Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/34633 |
Resumo: | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 015/22031-0 to S.S. and N.M., Grant 2018/09948-0 to N.M.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). SS and M.S are the recipients of a fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
| id |
CRUZ_e2d8214dbe1fb82c29259f4697888ed0 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/34633 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Bastos, Tanira MatutinoRusso, Helena MannochioMoretti, Nilmar SilvioSchenkman, SergioMarcourt, LaurenceGupta, Mahabir PrashadWolfender, Jean-LucQueiroz, Emerson FerreiraSoares, Milena Botelho Pereira2019-08-06T17:59:50Z2019-08-06T17:59:50Z2019BASTOS,Tanira Matutino et al. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules, v. 24, p. 1-13, 2019.1420-3049https://www.arca.fiocruz.br/handle/icict/3463310.3390/molecules24071299Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 015/22031-0 to S.S. and N.M., Grant 2018/09948-0 to N.M.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). SS and M.S are the recipients of a fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.Universidade Federal de São Paulo. Departmento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Departmento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.University of Panama. College of Pharmacy. Center for Pharmacognostic Research on Panamanian Flora. Panama, Panama.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets for the identification of novel bioactive compounds against the parasite and with low toxicity. Silent information regulator 2 (Sir2) enzymes, or sirtuins, have emerged as attractive targets for the development of novel antitrypanosomatid agents. In the present work, we evaluated the inhibitory effect of natural compounds isolated from cashew nut (Anacardium occidentale, L. Anacardiaceae) against the target enzymes TcSir2rp1 and TcSir2rp3 as well as the parasite. Two derivates of cardol (1, 2), cardanol (3, 4), and anacardic acid (5, 6) were investigated. The two anacardic acids (5, 6) inhibited both TcSir2rp1 and TcSir2rp3, while the cardol compound (2) inhibited only TcSir2rp1. The most potent sirtuin inhibitor active against the parasite was the cardol compound (2), with an EC50 value of 12.25 µM, similar to that of benznidazole. Additionally, compounds (1, 4), which were inactive against the sirtuin targets, presented anti-T. cruzi effects. In conclusion, our results showed the potential of Anacardium occidentale compounds for the development of potential sirtuin inhibitors and anti-Trypanosoma cruzi agents.engMDPITrypanosoma cruziSirtuinsAnacardium occidentaleDescoberta de drogasTrypanosoma cruziSirtuinsAnacardium occidentaleDrug discoveryChemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34633/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBastos, T.M. Chemical Constituents..2019.pdfBastos, T.M. Chemical Constituents..2019.pdfapplication/pdf2058509https://www.arca.fiocruz.br/bitstream/icict/34633/2/Bastos%2c%20T.M.%20Chemical%20Constituents..2019.pdf1a65d1df64e67868d881ad58bda54db6MD52TEXTBastos, T.M. Chemical Constituents..2019.pdf.txtBastos, T.M. Chemical Constituents..2019.pdf.txtExtracted texttext/plain51332https://www.arca.fiocruz.br/bitstream/icict/34633/3/Bastos%2c%20T.M.%20Chemical%20Constituents..2019.pdf.txt854bfd9fb04e762aac8d2cf473b0f863MD53icict/346332023-03-15 14:34:18.193oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins |
| title |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins |
| spellingShingle |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins Bastos, Tanira Matutino Trypanosoma cruzi Sirtuins Anacardium occidentale Descoberta de drogas Trypanosoma cruzi Sirtuins Anacardium occidentale Drug discovery |
| title_short |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins |
| title_full |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins |
| title_fullStr |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins |
| title_full_unstemmed |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins |
| title_sort |
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins |
| author |
Bastos, Tanira Matutino |
| author_facet |
Bastos, Tanira Matutino Russo, Helena Mannochio Moretti, Nilmar Silvio Schenkman, Sergio Marcourt, Laurence Gupta, Mahabir Prashad Wolfender, Jean-Luc Queiroz, Emerson Ferreira Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Russo, Helena Mannochio Moretti, Nilmar Silvio Schenkman, Sergio Marcourt, Laurence Gupta, Mahabir Prashad Wolfender, Jean-Luc Queiroz, Emerson Ferreira Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bastos, Tanira Matutino Russo, Helena Mannochio Moretti, Nilmar Silvio Schenkman, Sergio Marcourt, Laurence Gupta, Mahabir Prashad Wolfender, Jean-Luc Queiroz, Emerson Ferreira Soares, Milena Botelho Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Sirtuins Anacardium occidentale Descoberta de drogas |
| topic |
Trypanosoma cruzi Sirtuins Anacardium occidentale Descoberta de drogas Trypanosoma cruzi Sirtuins Anacardium occidentale Drug discovery |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Sirtuins Anacardium occidentale Drug discovery |
| description |
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 015/22031-0 to S.S. and N.M., Grant 2018/09948-0 to N.M.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). SS and M.S are the recipients of a fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
| publishDate |
2019 |
| dc.date.accessioned.fl_str_mv |
2019-08-06T17:59:50Z |
| dc.date.available.fl_str_mv |
2019-08-06T17:59:50Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
BASTOS,Tanira Matutino et al. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules, v. 24, p. 1-13, 2019. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/34633 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1420-3049 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/molecules24071299 |
| identifier_str_mv |
BASTOS,Tanira Matutino et al. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules, v. 24, p. 1-13, 2019. 1420-3049 10.3390/molecules24071299 |
| url |
https://www.arca.fiocruz.br/handle/icict/34633 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/34633/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/34633/2/Bastos%2c%20T.M.%20Chemical%20Constituents..2019.pdf https://www.arca.fiocruz.br/bitstream/icict/34633/3/Bastos%2c%20T.M.%20Chemical%20Constituents..2019.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 1a65d1df64e67868d881ad58bda54db6 854bfd9fb04e762aac8d2cf473b0f863 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1794075535408627712 |