Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40109 |
Resumo: | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. |
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Correa, AlejandroOttoboni, Gabriel SallesSenegaglia, Alexandra CristinaCapriglione, Luiz Guilherme AchcarMiyague, Nelson ItiroLeite, Lidiane Maria BoldriniJamur, Valderez RavaglioRebelatto, Carmen Lúcia KuniyoshiOlandoski, MárciaBrofman, Paulo Roberto Slud2020-02-20T18:31:35Z2020-02-20T18:31:35Z2018CORREA, Alejandro et al. Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction. Stem Cells International, p. 1–11, 2018.1687-9678https://www.arca.fiocruz.br/handle/icict/4010910.1155/2018/54124781687-9678porHindawiExpanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarctioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pharmacological approaches are partially effective in limiting infarct size. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs) CD133+ have opened new perspectives for the treatment of ischemic areas after infarction. This preclinical study evaluated the effect of intramyocardial transplantation of purified or expanded human umbilical cord blood-derived CD133+ cells on the recovery of rats following acute myocardial infarction (AMI). Histology studies, electrocardiogram, and fluorescence in situ hybridization (FISH) were used to evaluate heart recovery. Purified CD133+ cells, enriched in endothelial progenitor cells, when expanded in vitro acquired an endothelial-like cell phenotype expressing CD31 and von Willebrand factor (vWF). The group of infarcted rats that received expanded CD133+ cells had a more significant recovery of contraction performance and less heart remodeling than the group that received purified CD133+ cells. Either purified or expanded CD133+ cells were able to induce neovascularization in the infarcted myocardium in an equivalent manner. Few human cells were detected in the infarcted myocardium of the rats 28 days after transplantation suggesting that the effects observed might be related primarily to paracrine activity. Although both cell populations ameliorated the infarcted heart and are suitable for regeneration of the vascular system, expanded CD133+ cells are more beneficial and promising candidates for vascular regeneration.Endothelial Progenitor CellsMyocardial InfarctionTherapeuticsGuided Tissue RegenerationCélulas Progenitoras EndotelialesInfarto del MiocardioTerapéuticaRegeneración Tisular DirigidaCélulas Progenitoras EndoteliaisInfarto do MiocárdioTerapêuticaRegeneração Tecidual Guiadainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/40109/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL5412478ok.pdf5412478ok.pdfapplication/pdf2305810https://www.arca.fiocruz.br/bitstream/icict/40109/2/5412478ok.pdf2150bf8afab087bc945e1e84cba39390MD52TEXT5412478ok.pdf.txt5412478ok.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction |
title |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction |
spellingShingle |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction Correa, Alejandro Endothelial Progenitor Cells Myocardial Infarction Therapeutics Guided Tissue Regeneration Células Progenitoras Endoteliales Infarto del Miocardio Terapéutica Regeneración Tisular Dirigida Células Progenitoras Endoteliais Infarto do Miocárdio Terapêutica Regeneração Tecidual Guiada |
title_short |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction |
title_full |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction |
title_fullStr |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction |
title_full_unstemmed |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction |
title_sort |
Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction |
author |
Correa, Alejandro |
author_facet |
Correa, Alejandro Ottoboni, Gabriel Salles Senegaglia, Alexandra Cristina Capriglione, Luiz Guilherme Achcar Miyague, Nelson Itiro Leite, Lidiane Maria Boldrini Jamur, Valderez Ravaglio Rebelatto, Carmen Lúcia Kuniyoshi Olandoski, Márcia Brofman, Paulo Roberto Slud |
author_role |
author |
author2 |
Ottoboni, Gabriel Salles Senegaglia, Alexandra Cristina Capriglione, Luiz Guilherme Achcar Miyague, Nelson Itiro Leite, Lidiane Maria Boldrini Jamur, Valderez Ravaglio Rebelatto, Carmen Lúcia Kuniyoshi Olandoski, Márcia Brofman, Paulo Roberto Slud |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Correa, Alejandro Ottoboni, Gabriel Salles Senegaglia, Alexandra Cristina Capriglione, Luiz Guilherme Achcar Miyague, Nelson Itiro Leite, Lidiane Maria Boldrini Jamur, Valderez Ravaglio Rebelatto, Carmen Lúcia Kuniyoshi Olandoski, Márcia Brofman, Paulo Roberto Slud |
dc.subject.en.pt_BR.fl_str_mv |
Endothelial Progenitor Cells Myocardial Infarction Therapeutics Guided Tissue Regeneration |
topic |
Endothelial Progenitor Cells Myocardial Infarction Therapeutics Guided Tissue Regeneration Células Progenitoras Endoteliales Infarto del Miocardio Terapéutica Regeneración Tisular Dirigida Células Progenitoras Endoteliais Infarto do Miocárdio Terapêutica Regeneração Tecidual Guiada |
dc.subject.es.pt_BR.fl_str_mv |
Células Progenitoras Endoteliales Infarto del Miocardio Terapéutica Regeneración Tisular Dirigida |
dc.subject.decs.pt_BR.fl_str_mv |
Células Progenitoras Endoteliais Infarto do Miocárdio Terapêutica Regeneração Tecidual Guiada |
description |
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-02-20T18:31:35Z |
dc.date.available.fl_str_mv |
2020-02-20T18:31:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CORREA, Alejandro et al. Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction. Stem Cells International, p. 1–11, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/40109 |
dc.identifier.issn.pt_BR.fl_str_mv |
1687-9678 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2018/5412478 |
dc.identifier.eissn.none.fl_str_mv |
1687-9678 |
identifier_str_mv |
CORREA, Alejandro et al. Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction. Stem Cells International, p. 1–11, 2018. 1687-9678 10.1155/2018/5412478 |
url |
https://www.arca.fiocruz.br/handle/icict/40109 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Hindawi |
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Hindawi |
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