Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article https://www.arca.fiocruz.br/handle/icict/46571 |
Resumo: | We thank Carmen Beatriz Wagner and Giacoia Gripp for assessments related to the Biosafety Level 3 facility and Marco Alberto Medeiros for assessments related to the sequencing platform. We thank Gonzalo Bello, Dumith Chequer Bou-Habib, Willian Provance, and Fabiano Thompson for insightful discussions. We greatly appreciated the MGI, a partner in the implementation of next-generation sequencing through collaborations with Oswaldo Cruz Foundation, especially for challenging samples of COVID-19. Author contributions: F.A.B. and P.T.B. conducted clinical surveillance. N.F.R. and F.A.B. enrolled patients in the study. N.F.R., C.Q.S., D.R., I.G.A., V.C.S. performed immunologic assessments. N.F.R., A.P.D.S., M.C.S., F.B.S., M.A.F., J.G., H.J., and H.T. performed sequencing. A.P.D.S., M.C.S., and D.A.T were responsible for bioinformatics. F.A.B., P.T.B., C.M.M., T.M.L.S. handled study coordination. N.F.R., P.T.B., A.MV., and T.M.L.S. prepared and revised the manuscript. All authors revised and approved the manuscript. |
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Rodrigues, Natalia FintelmanSilva, Aline P.D. daSantos, Monique Cristina dosSaraiva, FelipeFerreira, MarceloGesto, JoãoRodrigues, Danielle A.S.Vale, AndréAzevedo, Isaclaudia deSoares, ViníciusJiang, HuiTan, HongdongTschoeke, Diogo A.Sacramento, CarolinaBozza, Fernando A.Morel, Carlos MedicisBozza, Patrícia TorresSouza, Thiago Moreno L.2021-04-08T15:45:47Z2021-04-08T15:45:47Z2021https://wwwnc.cdc.gov/eid/article/27/5/20-4912_articleRODRIGUES, Natalia Fintelman et al. Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil. Emerging Infectious Diseases, v. 27, n. 5, p. 1-7, maio 2021.1080-6059https://www.arca.fiocruz.br/handle/icict/4657110.3201/eid2705.204912We thank Carmen Beatriz Wagner and Giacoia Gripp for assessments related to the Biosafety Level 3 facility and Marco Alberto Medeiros for assessments related to the sequencing platform. We thank Gonzalo Bello, Dumith Chequer Bou-Habib, Willian Provance, and Fabiano Thompson for insightful discussions. We greatly appreciated the MGI, a partner in the implementation of next-generation sequencing through collaborations with Oswaldo Cruz Foundation, especially for challenging samples of COVID-19. Author contributions: F.A.B. and P.T.B. conducted clinical surveillance. N.F.R. and F.A.B. enrolled patients in the study. N.F.R., C.Q.S., D.R., I.G.A., V.C.S. performed immunologic assessments. N.F.R., A.P.D.S., M.C.S., F.B.S., M.A.F., J.G., H.J., and H.T. performed sequencing. A.P.D.S., M.C.S., and D.A.T were responsible for bioinformatics. F.A.B., P.T.B., C.M.M., T.M.L.S. handled study coordination. N.F.R., P.T.B., A.MV., and T.M.L.S. prepared and revised the manuscript. All authors revised and approved the manuscript.Mostra que uma primeira exposição à Covid-19 em casos brandos ou assintomáticos pode não produzir resposta imunológica e que a pessoa pode se reinfectar, inclusive, com a mesma variante. A segunda infecção pode provocar sintomas mais fortes do que a primeira. Os dados mostram que para a parcela da população que tem a doença na forma branda (em que não é necessária a hospitalização) isso não significa que fique imune ou que uma reinfecção evolua de forma benigna. O estudo indica ainda que a reinfecção pode ser mais frequente do que se supõe.The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.MGI Tech Co., Ltd. Shenzhen, China.MGI Tech Co., Ltd. Shenzhen, China.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.engCDCCoronavirus InfectionsBrazilCOVID-19SARS-CoV-2ReinfecçãoBrasilCOVID-19SARS-CoV-2ReinfectedBrazilInfecções por CoronavirusBrasilGenetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83128https://www.arca.fiocruz.br/bitstream/icict/46571/1/license.txt0a01a23320286399b52cf17eb1aafb12MD51ORIGINALGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfapplication/pdf540659https://www.arca.fiocruz.br/bitstream/icict/46571/2/Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf7787c50e338b570d6480a277df163c8fMD52Table - Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfTable - Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdfapplication/pdf422208https://www.arca.fiocruz.br/bitstream/icict/46571/3/Table%20-%20Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf664597d3af0d58cdc0cfdd1f86e55d23MD53Appendix.pdfAppendix.pdfapplication/pdf1217474https://www.arca.fiocruz.br/bitstream/icict/46571/4/Appendix.pdf1ed48b1fe0732c10daaaf42ce77ae0d7MD54TEXTGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.pdf.txtGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, 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dc.title.pt_BR.fl_str_mv |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
title |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
spellingShingle |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil Rodrigues, Natalia Fintelman Coronavirus Infections Brazil COVID-19 SARS-CoV-2 Reinfecção Brasil COVID-19 SARS-CoV-2 Reinfected Brazil Infecções por Coronavirus Brasil |
