CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23285 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Citometria de Fluxo. Rio de Janeiro, RJ, Brasil. |
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Ferraz, RaquelCunha, Clarissa F.Pimentel, Maria Inês F.Lyra, Marcelo R.Silva, Tatiana Pereira daSchubach, Armando O.Cruz, Alda Maria daBertho, Álvaro Luiz2017-11-21T14:09:14Z2017-11-21T14:09:14Z2017FERRAZ, Raquel et al. CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. Parasites & Vectors, v.10, p. 1-12, May 2017.1756-3305https://www.arca.fiocruz.br/handle/icict/2328510.1186/s13071-017-2152-2engBioMed CentralCitometria de fluxoCitotoxicidadeLinfócitos T de duplo negativoLesãoLeishmaniose cutânea humanaCélulas T Matadoras NaturaisLeishmania braziliensisFlow cytometryCytotoxicityCD107aDouble-negative T lymphocytesNKT cellsLesionHuman cutaneous leishmaniasisLeishmania (Viannia) braziliensisCD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Citometria de Fluxo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Citometria de Fluxo. Rio de Janeiro, RJ, Brasil.Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on an adaptive immune response, and cytotoxic cells seem to have a fundamental role in this process. The aim of this study is to better understand the role of cytotoxicity mediated mechanisms that occur during the immune response in the CL lesion milieu, considering distinct cytotoxic-related CD107a(+) cells, such as CD8(+), CD4(+), CD4(neg) CD8(neg) (double-negative, DN) and CD4(+)CD8(+) (double-positive, DP) T lymphocytes, as well as NK and NKT cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23285/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALraquel_ferraz_etal_IOC_2017.pdfraquel_ferraz_etal_IOC_2017.pdfapplication/pdf5210041https://www.arca.fiocruz.br/bitstream/icict/23285/2/raquel_ferraz_etal_IOC_2017.pdfbe36ec9e1a9c00ad3184e2c76ee6409eMD52TEXTraquel_ferraz_etal_IOC_2017.pdf.txtraquel_ferraz_etal_IOC_2017.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis |
| title |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis |
| spellingShingle |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis Ferraz, Raquel Citometria de fluxo Citotoxicidade Linfócitos T de duplo negativo Lesão Leishmaniose cutânea humana Células T Matadoras Naturais Leishmania braziliensis Flow cytometry Cytotoxicity CD107a Double-negative T lymphocytes NKT cells Lesion Human cutaneous leishmaniasis Leishmania (Viannia) braziliensis |
| title_short |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis |
| title_full |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis |
| title_fullStr |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis |
| title_full_unstemmed |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis |
| title_sort |
CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis |
| author |
Ferraz, Raquel |
| author_facet |
Ferraz, Raquel Cunha, Clarissa F. Pimentel, Maria Inês F. Lyra, Marcelo R. Silva, Tatiana Pereira da Schubach, Armando O. Cruz, Alda Maria da Bertho, Álvaro Luiz |
| author_role |
author |
| author2 |
Cunha, Clarissa F. Pimentel, Maria Inês F. Lyra, Marcelo R. Silva, Tatiana Pereira da Schubach, Armando O. Cruz, Alda Maria da Bertho, Álvaro Luiz |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ferraz, Raquel Cunha, Clarissa F. Pimentel, Maria Inês F. Lyra, Marcelo R. Silva, Tatiana Pereira da Schubach, Armando O. Cruz, Alda Maria da Bertho, Álvaro Luiz |
| dc.subject.other.pt_BR.fl_str_mv |
Citometria de fluxo Citotoxicidade Linfócitos T de duplo negativo Lesão Leishmaniose cutânea humana Células T Matadoras Naturais Leishmania braziliensis |
| topic |
Citometria de fluxo Citotoxicidade Linfócitos T de duplo negativo Lesão Leishmaniose cutânea humana Células T Matadoras Naturais Leishmania braziliensis Flow cytometry Cytotoxicity CD107a Double-negative T lymphocytes NKT cells Lesion Human cutaneous leishmaniasis Leishmania (Viannia) braziliensis |
| dc.subject.en.pt_BR.fl_str_mv |
Flow cytometry Cytotoxicity CD107a Double-negative T lymphocytes NKT cells Lesion Human cutaneous leishmaniasis Leishmania (Viannia) braziliensis |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Citometria de Fluxo. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017-11-21T14:09:14Z |
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2017-11-21T14:09:14Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FERRAZ, Raquel et al. CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. Parasites & Vectors, v.10, p. 1-12, May 2017. |
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https://www.arca.fiocruz.br/handle/icict/23285 |
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1756-3305 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s13071-017-2152-2 |
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FERRAZ, Raquel et al. CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. Parasites & Vectors, v.10, p. 1-12, May 2017. 1756-3305 10.1186/s13071-017-2152-2 |
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BioMed Central |
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BioMed Central |
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