Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35602 |
Resumo: | 2020-03-16 |
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Damasceno, Lisandra SerraTeixeira, Marcus de MeloBarker, Bridget MarieAlmeida, Marcos AbreuMuniz, Mauro de MedeirosPizzini, Cláudia VeraMesquita, Jacó Ricarte LimaRodríguez-Arellanes, GabrielaRamírez, José AntonioVite-Garín, TaniaLeitão, Terezinha do Menino Jesus SilvaTaylor, Maria LuciaAlmeida-Paes, RodrigoZancopé-Oliveira, Rosely Maria2019-09-16T13:18:07Z2019-09-16T13:18:07Z2019DAMASCENO, Lisandra Serra et al. Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil. Scientific Reports, v. 9, p. 1-12, 2019.0028-0836https://www.arca.fiocruz.br/handle/icict/3560210.1038/s41598-019-48111-61476-4687engNature ResearchNovel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-03-16Secretaria de Saúde do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil.Universidade de Brasília. Universidade de Brasília. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Northern Arizona University. Pathogen and Microbiome Institute. Flagstaf, AZ, USA.Universidade de Brasília. Universidade de Brasília. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Northern Arizona University. Pathogen and Microbiome Institute. Flagstaf, AZ, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Northern Arizona University. Pathogen and Microbiome Institute. Flagstaf, AZ, USA.Northern Arizona University. Pathogen and Microbiome Institute. Flagstaf, AZ, USA.Secretaria de Saúde do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil.Universidad Nacional Autónoma de México. Facultad de Medicina. Departamento de Microbiología y Parasitología. Laboratorio de Inmunología de Hongos. Ciudad de México, Mexico.Universidad Nacional Autónoma de México. Facultad de Medicina. Departamento de Microbiología y Parasitología. Laboratorio de Inmunología de Hongos. Ciudad de México, Mexico.Universidad Nacional Autónoma de México. Facultad de Medicina. Departamento de Microbiología y Parasitología. Laboratorio de Inmunología de Hongos. Ciudad de México, Mexico.Secretaria de Saúde do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil / Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Saúde Comunitária. Fortaleza, CE, Brasil.Universidad Nacional Autónoma de México. Facultad de Medicina. Departamento de Microbiología y Parasitología. Laboratorio de Inmunología de Hongos. Ciudad de México, Mexico.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Histoplasmosis is a worldwide-distributed deep mycosis that affects healthy and immunocompromised hosts. Severe and disseminated disease is especially common in HIV-infected patients. At least 11 phylogenetic species are recognized and the majority of diversity is found in Latin America. The northeastern region of Brazil has one of the highest HIV/AIDS prevalence in Latin America and Ceará State has one of the highest death rates due to histoplasmosis in the world, where the mortality rate varies between 33-42%. The phylogenetic distribution and population genetic structure of 51 clinical isolates from Northeast Brazil was studied. For that morphological characteristics, exoantigens profile, and fungal mating types were evaluated. The genotypes were deduced by a MSLT in order to define local population structure of this fungal pathogen. In addition, the relationships of H. capsulatum genotypes with clinically relevant phenotypes and clinical aspects were investigated. The results suggest two cryptic species, herein named population Northeast BR1 and population Northeast BR2. These populations are recombining, exhibit a high level of haplotype diversity, and contain different ratios of mating types MAT1-1 and MAT1-2. However, differences in phenotypes or clinical aspects were not observed within these new cryptic species. A HIV patient can be co-infected by two or more genotypes from Northeast BR1 and/or Northeast BR2, which may have significant impact on disease progression due to the impaired immune response. We hypothesize that co-infections could be the result of multiple exposure events and may indicate higher risk of disseminated histoplasmosis, especially in HIV infected patients.Histoplasma capsulatumHistoplasmosisHIV patientsNortheastern BrazilBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/35602/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Damasceno_Lisandra_etal_INI_2019.pdfve_Damasceno_Lisandra_etal_INI_2019.pdfapplication/pdf2731274https://www.arca.fiocruz.br/bitstream/icict/35602/2/ve_Damasceno_Lisandra_etal_INI_2019.pdf14abfbd9194fce21c52755d5b6ebe985MD52TEXTve_Damasceno_Lisandra_etal_INI_2019.pdf.txtve_Damasceno_Lisandra_etal_INI_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil |
| title |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil |
| spellingShingle |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil Damasceno, Lisandra Serra Histoplasma capsulatum Histoplasmosis HIV patients Northeastern Brazil Brazil |
| title_short |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil |
| title_full |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil |
| title_fullStr |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil |
| title_full_unstemmed |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil |
| title_sort |
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil |
| author |
Damasceno, Lisandra Serra |
| author_facet |
Damasceno, Lisandra Serra Teixeira, Marcus de Melo Barker, Bridget Marie Almeida, Marcos Abreu Muniz, Mauro de Medeiros Pizzini, Cláudia Vera Mesquita, Jacó Ricarte Lima Rodríguez-Arellanes, Gabriela Ramírez, José Antonio Vite-Garín, Tania Leitão, Terezinha do Menino Jesus Silva Taylor, Maria Lucia Almeida-Paes, Rodrigo Zancopé-Oliveira, Rosely Maria |
| author_role |
author |
| author2 |
Teixeira, Marcus de Melo Barker, Bridget Marie Almeida, Marcos Abreu Muniz, Mauro de Medeiros Pizzini, Cláudia Vera Mesquita, Jacó Ricarte Lima Rodríguez-Arellanes, Gabriela Ramírez, José Antonio Vite-Garín, Tania Leitão, Terezinha do Menino Jesus Silva Taylor, Maria Lucia Almeida-Paes, Rodrigo Zancopé-Oliveira, Rosely Maria |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Damasceno, Lisandra Serra Teixeira, Marcus de Melo Barker, Bridget Marie Almeida, Marcos Abreu Muniz, Mauro de Medeiros Pizzini, Cláudia Vera Mesquita, Jacó Ricarte Lima Rodríguez-Arellanes, Gabriela Ramírez, José Antonio Vite-Garín, Tania Leitão, Terezinha do Menino Jesus Silva Taylor, Maria Lucia Almeida-Paes, Rodrigo Zancopé-Oliveira, Rosely Maria |
| dc.subject.en.pt_BR.fl_str_mv |
Histoplasma capsulatum Histoplasmosis HIV patients Northeastern Brazil Brazil |
| topic |
Histoplasma capsulatum Histoplasmosis HIV patients Northeastern Brazil Brazil |
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2020-03-16 |
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2019 |
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2019-09-16T13:18:07Z |
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2019-09-16T13:18:07Z |
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2019 |
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info:eu-repo/semantics/article |
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DAMASCENO, Lisandra Serra et al. Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil. Scientific Reports, v. 9, p. 1-12, 2019. |
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https://www.arca.fiocruz.br/handle/icict/35602 |
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0028-0836 |
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10.1038/s41598-019-48111-6 |
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1476-4687 |
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DAMASCENO, Lisandra Serra et al. Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil. Scientific Reports, v. 9, p. 1-12, 2019. 0028-0836 10.1038/s41598-019-48111-6 1476-4687 |
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Nature Research |
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