title_short |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
title_full |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
title_fullStr |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
title_full_unstemmed |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
title_sort |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
author |
Rodrigues, Natalia Fintelman |
author_facet |
Rodrigues, Natalia Fintelman Silva, Aline P.D. da Santos, Monique Cristina dos Saraiva, Felipe Ferreira, Marcelo Gesto, João Rodrigues, Danielle A.S. Vale, André Azevedo, Isaclaudia de Soares, Vinícius Jiang, Hui Tan, Hongdong Tschoeke, Diogo A. Sacramento, Carolina Bozza, Fernando A. Morel, Carlos Medicis Bozza, Patrícia Torres Souza, Thiago Moreno L. |
author_role |
author |
author2 |
Silva, Aline P.D. da Santos, Monique Cristina dos Saraiva, Felipe Ferreira, Marcelo Gesto, João Rodrigues, Danielle A.S. Vale, André Azevedo, Isaclaudia de Soares, Vinícius Jiang, Hui Tan, Hongdong Tschoeke, Diogo A. Sacramento, Carolina Bozza, Fernando A. Morel, Carlos Medicis Bozza, Patrícia Torres Souza, Thiago Moreno L. |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Natalia Fintelman Silva, Aline P.D. da Santos, Monique Cristina dos Saraiva, Felipe Ferreira, Marcelo Gesto, João Rodrigues, Danielle A.S. Vale, André Azevedo, Isaclaudia de Soares, Vinícius Jiang, Hui Tan, Hongdong Tschoeke, Diogo A. Sacramento, Carolina Bozza, Fernando A. Morel, Carlos Medicis Bozza, Patrícia Torres Souza, Thiago Moreno L. |
dc.subject.mesh.pt_BR.fl_str_mv |
Coronavirus Infections Brazil |
topic |
Coronavirus Infections Brazil COVID-19 SARS-CoV-2 Reinfecção Brasil COVID-19 SARS-CoV-2 Reinfected Brazil Infecções por Coronavirus Brasil |
dc.subject.other.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Reinfecção Brasil |
dc.subject.en.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Reinfected Brazil |
dc.subject.decs.pt_BR.fl_str_mv |
Infecções por Coronavirus Brasil |
description |
We thank Carmen Beatriz Wagner and Giacoia Gripp for assessments related to the Biosafety Level 3 facility and Marco Alberto Medeiros for assessments related to the sequencing platform. We thank Gonzalo Bello, Dumith Chequer Bou-Habib, Willian Provance, and Fabiano Thompson for insightful discussions. We greatly appreciated the MGI, a partner in the implementation of next-generation sequencing through collaborations with Oswaldo Cruz Foundation, especially for challenging samples of COVID-19. Author contributions: F.A.B. and P.T.B. conducted clinical surveillance. N.F.R. and F.A.B. enrolled patients in the study. N.F.R., C.Q.S., D.R., I.G.A., V.C.S. performed immunologic assessments. N.F.R., A.P.D.S., M.C.S., F.B.S., M.A.F., J.G., H.J., and H.T. performed sequencing. A.P.D.S., M.C.S., and D.A.T were responsible for bioinformatics. F.A.B., P.T.B., C.M.M., T.M.L.S. handled study coordination. N.F.R., P.T.B., A.MV., and T.M.L.S. prepared and revised the manuscript. All authors revised and approved the manuscript. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-04-08T15:45:47Z |
dc.date.available.fl_str_mv |
2021-04-08T15:45:47Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.pt_BR.fl_str_mv |
https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article |
dc.identifier.citation.fl_str_mv |
RODRIGUES, Natalia Fintelman et al. Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil. Emerging Infectious Diseases, v. 27, n. 5, p. 1-7, maio 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/46571 |
dc.identifier.issn.pt_BR.fl_str_mv |
1080-6059 |
dc.identifier.doi.none.fl_str_mv |
10.3201/eid2705.204912 |
url |
https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article https://www.arca.fiocruz.br/handle/icict/46571 |
identifier_str_mv |
RODRIGUES, Natalia Fintelman et al. Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil. Emerging Infectious Diseases, v. 27, n. 5, p. 1-7, maio 2021. 1080-6059 10.3201/eid2705.204912 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
CDC |
publisher.none.fl_str_mv |
CDC |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/46571/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/46571/2/Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf https://www.arca.fiocruz.br/bitstream/icict/46571/3/Table%20-%20Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf https://www.arca.fiocruz.br/bitstream/icict/46571/4/Appendix.pdf https://www.arca.fiocruz.br/bitstream/icict/46571/5/Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/46571/6/Table%20-%20Genetic%20Evidence%20and%20Host%20Immune%20Response%20in%20Persons%20Reinfected%20with%20SARS-CoV-2%2c%20Brazil.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/46571/7/Appendix.pdf.txt |
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repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
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1798324837478825984 |