Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!

Detalhes bibliográficos
Autor(a) principal: Pinho, Rosa Teixeira de
Data de Publicação: 2016
Outros Autores: Waghabi, Mariana Caldas, Cardillo, Fabíola, Mengele Junior, José Orivaldo, Antas, Paulo Renato Zuquim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16428
Resumo: CNPq-PQ-2 and FAPERJ-JCNE fellowships (PA), and fully supported by PAPES/CNPq/FIOCRUZ and Fundação Octacílio Gualberto, Faculdade de Medicina de Petropolis (FMP-FASE).
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spelling Pinho, Rosa Teixeira deWaghabi, Mariana CaldasCardillo, FabíolaMengele Junior, José OrivaldoAntas, Paulo Renato Zuquim2016-12-05T19:20:38Z2016-12-05T19:20:38Z2016PINHO, R. T. et al. Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable! Frontiers in Immunology, v. 7, p. 306, 2016.1664-3224https://www.arca.fiocruz.br/handle/icict/1642810.3389/fimmu.2016.00306CNPq-PQ-2 and FAPERJ-JCNE fellowships (PA), and fully supported by PAPES/CNPq/FIOCRUZ and Fundação Octacílio Gualberto, Faculdade de Medicina de Petropolis (FMP-FASE).Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculdade de Medicina de Petropolis (FMP-FASE). Petrópolis, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, BrasilBiomarkers or biosignature profiles have become accessible over time in population-based studies for Chagas disease. Thus, the identification of consistent and reliable indicators of the diagnosis and prognosis of patients with heart failure might facilitate the prioritization of therapeutic management to those with the highest chance of contracting this disease. The purpose of this paper is to review the recent state and the upcoming trends in biomarkers for human Chagas disease. As an emerging concept, we propose a classification of biomarkers based on plasmatic-, phenotype-, antigenic-, genetic-, and management-related candidates. The available data revisited here reveal the lessons learned thus far and the existing challenges that still lie ahead to enable biomarkers to be employed consistently in risk evaluation for this disease. There is a strong need for biomarker validation, particularly for biomarkers that are specific to the clinical forms of Chagas disease. The current failure to achieve the eradication of the transmission of this disease has produced determination to solve this validation issue. Finally, it would be strategic to develop a wide variety of biomarkers and to test them in both preclinical and clinical trials.engFrontiers MediaDoença de chagasBiomarcadoresExperimentação humanaTestes clínicosChagas diseaseBiomarkers for immune responsivenessHuman experimentationClinical formsScrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16428/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPinho RT Scrutinizing the....pdfPinho RT Scrutinizing the....pdfapplication/pdf148854https://www.arca.fiocruz.br/bitstream/icict/16428/2/Pinho%20RT%20Scrutinizing%20the....pdfbf9437d58b1d18248d90438215e348b1MD52TEXTPinho RT Scrutinizing 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dc.title.pt_BR.fl_str_mv Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
title Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
spellingShingle Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
Pinho, Rosa Teixeira de
Doença de chagas
Biomarcadores
Experimentação humana
Testes clínicos
Chagas disease
Biomarkers for immune responsiveness
Human experimentation
Clinical forms
title_short Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
title_full Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
title_fullStr Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
title_full_unstemmed Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
title_sort Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!
author Pinho, Rosa Teixeira de
author_facet Pinho, Rosa Teixeira de
Waghabi, Mariana Caldas
Cardillo, Fabíola
Mengele Junior, José Orivaldo
Antas, Paulo Renato Zuquim
author_role author
author2 Waghabi, Mariana Caldas
Cardillo, Fabíola
Mengele Junior, José Orivaldo
Antas, Paulo Renato Zuquim
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pinho, Rosa Teixeira de
Waghabi, Mariana Caldas
Cardillo, Fabíola
Mengele Junior, José Orivaldo
Antas, Paulo Renato Zuquim
dc.subject.other.pt_BR.fl_str_mv Doença de chagas
Biomarcadores
Experimentação humana
Testes clínicos
topic Doença de chagas
Biomarcadores
Experimentação humana
Testes clínicos
Chagas disease
Biomarkers for immune responsiveness
Human experimentation
Clinical forms
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Biomarkers for immune responsiveness
Human experimentation
Clinical forms
description CNPq-PQ-2 and FAPERJ-JCNE fellowships (PA), and fully supported by PAPES/CNPq/FIOCRUZ and Fundação Octacílio Gualberto, Faculdade de Medicina de Petropolis (FMP-FASE).
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-05T19:20:38Z
dc.date.available.fl_str_mv 2016-12-05T19:20:38Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PINHO, R. T. et al. Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable! Frontiers in Immunology, v. 7, p. 306, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16428
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2016.00306
identifier_str_mv PINHO, R. T. et al. Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable! Frontiers in Immunology, v. 7, p. 306, 2016.
1664-3224
10.3389/fimmu.2016.00306
url https://www.arca.fiocruz.br/handle/icict/16428
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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