HIV-1 binding and neutralizing antibodies of injecting drug users

• Autor(a) principal: Reis, Elaine Priscilla Ouverney
• Data de Publicação: 2005
• Outros Autores: Teixeira, Sylvia Lopes Maia, Jesus, Carlos Silva de, Vilas-Boas Hacker, Mariana de Andrea, Morgado, Mariza Gonçalves, Bastos, Francisco Inácio Pinkusfeld Monteiro, Bongertz, Vera
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
• Texto Completo: https://www.arca.fiocruz.br/handle/icict/652
• topic: HIV-1; Injecting drug users; Antibodies; Neutralization

Previous studies have demonstrated a stronger seroreactivity against some synthetic peptides responsible for inducing neutralizing antibodies in injecting drug observed for plasma from the S group (15/23) than from the IDU group(15/47, P = 0.0108. No correlation between neutralization and seroreactivity with the peptides tested was observed. These results suggest that an important factor responsible for the extensive and broad humoral immune response observed in IDU is their infection route. There was very little difference in neutralizing antibody response between the IDU and S groups despite their differences in seroreactivity and health status.