Procalcitonin is useful in identifying bacteraemia among children with pneumonia.

Detalhes bibliográficos
Autor(a) principal: Carvalho, Cristiana Maria Costa Nascimento
Data de Publicação: 2010
Outros Autores: Cardoso, Maria Regina Alves, Barral, Aldina Maria Prado, Araújo Neto, César Augusto de, Guerin, Sylvie, Saukkoriipi, Annika, Paldanius, Mika, Vainionpaa, Raija, Lebon, Pierre, Leinonen, Maija, Ruuskanen, Olli, Genfrel, Dominique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9285
Resumo: Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Pediatria. Salvador, BA, Brasil
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spelling Carvalho, Cristiana Maria Costa NascimentoCardoso, Maria Regina AlvesBarral, Aldina Maria PradoAraújo Neto, César Augusto deGuerin, SylvieSaukkoriipi, AnnikaPaldanius, MikaVainionpaa, RaijaLebon, PierreLeinonen, MaijaRuuskanen, OlliGenfrel, Dominique2014-12-22T18:47:43Z2014-12-22T18:47:43Z2010NASCIMENTO-CARVALHO, C. M. et al. Procalcitonin is useful in identifying bacteraemia among children with pneumonia. Scandinavian Journal of Infectious Disease, v. 42, n. 9, p. 644-649, 2010.1651-1980https://www.arca.fiocruz.br/handle/icict/928510.3109/00365541003796775engInforma HealthcareProcalcitonin is useful in identifying bacteraemia among children with pneumonia.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Pediatria. Salvador, BA, BrasilSão Paulo University. Faculty of Public Health. Epidemiology Department. São Paulo, SP, BrasilUniversidade Federal da Bahia. Escola de Medicina. Departamento de Diagnóstico de Patologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Diagnóstico de Imagem. Salvador, BA, BrasilParis Descartes University. St Vincent-Cochin Hospital. Paris, FranceNational Institute for Health and Welfare. Oulu, FinlandNational Institute for Health and Welfare. Oulu, FinlandUniversity of Turku. Virology. Turku, FinlandParis Descartes University. St Vincent-Cochin Hospital. Paris, FranceNational Institute for Health and Welfare. Oulu, FinlandUniversity of Turku. Paediatrics Department. Turku, FinlandParis Descartes University. St Vincent-Cochin Hospital. Paris, FranceEmpirical antibiotic use is prescribed in managing children with pneumonia worldwide. We assessed the usefulness of procalcitonin (PCT) and interferon-alpha (IFN- α ) in differentiating viral from bacterial pneumonia. Among 159 hospitalized children, pneumonia was diagnosed based on clinical complaints plus pulmonary infi ltrate. Aetiology was investigated for 9 viruses and 4 atypical and 3 typical bacteria. PCT and IFN- α were measured in the serum sample collected on admission. Eight patients had bacteraemic infections, 38 had non-bacteraemic typical infections, and 19 patients had atypical bacterial infections. Viral and unknown aetiology was established in 57 (36%) and 34 (21%) cases, respectively. Three patients with bacterial infection without collected blood culture were excluded. IFN- α (IU/ml) was detectable in 20 (13%) cases. The difference among median PCT values of the bacteraemic (4.22; 1.56 – 7.56), non-bacteraemic typical bacterial (1.47; 0.24 – 4.07), atypical bacterial (0.18; 0.06 – 1.03) and only viral (0.65; 0.11 – 2.22) subgroups was signifi cant ( p 0.02). PCT was 2 ng/ml in 52 (33%) cases. The presence of IFN- α was associated with PCT 2 ng/ml (90% vs. 64%, p 0.02). The negative predictive value (95% confi dence interval) of PCT 2 ng/ml was 95% (89 – 100%), 89% (78 – 100%), 93% (85 – 100%) for differentiation of bacteraemic from viral, atypical bacterial and nonbacteraemic typical bacterial infection, respectively, and 58% (49 – 68%) for differentiation between bacterial and viral infection. PCT may be useful in identifying bacteraemia among children hospitalized with community-acquired pneumonia. IFN- α was uncommonly detected.Bacteriemia/diagnósticoCalcitonina/sanguePneumonia Bacteriana/diagnósticoPneumonia Viral/diagnósticoPrecursores de Proteínas/sangueBacteriemia/sanguePré-EscolarInfecções Comunitárias Adquiridas/sangueInfecções Comunitárias Adquiridas/diagnósticoDiagnóstico DiferencialFemininoHumanosLactenteRecém-NascidoInterferon-alfa/sangueMasculinoPneumonia Bacteriana/sanguePneumonia Bacteriana/microbiologiaValor Preditivo dos TestesEstudos ProspectivosCurva ROCReprodutibilidade dos TestesEstatísticas não Paramétricasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9285/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALNascimento-Carvalho CM Procalcitonin is useful....pdfNascimento-Carvalho CM Procalcitonin is useful....pdfapplication/pdf120414https://www.arca.fiocruz.br/bitstream/icict/9285/2/Nascimento-Carvalho%20CM%20Procalcitonin%20is%20useful....pdf5a88036f201a432801728f2e814e780dMD52TEXTNascimento-Carvalho CM Procalcitonin is useful....pdf.txtNascimento-Carvalho CM Procalcitonin is useful....pdf.txtExtracted texttext/plain25728https://www.arca.fiocruz.br/bitstream/icict/9285/3/Nascimento-Carvalho%20CM%20Procalcitonin%20is%20useful....pdf.txt79a7cbd236286cf6670c8917ac115360MD53icict/92852023-03-15 14:33:03.614oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
title Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
spellingShingle Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
Carvalho, Cristiana Maria Costa Nascimento
Bacteriemia/diagnóstico
Calcitonina/sangue
Pneumonia Bacteriana/diagnóstico
Pneumonia Viral/diagnóstico
Precursores de Proteínas/sangue
Bacteriemia/sangue
Pré-Escolar
Infecções Comunitárias Adquiridas/sangue
Infecções Comunitárias Adquiridas/diagnóstico
Diagnóstico Diferencial
Feminino
Humanos
Lactente
Recém-Nascido
Interferon-alfa/sangue
Masculino
Pneumonia Bacteriana/sangue
Pneumonia Bacteriana/microbiologia
Valor Preditivo dos Testes
Estudos Prospectivos
Curva ROC
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
title_short Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
title_full Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
title_fullStr Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
title_full_unstemmed Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
title_sort Procalcitonin is useful in identifying bacteraemia among children with pneumonia.
author Carvalho, Cristiana Maria Costa Nascimento
author_facet Carvalho, Cristiana Maria Costa Nascimento
Cardoso, Maria Regina Alves
Barral, Aldina Maria Prado
Araújo Neto, César Augusto de
Guerin, Sylvie
Saukkoriipi, Annika
Paldanius, Mika
Vainionpaa, Raija
Lebon, Pierre
Leinonen, Maija
Ruuskanen, Olli
Genfrel, Dominique
author_role author
author2 Cardoso, Maria Regina Alves
Barral, Aldina Maria Prado
Araújo Neto, César Augusto de
Guerin, Sylvie
Saukkoriipi, Annika
Paldanius, Mika
Vainionpaa, Raija
Lebon, Pierre
Leinonen, Maija
Ruuskanen, Olli
Genfrel, Dominique
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Cristiana Maria Costa Nascimento
Cardoso, Maria Regina Alves
Barral, Aldina Maria Prado
Araújo Neto, César Augusto de
Guerin, Sylvie
Saukkoriipi, Annika
Paldanius, Mika
Vainionpaa, Raija
Lebon, Pierre
Leinonen, Maija
Ruuskanen, Olli
Genfrel, Dominique
dc.subject.decs.pt_BR.fl_str_mv Bacteriemia/diagnóstico
Calcitonina/sangue
Pneumonia Bacteriana/diagnóstico
Pneumonia Viral/diagnóstico
Precursores de Proteínas/sangue
Bacteriemia/sangue
Pré-Escolar
Infecções Comunitárias Adquiridas/sangue
Infecções Comunitárias Adquiridas/diagnóstico
Diagnóstico Diferencial
Feminino
Humanos
Lactente
Recém-Nascido
Interferon-alfa/sangue
Masculino
Pneumonia Bacteriana/sangue
Pneumonia Bacteriana/microbiologia
Valor Preditivo dos Testes
Estudos Prospectivos
Curva ROC
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
topic Bacteriemia/diagnóstico
Calcitonina/sangue
Pneumonia Bacteriana/diagnóstico
Pneumonia Viral/diagnóstico
Precursores de Proteínas/sangue
Bacteriemia/sangue
Pré-Escolar
Infecções Comunitárias Adquiridas/sangue
Infecções Comunitárias Adquiridas/diagnóstico
Diagnóstico Diferencial
Feminino
Humanos
Lactente
Recém-Nascido
Interferon-alfa/sangue
Masculino
Pneumonia Bacteriana/sangue
Pneumonia Bacteriana/microbiologia
Valor Preditivo dos Testes
Estudos Prospectivos
Curva ROC
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
description Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Pediatria. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-12-22T18:47:43Z
dc.date.available.fl_str_mv 2014-12-22T18:47:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NASCIMENTO-CARVALHO, C. M. et al. Procalcitonin is useful in identifying bacteraemia among children with pneumonia. Scandinavian Journal of Infectious Disease, v. 42, n. 9, p. 644-649, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9285
dc.identifier.issn.none.fl_str_mv 1651-1980
dc.identifier.doi.none.fl_str_mv 10.3109/00365541003796775
identifier_str_mv NASCIMENTO-CARVALHO, C. M. et al. Procalcitonin is useful in identifying bacteraemia among children with pneumonia. Scandinavian Journal of Infectious Disease, v. 42, n. 9, p. 644-649, 2010.
1651-1980
10.3109/00365541003796775
url https://www.arca.fiocruz.br/handle/icict/9285
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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