Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40896 |
Resumo: | Acesso aberto em 20/04/2020 - https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.200635968 |
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Magalhães, Elizabeth S.Mourao-Sa, Diego S.Abreu, Adriana Vieira deFigueredo, Rodrigo T.Pires, Ana L.Farias Filho, Francisco A.Fonseca, Bruna P. F.Viola, João P. B.Metz, ChristineMartins, Marco A.Faria Neto, Hugo Caire C.Bozza, Patrícia T.Bozza, Marcelo T.2020-04-20T18:29:13Z2020-04-20T18:29:13Z2007MAGALHÃES, Elizabeth S. et al. Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Clinical Immunology, v. 37, p. 1097-1106, 2007.1521-6616https://www.arca.fiocruz.br/handle/icict/4089610.1002/eji.2006359681521-7035Acesso aberto em 20/04/2020 - https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.200635968Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil.Institute for Medical Research at North Shore LIJ. Laboratory of Medicinal Biochemistry. Manhasset, NY, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Macrophage migration inhibitory factor (MIF) is increased in asthmatic patients and plays a critical role in the pathogenesis of asthma. We show here that mice lacking MIF failed to develop airway hyper-responsiveness (AHR), tissue eosinophilia, and mucus metaplasia. Analysis of the bronchoalveolar fluids revealed a substantial reduction of IL-13, eotaxin and cysteinyl-leukotrienes. The lack of these cardinal features of asthma in MIF–/– mice occurs regardless of high concentrations of IL-4 in the lung and OVAspecific IgE in the serum. Antigen-specific lymphocyte proliferation and IL-13 production were similarly increased in the draining lymph nodes of OVA-immunized and challenged MIF–/– mice compared to WT, but were reduced in the spleen of MIF–/–, thus indicating differential roles of MIF in these compartments. Stimulation of naive CD4+ cells with anti-CD3 antibody demonstrated that MIF–/– cells produced increased amounts of IFN-c and IL-4 compared to WT CD4+ cells. Finally, treatment of sensitized BALB/c mice with neutralizing anti-MIF antibody abrogated the development of ARH and airway inflammation without affecting the production of Th2 cytokines or IgE. The present study demonstrates that MIF is required for allergic inflammation, adding important elements to our knowledge of asthma pathogenesis and suggesting that neutralization of MIF might be of therapeutic value in asthma.engElsevierHiper-responsividade das vias aéreasAsmaInflamaçãoEosinófilosAirway hyper-responsivenessAsthmaEosinophilsInflammationTh1-Th2Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation |
| title |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation |
| spellingShingle |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation Magalhães, Elizabeth S. Hiper-responsividade das vias aéreas Asma Inflamação Eosinófilos Airway hyper-responsiveness Asthma Eosinophils Inflammation Th1-Th2 |
| title_short |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation |
| title_full |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation |
| title_fullStr |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation |
| title_full_unstemmed |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation |
| title_sort |
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation |
| author |
Magalhães, Elizabeth S. |
| author_facet |
Magalhães, Elizabeth S. Mourao-Sa, Diego S. Abreu, Adriana Vieira de Figueredo, Rodrigo T. Pires, Ana L. Farias Filho, Francisco A. Fonseca, Bruna P. F. Viola, João P. B. Metz, Christine Martins, Marco A. Faria Neto, Hugo Caire C. Bozza, Patrícia T. Bozza, Marcelo T. |
| author_role |
author |
| author2 |
Mourao-Sa, Diego S. Abreu, Adriana Vieira de Figueredo, Rodrigo T. Pires, Ana L. Farias Filho, Francisco A. Fonseca, Bruna P. F. Viola, João P. B. Metz, Christine Martins, Marco A. Faria Neto, Hugo Caire C. Bozza, Patrícia T. Bozza, Marcelo T. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Magalhães, Elizabeth S. Mourao-Sa, Diego S. Abreu, Adriana Vieira de Figueredo, Rodrigo T. Pires, Ana L. Farias Filho, Francisco A. Fonseca, Bruna P. F. Viola, João P. B. Metz, Christine Martins, Marco A. Faria Neto, Hugo Caire C. Bozza, Patrícia T. Bozza, Marcelo T. |
| dc.subject.other.pt_BR.fl_str_mv |
Hiper-responsividade das vias aéreas Asma Inflamação Eosinófilos |
| topic |
Hiper-responsividade das vias aéreas Asma Inflamação Eosinófilos Airway hyper-responsiveness Asthma Eosinophils Inflammation Th1-Th2 |
| dc.subject.en.pt_BR.fl_str_mv |
Airway hyper-responsiveness Asthma Eosinophils Inflammation Th1-Th2 |
| description |
Acesso aberto em 20/04/2020 - https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.200635968 |
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2007 |
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2007 |
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2020-04-20T18:29:13Z |
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2020-04-20T18:29:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MAGALHÃES, Elizabeth S. et al. Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Clinical Immunology, v. 37, p. 1097-1106, 2007. |
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https://www.arca.fiocruz.br/handle/icict/40896 |
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1521-6616 |
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10.1002/eji.200635968 |
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1521-7035 |
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MAGALHÃES, Elizabeth S. et al. Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Clinical Immunology, v. 37, p. 1097-1106, 2007. 1521-6616 10.1002/eji.200635968 1521-7035 |
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