Reis, Daniele
José, Gustavo
Lopes, Miriam
Machado, Marco Antônio
Alves, Tânia Maria de Almeida
Coelho, Cíntia Marques
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomide, Mayna da Silveira
Lemos, Fernanda
Reis, Daniele
José, Gustavo
Lopes, Miriam
Machado, Marco Antônio
Alves, Tânia Maria de Almeida
Coelho, Cíntia Marques
dc.subject.other.pt_BR.fl_str_mv cancer coloretal
topic cancer coloretal
Colorectal cancer
CT26.WT
Lippia essential oil
MicroRNA
Cell cycle phases
dc.subject.en.pt_BR.fl_str_mv Colorectal cancer
CT26.WT
Lippia essential oil
MicroRNA
Cell cycle phases
description Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Biologia. Juiz de Fora, MG, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-08-10T19:06:21Z
dc.date.available.fl_str_mv 2017-08-10T19:06:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMIDE, Mayna da Silveira, et al. Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line. Rev. bras. farmacogn., v. 26, n. 5, p. 627-633, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20579
dc.identifier.issn.pt_BR.fl_str_mv 0102-695
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjp.2016.04.003
identifier_str_mv GOMIDE, Mayna da Silveira, et al. Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line. Rev. bras. farmacogn., v. 26, n. 5, p. 627-633, 2016.
0102-695
10.1016/j.bjp.2016.04.003
url https://www.arca.fiocruz.br/handle/icict/20579
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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