Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Natalia Fintelman
Data de Publicação: 2021
Outros Autores: Silva, Aline P.D. da, Santos, Monique Cristina dos, Saraiva, Felipe, Ferreira, Marcelo, Gesto, João, Rodrigues, Danielle A.S., Vale, André, Azevedo, Isaclaudia de, Soares, Vinícius, Jiang, Hui, Tan, Hongdong, Tschoeke, Diogo A., Sacramento, Carolina, Bozza, Fernando A., Morel, Carlos Medicis, Bozza, Patrícia Torres, Souza, Thiago Moreno L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article
https://www.arca.fiocruz.br/handle/icict/46571
Resumo: We thank Carmen Beatriz Wagner and Giacoia Gripp for assessments related to the Biosafety Level 3 facility and Marco Alberto Medeiros for assessments related to the sequencing platform. We thank Gonzalo Bello, Dumith Chequer Bou-Habib, Willian Provance, and Fabiano Thompson for insightful discussions. We greatly appreciated the MGI, a partner in the implementation of next-generation sequencing through collaborations with Oswaldo Cruz Foundation, especially for challenging samples of COVID-19. Author contributions: F.A.B. and P.T.B. conducted clinical surveillance. N.F.R. and F.A.B. enrolled patients in the study. N.F.R., C.Q.S., D.R., I.G.A., V.C.S. performed immunologic assessments. N.F.R., A.P.D.S., M.C.S., F.B.S., M.A.F., J.G., H.J., and H.T. performed sequencing. A.P.D.S., M.C.S., and D.A.T were responsible for bioinformatics. F.A.B., P.T.B., C.M.M., T.M.L.S. handled study coordination. N.F.R., P.T.B., A.MV., and T.M.L.S. prepared and revised the manuscript. All authors revised and approved the manuscript.
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spelling Rodrigues, Natalia FintelmanSilva, Aline P.D. daSantos, Monique Cristina dosSaraiva, FelipeFerreira, MarceloGesto, JoãoRodrigues, Danielle A.S.Vale, AndréAzevedo, Isaclaudia deSoares, ViníciusJiang, HuiTan, HongdongTschoeke, Diogo A.Sacramento, CarolinaBozza, Fernando A.Morel, Carlos MedicisBozza, Patrícia TorresSouza, Thiago Moreno L.2021-04-08T15:45:47Z2021-04-08T15:45:47Z2021https://wwwnc.cdc.gov/eid/article/27/5/20-4912_articleRODRIGUES, Natalia Fintelman et al. Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil. Emerging Infectious Diseases, v. 27, n. 5, p. 1-7, maio 2021.1080-6059https://www.arca.fiocruz.br/handle/icict/4657110.3201/eid2705.204912We thank Carmen Beatriz Wagner and Giacoia Gripp for assessments related to the Biosafety Level 3 facility and Marco Alberto Medeiros for assessments related to the sequencing platform. We thank Gonzalo Bello, Dumith Chequer Bou-Habib, Willian Provance, and Fabiano Thompson for insightful discussions. We greatly appreciated the MGI, a partner in the implementation of next-generation sequencing through collaborations with Oswaldo Cruz Foundation, especially for challenging samples of COVID-19. Author contributions: F.A.B. and P.T.B. conducted clinical surveillance. N.F.R. and F.A.B. enrolled patients in the study. N.F.R., C.Q.S., D.R., I.G.A., V.C.S. performed immunologic assessments. N.F.R., A.P.D.S., M.C.S., F.B.S., M.A.F., J.G., H.J., and H.T. performed sequencing. A.P.D.S., M.C.S., and D.A.T were responsible for bioinformatics. F.A.B., P.T.B., C.M.M., T.M.L.S. handled study coordination. N.F.R., P.T.B., A.MV., and T.M.L.S. prepared and revised the manuscript. All authors revised and approved the manuscript.Mostra que uma primeira exposição à Covid-19 em casos brandos ou assintomáticos pode não produzir resposta imunológica e que a pessoa pode se reinfectar, inclusive, com a mesma variante. A segunda infecção pode provocar sintomas mais fortes do que a primeira. Os dados mostram que para a parcela da população que tem a doença na forma branda (em que não é necessária a hospitalização) isso não significa que fique imune ou que uma reinfecção evolua de forma benigna. O estudo indica ainda que a reinfecção pode ser mais frequente do que se supõe.The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.MGI Tech Co., Ltd. Shenzhen, China.MGI Tech Co., Ltd. Shenzhen, China.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.engCDCCoronavirus InfectionsBrazilCOVID-19SARS-CoV-2ReinfecçãoBrasilCOVID-19SARS-CoV-2ReinfectedBrazilInfecções por CoronavirusBrasilGenetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83128https://www.arca.fiocruz.br/bitstream/icict/46571/1/license.txt0a01a23320286399b52cf17eb1aafb12MD51ORIGINALGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfapplication/pdf540659https://www.arca.fiocruz.br/bitstream/icict/46571/2/Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf7787c50e338b570d6480a277df163c8fMD52Table - Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfTable - Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfapplication/pdf422208https://www.arca.fiocruz.br/bitstream/icict/46571/3/Table%20-%20Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf664597d3af0d58cdc0cfdd1f86e55d23MD53Appendix.pdfAppendix.pdfapplication/pdf1217474https://www.arca.fiocruz.br/bitstream/icict/46571/4/Appendix.pdf1ed48b1fe0732c10daaaf42ce77ae0d7MD54TEXTGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdf.txtGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, 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dc.title.pt_BR.fl_str_mv Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
title Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
spellingShingle Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
Rodrigues, Natalia Fintelman
Coronavirus Infections
Brazil
COVID-19
SARS-CoV-2
Reinfecção
Brasil
COVID-19
SARS-CoV-2
Reinfected
Brazil
Infecções por Coronavirus
Brasil
title_short Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
title_full Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
title_fullStr Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
title_full_unstemmed Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
title_sort Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
author Rodrigues, Natalia Fintelman
author_facet Rodrigues, Natalia Fintelman
Silva, Aline P.D. da
Santos, Monique Cristina dos
Saraiva, Felipe
Ferreira, Marcelo
Gesto, João
Rodrigues, Danielle A.S.
