Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice

Detalhes bibliográficos
Autor(a) principal: Maciel, Marcia Cristina Gonçalves
Data de Publicação: 2014
Outros Autores: Fialho, Eder Magalhães Silva, Guerra, Rosane Nassar Meireles, Borges, Valeria de Matos, Kwasniewski, Fabio Henrique, Nascimento, Flávia Raquel Fernandes do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7874
Resumo: Universidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, Brasil
id CRUZ_e679499568ae868e725a4106c7d2588b
oai_identifier_str oai:www.arca.fiocruz.br:icict/7874
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Maciel, Marcia Cristina GonçalvesFialho, Eder Magalhães SilvaGuerra, Rosane Nassar MeirelesBorges, Valeria de MatosKwasniewski, Fabio HenriqueNascimento, Flávia Raquel Fernandes do2014-07-07T17:28:35Z2014-07-07T17:28:35Z2014MACIEL, M. C. et al. Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice. Toxicon, p. 1-8, 2014.0041-0101https://www.arca.fiocruz.br/handle/icict/787410.1016/j.toxicon.2014.06.018engElsevier LtdTityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, BrasilUniversidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, BrasilUniversidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Estadual de Londrina. Laborat orio de Imunofarmacologia. Departamento de Ciências Patol ogicas. Centro de Ciências Biol ogicas. Londrina, PR, BrasilUniversidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, BrasilTityus serrulatus venom (Tsv) modifies the behavior of immune cells and induces the production of inflammatory and anti-inflammatory cytokines; such action may interfere with physiological or pathological states. Because sepsis is characterized as an inflammatory disorder, the aim of present study was to investigate the effect of a non-lethal dose of Tsv in mice submitted to a polymicrobial infection by cecal ligation and puncture (CLP) model. The parameters evaluated were survival index, cellularity on lymphoid organs, peritoneal cavity and brochoalveolar space, production of IL-10, IL-12, IL-6, TNF-a, IFN-g and MCP-1, pulmonary inflammation and oxidative burst. The results demonstrated that in sharp contrast to CLP group in which sepsis was lethal in a 24 h period all mice pretreated with Tsv survived even 60 h after CLP. Lung inflammation, another hallmark of CLP group, was also dramatically down regulated in Tsv/CLP group. Despite pretreatment with Tsv did not reduce the inflammatory serum cytokines when compared to CLP group; there was an increase in IL-10. In conclusion, subcutaneous Tsv administration 6 h before CLP was able to control the harmful effects of sepsis (lethality and lung inflammation). We suggest that both systemic IL-10 and oxidative burst are involved in this effectTityus serrulatusVenomCLPSepsisInflammationCytokinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMaciel MC Tityus serrulatus....pdfMaciel MC Tityus serrulatus....pdfapplication/pdf958216https://www.arca.fiocruz.br/bitstream/icict/7874/1/Maciel%20MC%20Tityus%20serrulatus....pdfcac508f5fee8daa8738adf84e70f79ffMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7874/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMaciel MC Tityus serrulatus....pdf.txtMaciel MC Tityus serrulatus....pdf.txtExtracted texttext/plain44426https://www.arca.fiocruz.br/bitstream/icict/7874/3/Maciel%20MC%20Tityus%20serrulatus....pdf.txtbb750735b123ea3b94fe7c9fe8690ea6MD53icict/78742023-03-15 14:33:15.909oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
title Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
spellingShingle Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
Maciel, Marcia Cristina Gonçalves
Tityus serrulatus
Venom
CLP
Sepsis
Inflammation
Cytokines
title_short Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
title_full Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
title_fullStr Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
title_full_unstemmed Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
title_sort Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
author Maciel, Marcia Cristina Gonçalves
author_facet Maciel, Marcia Cristina Gonçalves
Fialho, Eder Magalhães Silva
Guerra, Rosane Nassar Meireles
Borges, Valeria de Matos
Kwasniewski, Fabio Henrique
Nascimento, Flávia Raquel Fernandes do
author_role author
author2 Fialho, Eder Magalhães Silva
Guerra, Rosane Nassar Meireles
Borges, Valeria de Matos
Kwasniewski, Fabio Henrique
Nascimento, Flávia Raquel Fernandes do
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Maciel, Marcia Cristina Gonçalves
Fialho, Eder Magalhães Silva
Guerra, Rosane Nassar Meireles
Borges, Valeria de Matos
Kwasniewski, Fabio Henrique
Nascimento, Flávia Raquel Fernandes do
dc.subject.en.pt_BR.fl_str_mv Tityus serrulatus
Venom
CLP
Sepsis
Inflammation
Cytokines
topic Tityus serrulatus
Venom
CLP
Sepsis
Inflammation
Cytokines
description Universidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, Brasil
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-07-07T17:28:35Z
dc.date.available.fl_str_mv 2014-07-07T17:28:35Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACIEL, M. C. et al. Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice. Toxicon, p. 1-8, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7874
dc.identifier.issn.none.fl_str_mv 0041-0101
dc.identifier.doi.none.fl_str_mv 10.1016/j.toxicon.2014.06.018
identifier_str_mv MACIEL, M. C. et al. Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice. Toxicon, p. 1-8, 2014.
0041-0101
10.1016/j.toxicon.2014.06.018
url https://www.arca.fiocruz.br/handle/icict/7874
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Ltd
publisher.none.fl_str_mv Elsevier Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7874/1/Maciel%20MC%20Tityus%20serrulatus....pdf
https://www.arca.fiocruz.br/bitstream/icict/7874/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/7874/3/Maciel%20MC%20Tityus%20serrulatus....pdf.txt
bitstream.checksum.fl_str_mv cac508f5fee8daa8738adf84e70f79ff
7d48279ffeed55da8dfe2f8e81f3b81f
bb750735b123ea3b94fe7c9fe8690ea6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324977554948096

Registros relacionados