Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals

Bibliographic Details
Main Author: Bonin, Carla Rezende Barbosa
Publication Date: 2020
Other Authors: Fernandes, Guilherme Côrtes, Martins, Reinaldo de Menezes, Camacho, Luiz Antonio Bastos, Teixeira-Carvalho, Andréa, Mota, Licia Maria Henrique da, Lima, Sheila Maria Barbosa de, Campi-Azevedo, Ana Carolina, Martins-Filho, Olindo Assis, Santos, Rodrigo Weber dos, Lobosco, Marcelo
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/45774
Summary: Instituto Federal do Sudeste de Minas Gerais. Campus Avançado Cataguases. Cataguases, MG, Brasil.
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spelling Bonin, Carla Rezende BarbosaFernandes, Guilherme CôrtesMartins, Reinaldo de MenezesCamacho, Luiz Antonio BastosTeixeira-Carvalho, AndréaMota, Licia Maria Henrique daLima, Sheila Maria Barbosa deCampi-Azevedo, Ana CarolinaMartins-Filho, Olindo AssisSantos, Rodrigo Weber dosLobosco, Marcelo2021-01-21T19:16:21Z2021-01-21T19:16:21Z2020BONIN, Carla Rezende Barbosa et al. Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals. BMC Bioinformatics, v. 21, Suppl 17, p. 1-25, 2020.1471-2105https://www.arca.fiocruz.br/handle/icict/4577410.1186/s12859-020-03845-3engModelagem Computacional Específica para o PacienteSistema ImunitárioVacinasFebre AmarelaComputational ModelingImmune SystemMathematical ModelingOrdinary Differential EquationsVaccineYellow FeverImmune SystemYellow FeverPatient-Specific ModelingVaccinesValidation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Federal do Sudeste de Minas Gerais. Campus Avançado Cataguases. Cataguases, MG, Brasil.Centro Universitário Presidente Antônio Carlos. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade de Brasilia. Brasilia, DF, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Juiz de Fora. Programa de Pós-Graduação em Modelagem Computacional. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Programa de Pós-Graduação em Modelagem Computacional. Juiz de Fora, MG, Brasil.Background: An effective yellow fever (YF) vaccine has been available since 1937. Nevertheless, questions regarding its use remain poorly understood, such as the ideal dose to confer immunity against the disease, the need for a booster dose, the optimal immunisation schedule for immunocompetent, immunosuppressed, and pediatric populations, among other issues. This work aims to demonstrate that computational tools can be used to simulate different scenarios regarding YF vaccination and the immune response of individuals to this vaccine, thus assisting the response of some of these open questions. Results: This work presents the computational results obtained by a mathematical model of the human immune response to vaccination against YF. Five scenarios were simulated: primovaccination in adults and children, booster dose in adult individuals, vaccination of individuals with autoimmune diseases under immunomodulatory therapy, and the immune response to different vaccine doses. Where data were available, the model was able to quantitatively replicate the levels of antibodies obtained experimentally. In addition, for those scenarios where data were not available, it was possible to qualitatively reproduce the immune response behaviours described in the literature. Conclusions: Our simulations show that the minimum dose to confer immunity against YF is half of the reference dose. The results also suggest that immunological immaturity in children limits the induction and persistence of long-lived plasma cells are related to the antibody decay observed experimentally. Finally, the decay observed in the antibody level after ten years suggests that a booster dose is necessary to keep immunity against YF.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45774/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALValidationYellowFeverVaccine.pdfValidationYellowFeverVaccine.pdfapplication/pdf1730767https://www.arca.fiocruz.br/bitstream/icict/45774/2/ValidationYellowFeverVaccine.pdfa86d5f9f10c894db1dd9c479eabd94a0MD52TEXTValidationYellowFeverVaccine.pdf.txtValidationYellowFeverVaccine.pdf.txtExtracted texttext/plain70598https://www.arca.fiocruz.br/bitstream/icict/45774/3/ValidationYellowFeverVaccine.pdf.txt8f370b110fae5fc2ec2a1e69af1be014MD53icict/457742021-02-10 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dc.title.pt_BR.fl_str_mv Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
title Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
spellingShingle Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
Bonin, Carla Rezende Barbosa
Modelagem Computacional Específica para o Paciente
Sistema Imunitário
Vacinas
Febre Amarela
Computational Modeling
Immune System
Mathematical Modeling
Ordinary Differential Equations
Vaccine
Yellow Fever
Immune System
Yellow Fever
Patient-Specific Modeling
Vaccines
title_short Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
title_full Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
title_fullStr Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
title_full_unstemmed Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
title_sort Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
author Bonin, Carla Rezende Barbosa
author_facet Bonin, Carla Rezende Barbosa
Fernandes, Guilherme Côrtes
Martins, Reinaldo de Menezes
Camacho, Luiz Antonio Bastos
Teixeira-Carvalho, Andréa
Mota, Licia Maria Henrique da
Lima, Sheila Maria Barbosa de
Campi-Azevedo, Ana Carolina
Martins-Filho, Olindo Assis
Santos, Rodrigo Weber dos
Lobosco, Marcelo
author_role author
author2 Fernandes, Guilherme Côrtes
Martins, Reinaldo de Menezes
Camacho, Luiz Antonio Bastos
Teixeira-Carvalho, Andréa
Mota, Licia Maria Henrique da
Lima, Sheila Maria Barbosa de
Campi-Azevedo, Ana Carolina
Martins-Filho, Olindo Assis
Santos, Rodrigo Weber dos
Lobosco, Marcelo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bonin, Carla Rezende Barbosa
Fernandes, Guilherme Côrtes
Martins, Reinaldo de Menezes
Camacho, Luiz Antonio Bastos
Teixeira-Carvalho, Andréa
Mota, Licia Maria Henrique da
Lima, Sheila Maria Barbosa de
Campi-Azevedo, Ana Carolina
Martins-Filho, Olindo Assis
Santos, Rodrigo Weber dos
Lobosco, Marcelo
dc.subject.other.pt_BR.fl_str_mv Modelagem Computacional Específica para o Paciente
Sistema Imunitário
Vacinas
Febre Amarela
topic Modelagem Computacional Específica para o Paciente
Sistema Imunitário
Vacinas
Febre Amarela
Computational Modeling
Immune System
Mathematical Modeling
Ordinary Differential Equations
Vaccine
Yellow Fever
Immune System
Yellow Fever
Patient-Specific Modeling
Vaccines
dc.subject.en.pt_BR.fl_str_mv Computational Modeling
Immune System
Mathematical Modeling
Ordinary Differential Equations
Vaccine
Yellow Fever
dc.subject.decs.pt_BR.fl_str_mv Immune System
Yellow Fever
Patient-Specific Modeling
Vaccines
description Instituto Federal do Sudeste de Minas Gerais. Campus Avançado Cataguases. Cataguases, MG, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-21T19:16:21Z
dc.date.available.fl_str_mv 2021-01-21T19:16:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BONIN, Carla Rezende Barbosa et al. Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals. BMC Bioinformatics, v. 21, Suppl 17, p. 1-25, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45774
dc.identifier.issn.pt_BR.fl_str_mv 1471-2105
dc.identifier.doi.none.fl_str_mv 10.1186/s12859-020-03845-3
identifier_str_mv BONIN, Carla Rezende Barbosa et al. Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals. BMC Bioinformatics, v. 21, Suppl 17, p. 1-25, 2020.
1471-2105
10.1186/s12859-020-03845-3
url https://www.arca.fiocruz.br/handle/icict/45774
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/45774/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/45774/2/ValidationYellowFeverVaccine.pdf
https://www.arca.fiocruz.br/bitstream/icict/45774/3/ValidationYellowFeverVaccine.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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