WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47661 |
Resumo: | SCAALA (Social change, Asthma and Allergy in Latin America) initiative |
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Carneiro, Valdirene LeãoSilva, Hugo Bernardino Ferreira daQueiroz, Gerson de AlmeidaVeiga, Rafael ValenteOliveira, Pablo Rafael SilveiraCarneiro, Norma Vilany QueirozPires, Anaque de OliveiraSilva, Raimon Rios daSena, FlaviaBelitardo, EmiliaNascimento, ReginaSilva, MilcaMarques, Cintia RodriguesCosta, Ryan dos SantosNeves, Neuza Maria AlcantaraBarreto, Mauricio LimaCooper, Philip J.Figueiredo, Camila Alexandrina2021-06-14T12:30:31Z2021-06-14T12:30:31Z2021CARNEIRO, Valdirene Leão et al. WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides. Frontiers in Immunology, v. 12, p. 1-11, 22 Feb. 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/4766110.3389/fimmu.2021.622051SCAALA (Social change, Asthma and Allergy in Latin America) initiativeWellcome Trust, Grant No. 072405/Z/03/ZBrazilian Ministry of Health (Department of Science and Technology from the Secretaria de Ciência, Tecnologia e Insumos Estratégicos) through Financiadora de Estudos e Projetos, Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB)/CNPq Grant Nos. PRONEX- PNX00001/2014 and PRONEM-PNE0003/2014Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.International University of Ecuador. School of Medicine. Quito, Ecuador / St. George's, University of London. London, United Kingdom.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Genetic and epigenetic factors are considered to be critical for host-parasite interactions. There are limited data on the role of such factors during human infections with Ascaris lumbricoides. Here, we describe the potential role of genetic factors as determinants of the Th2 immune response to A. lumbricoides in Brazilian children. Stool samples were collected from the children to detect A. lumbricoides by microscopy and peripheral blood leukocytes (PBLs) were cultured in whole blood cultures for detection of cytokines (IL-5, IL-10, and IL-13) in vitro. Levels of anti-A. lumbricoides IgE and IgG4 were measured in plasma. DNA was extracted from PBLs and genotyped using Illumina 2.5 Human Omni Beadchip. Candidate genes associated with A. lumbricoides responses were identified and SNVs in these selected genes associated with the Th2 immune response to A. lumbricoides. Haplotype, gene expression, and epigenetic analyses were done to identify potential associations with Th2 immune responses. GWAS on samples from 1,189 children identified WSB1 as a candidate gene, and IL-21R was selected as a biologically relevant linked gene for further analysis. Variants in WSB1 and IL21R were associated with markers of Th2 immune responses: increased A. lumbricoides-specific IgE and IL-5/IL-13 by PBLs from infected compared to uninfected individuals. In infected children, WSB1 but not IL21R gene expression was suppressed and increased methylation was observed in the WSB1 promoter region. This is the first study to show an association between genetic variants in WSB1 and IL21R and Th2 immune responses during A. lumbricoides infections in children. WSB1/IL21R pathways could provide a potential target for the treatment of Th2-mediated diseases.engFrontiers MediaAscaris lumbricoidesImunidadePolimorfismoWSB1IL21RInterações hospedeiro-parasitaExpressão gênicaAscaris lumbricoidesImmunityPolymorphismWSB1IL21RWSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47661/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCarneiro, Valdirene Leao WSB1 and....pdfCarneiro, Valdirene Leao WSB1 and....pdfapplication/pdf1033259https://www.arca.fiocruz.br/bitstream/icict/47661/2/Carneiro%2c%20Valdirene%20Leao%20WSB1%20and....pdf501c7058cbe10f325cffa1d61a9ee4b1MD52TEXTCarneiro, Valdirene Leao WSB1 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| dc.title.en.fl_str_mv |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides |
| title |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides |
| spellingShingle |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides Carneiro, Valdirene Leão Ascaris lumbricoides Imunidade Polimorfismo WSB1 IL21R Interações hospedeiro-parasita Expressão gênica Ascaris lumbricoides Immunity Polymorphism WSB1 IL21R |
| title_short |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides |
| title_full |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides |
| title_fullStr |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides |
| title_full_unstemmed |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides |
| title_sort |
WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides |
| author |
Carneiro, Valdirene Leão |
| author_facet |
Carneiro, Valdirene Leão Silva, Hugo Bernardino Ferreira da Queiroz, Gerson de Almeida Veiga, Rafael Valente Oliveira, Pablo Rafael Silveira Carneiro, Norma Vilany Queiroz Pires, Anaque de Oliveira Silva, Raimon Rios da Sena, Flavia Belitardo, Emilia Nascimento, Regina Silva, Milca Marques, Cintia Rodrigues Costa, Ryan dos Santos Neves, Neuza Maria Alcantara Barreto, Mauricio Lima Cooper, Philip J. Figueiredo, Camila Alexandrina |
| author_role |
author |
| author2 |
Silva, Hugo Bernardino Ferreira da Queiroz, Gerson de Almeida Veiga, Rafael Valente Oliveira, Pablo Rafael Silveira Carneiro, Norma Vilany Queiroz Pires, Anaque de Oliveira Silva, Raimon Rios da Sena, Flavia Belitardo, Emilia Nascimento, Regina Silva, Milca Marques, Cintia Rodrigues Costa, Ryan dos Santos Neves, Neuza Maria Alcantara Barreto, Mauricio Lima Cooper, Philip J. Figueiredo, Camila Alexandrina |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carneiro, Valdirene Leão Silva, Hugo Bernardino Ferreira da Queiroz, Gerson de Almeida Veiga, Rafael Valente Oliveira, Pablo Rafael Silveira Carneiro, Norma Vilany Queiroz Pires, Anaque de Oliveira Silva, Raimon Rios da Sena, Flavia Belitardo, Emilia Nascimento, Regina Silva, Milca Marques, Cintia Rodrigues Costa, Ryan dos Santos Neves, Neuza Maria Alcantara Barreto, Mauricio Lima Cooper, Philip J. Figueiredo, Camila Alexandrina |
| dc.subject.other.pt_BR.fl_str_mv |
Ascaris lumbricoides Imunidade Polimorfismo WSB1 IL21R Interações hospedeiro-parasita Expressão gênica |
| topic |
Ascaris lumbricoides Imunidade Polimorfismo WSB1 IL21R Interações hospedeiro-parasita Expressão gênica Ascaris lumbricoides Immunity Polymorphism WSB1 IL21R |
| dc.subject.en.en.fl_str_mv |
Ascaris lumbricoides Immunity Polymorphism WSB1 IL21R |
| description |
SCAALA (Social change, Asthma and Allergy in Latin America) initiative |
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2021 |
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2021-06-14T12:30:31Z |
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2021-06-14T12:30:31Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CARNEIRO, Valdirene Leão et al. WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides. Frontiers in Immunology, v. 12, p. 1-11, 22 Feb. 2021. |
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https://www.arca.fiocruz.br/handle/icict/47661 |
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1664-3224 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.3389/fimmu.2021.622051 |
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CARNEIRO, Valdirene Leão et al. WSB1 and IL21R genetic variants are involved in Th2 immune responses to Ascaris lumbricoides. Frontiers in Immunology, v. 12, p. 1-11, 22 Feb. 2021. 1664-3224 10.3389/fimmu.2021.622051 |
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