Vale, André
Azevedo, Isaclaudia de
Soares, Vinícius
Jiang, Hui
Tan, Hongdong
Tschoeke, Diogo A.
Sacramento, Carolina
Bozza, Fernando A.
Morel, Carlos Medicis
Bozza, Patrícia Torres
Souza, Thiago Moreno L.
author_role author
author2 Silva, Aline P.D. da
Santos, Monique Cristina dos
Saraiva, Felipe
Ferreira, Marcelo
Gesto, João
Rodrigues, Danielle A.S.
Vale, André
Azevedo, Isaclaudia de
Soares, Vinícius
Jiang, Hui
Tan, Hongdong
Tschoeke, Diogo A.
Sacramento, Carolina
Bozza, Fernando A.
Morel, Carlos Medicis
Bozza, Patrícia Torres
Souza, Thiago Moreno L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Natalia Fintelman
Silva, Aline P.D. da
Santos, Monique Cristina dos
Saraiva, Felipe
Ferreira, Marcelo
Gesto, João
Rodrigues, Danielle A.S.
Vale, André
Azevedo, Isaclaudia de
Soares, Vinícius
Jiang, Hui
Tan, Hongdong
Tschoeke, Diogo A.
Sacramento, Carolina
Bozza, Fernando A.
Morel, Carlos Medicis
Bozza, Patrícia Torres
Souza, Thiago Moreno L.
dc.subject.mesh.pt_BR.fl_str_mv Coronavirus Infections
Brazil
topic Coronavirus Infections
Brazil
COVID-19
SARS-CoV-2
Reinfecção
Brasil
COVID-19
SARS-CoV-2
Reinfected
Brazil
Infecções por Coronavirus
Brasil
dc.subject.other.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
Reinfecção
Brasil
dc.subject.en.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
Reinfected
Brazil
dc.subject.decs.pt_BR.fl_str_mv Infecções por Coronavirus
Brasil
description We thank Carmen Beatriz Wagner and Giacoia Gripp for assessments related to the Biosafety Level 3 facility and Marco Alberto Medeiros for assessments related to the sequencing platform. We thank Gonzalo Bello, Dumith Chequer Bou-Habib, Willian Provance, and Fabiano Thompson for insightful discussions. We greatly appreciated the MGI, a partner in the implementation of next-generation sequencing through collaborations with Oswaldo Cruz Foundation, especially for challenging samples of COVID-19. Author contributions: F.A.B. and P.T.B. conducted clinical surveillance. N.F.R. and F.A.B. enrolled patients in the study. N.F.R., C.Q.S., D.R., I.G.A., V.C.S. performed immunologic assessments. N.F.R., A.P.D.S., M.C.S., F.B.S., M.A.F., J.G., H.J., and H.T. performed sequencing. A.P.D.S., M.C.S., and D.A.T were responsible for bioinformatics. F.A.B., P.T.B., C.M.M., T.M.L.S. handled study coordination. N.F.R., P.T.B., A.MV., and T.M.L.S. prepared and revised the manuscript. All authors revised and approved the manuscript.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-08T15:45:47Z
dc.date.available.fl_str_mv 2021-04-08T15:45:47Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.pt_BR.fl_str_mv https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article
dc.identifier.citation.fl_str_mv RODRIGUES, Natalia Fintelman et al. Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil. Emerging Infectious Diseases, v. 27, n. 5, p. 1-7, maio 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46571
dc.identifier.issn.pt_BR.fl_str_mv 1080-6059
dc.identifier.doi.none.fl_str_mv 10.3201/eid2705.204912
url https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article
https://www.arca.fiocruz.br/handle/icict/46571
identifier_str_mv RODRIGUES, Natalia Fintelman et al. Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil. Emerging Infectious Diseases, v. 27, n. 5, p. 1-7, maio 2021.
1080-6059
10.3201/eid2705.204912
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CDC
publisher.none.fl_str_mv CDC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/46571/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/46571/2/Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf
https://www.arca.fiocruz.br/bitstream/icict/46571/3/Table%20-%20Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf
https://www.arca.fiocruz.br/bitstream/icict/46571/4/Appendix.pdf
https://www.arca.fiocruz.br/bitstream/icict/46571/5/Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/46571/6/Table%20-%20Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/46571/7/Appendix.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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