High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1

Detalhes bibliográficos
Autor(a) principal: Primo, Janeusa Rita Leite
Data de Publicação: 2009
Outros Autores: Siqueira, Isadora Cristina de, Nascimento, M. C. F, Oliveira, M. F, Vale, Lourdes Farre, Carvalho Filho, Edgar Marcelino, Bittencourt, Achilea Candida Lisboa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5941
Resumo: Departamento de Medicina Interna. Salvador, BA, Brasil
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spelling Primo, Janeusa Rita LeiteSiqueira, Isadora Cristina deNascimento, M. C. FOliveira, M. FVale, Lourdes FarreCarvalho Filho, Edgar MarcelinoBittencourt, Achilea Candida Lisboa2012-12-07T21:31:59Z2012-12-07T21:31:59Z2009PRIMO, J. et al. High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. Brazilian Journal of Medical Biological Research, v. 42, n. 8, p. 761-764, aug. 2009.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/5941engHigh HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartamento de Medicina Interna. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, BrasilDepartamento de Medicina Interna. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, BrasilSalvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. HTLV-1 carriers may develop a variety of diseases such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). IDH is a chronic and severe form of childhood exudative and infective dermatitis involving mainly the scalp, neck and ears. It has recently been observed that 30% of patients with IDH develop juvenile HAM/TSP. The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers. In the current study, the proviral load of 28 children and adolescents with IDH not associated with HAM/TSP was determined and the results were compared to those obtained in 28 HTLV-1 adult carriers and 28 adult patients with HAM/TSP. The proviral load in IDH patients was similar to that of patients with HAM/TSP and much higher than that found in HTLV-1 carriers. The high levels of proviral load in IDH patients were not associated with age, duration of illness, duration of breast-feeding, or activity status of the skin disease. Since proviral load is associated with neurological disability, these data support the view that IDH patients are at high risk of developing HAM/TSP.Infective dermatitis associated with HTLV-1HTLV-1-associated myelopathy/tropical spastic paraparesisHTLV-1 proviral loadsDermatite/virologiaVirus Linfotrópico de Células T HumanasTipo 1/isolamento & purificaçãoParaparesia Espástica Tropical/virologiaDermatopatias Virais/virologiaMarcadores Biológicos/análisePortador SadioDNA Viral/análiseProgressão da DoençaVirus Linfotrópico de Células T HumanasTipo 1/genéticaProvirus/genéticaFatores de RiscoCarga ViralAdolescenteAdultoCriançaPré-EscolarFemininoMasculinoHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPrimo, J et al High HTLV-1 proviral....pdfPrimo, J et al High HTLV-1 proviral....pdfapplication/pdf205691https://www.arca.fiocruz.br/bitstream/icict/5941/1/Primo%2c%20J%20et%20al%20High%20HTLV-1%20proviral....pdf0ac849f5c55d22ee52eb1e0537361d3dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5941/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTPrimo, J et al High HTLV-1 proviral....pdf.txtPrimo, J et al High HTLV-1 proviral....pdf.txtExtracted texttext/plain14950https://www.arca.fiocruz.br/bitstream/icict/5941/5/Primo%2c%20J%20et%20al%20High%20HTLV-1%20proviral....pdf.txtf496187097ea0048ef925914a60db2aeMD55THUMBNAILPrimo, J et al High HTLV-1 proviral....pdf.jpgPrimo, J et al High HTLV-1 proviral....pdf.jpgGenerated Thumbnailimage/jpeg2323https://www.arca.fiocruz.br/bitstream/icict/5941/4/Primo%2c%20J%20et%20al%20High%20HTLV-1%20proviral....pdf.jpg174853318c7c386dafa71e122676325aMD54icict/59412023-03-15 14:32:58.35oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
title High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
spellingShingle High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
Primo, Janeusa Rita Leite
Infective dermatitis associated with HTLV-1
HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1 proviral loads
Dermatite/virologia
Virus Linfotrópico de Células T Humanas
Tipo 1/isolamento & purificação
Paraparesia Espástica Tropical/virologia
Dermatopatias Virais/virologia
Marcadores Biológicos/análise
Portador Sadio
DNA Viral/análise
Progressão da Doença
Virus Linfotrópico de Células T Humanas
Tipo 1/genética
Provirus/genética
Fatores de Risco
Carga Viral
Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Masculino
Humanos
title_short High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
title_full High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
title_fullStr High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
title_full_unstemmed High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
title_sort High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
author Primo, Janeusa Rita Leite
author_facet Primo, Janeusa Rita Leite
Siqueira, Isadora Cristina de
Nascimento, M. C. F
Oliveira, M. F
Vale, Lourdes Farre
Carvalho Filho, Edgar Marcelino
Bittencourt, Achilea Candida Lisboa
author_role author
author2 Siqueira, Isadora Cristina de
Nascimento, M. C. F
Oliveira, M. F
Vale, Lourdes Farre
Carvalho Filho, Edgar Marcelino
Bittencourt, Achilea Candida Lisboa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Primo, Janeusa Rita Leite
Siqueira, Isadora Cristina de
Nascimento, M. C. F
Oliveira, M. F
Vale, Lourdes Farre
Carvalho Filho, Edgar Marcelino
Bittencourt, Achilea Candida Lisboa
dc.subject.en.pt_BR.fl_str_mv Infective dermatitis associated with HTLV-1
HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1 proviral loads
topic Infective dermatitis associated with HTLV-1
HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1 proviral loads
Dermatite/virologia
Virus Linfotrópico de Células T Humanas
Tipo 1/isolamento & purificação
Paraparesia Espástica Tropical/virologia
Dermatopatias Virais/virologia
Marcadores Biológicos/análise
Portador Sadio
DNA Viral/análise
Progressão da Doença
Virus Linfotrópico de Células T Humanas
Tipo 1/genética
Provirus/genética
Fatores de Risco
Carga Viral
Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Masculino
Humanos
dc.subject.decs.pt_BR.fl_str_mv Dermatite/virologia
Virus Linfotrópico de Células T Humanas
Tipo 1/isolamento & purificação
Paraparesia Espástica Tropical/virologia
Dermatopatias Virais/virologia
Marcadores Biológicos/análise
Portador Sadio
DNA Viral/análise
Progressão da Doença
Virus Linfotrópico de Células T Humanas
Tipo 1/genética
Provirus/genética
Fatores de Risco
Carga Viral
Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Masculino
Humanos
description Departamento de Medicina Interna. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-12-07T21:31:59Z
dc.date.available.fl_str_mv 2012-12-07T21:31:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PRIMO, J. et al. High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. Brazilian Journal of Medical Biological Research, v. 42, n. 8, p. 761-764, aug. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5941
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv PRIMO, J. et al. High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. Brazilian Journal of Medical Biological Research, v. 42, n. 8, p. 761-764, aug. 2009.
0100-879X
url https://www.arca.fiocruz.br/handle/icict/5941
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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