Helminths and Cancers From the Evolutionary Perspective

Detalhes bibliográficos
Autor(a) principal: Scholte, Larissa Lopes Silva
Data de Publicação: 2018
Outros Autores: Xavier, Marcelo Antonio Pascoal, Nahum, Laila Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28831
Resumo: 2020-01-01
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spelling Scholte, Larissa Lopes SilvaXavier, Marcelo Antonio PascoalNahum, Laila Alves2018-09-17T13:57:12Z2018-09-17T13:57:12Z2018SCHOLTE, Larissa Lopes Silva; XAVIER, Marcelo Antonio Pascoal; NAHUM, Laila Alves. Helminths and Cancers From the Evolutionary Perspective. Front Med (Lausanne), v. 5, p. 90, 2018.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/2883110.3389/fmed.2018.00090engFrontiers Media S.Aparasitamicrobiomacancerbiomarcadoresfilogeniaevolução molecularevolução da medicinabioinformaticaparasitemicrobiomecancerbiomarkersphylogenymolecular evolutionevolutionary medicinebioinformaticsHelminths and Cancers From the Evolutionary Perspectiveinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Fundação Oswaldo Cruz Instituto René Rachou. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Vice-Presidência de Pesquisa e Coleções Biológicas. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica. Belo Horizonte,MG, BrazilFundação Oswaldo Cruz Instituto René Rachou. Belo Horizonte, MG, Brazil/Faculdade Promove de Tecnologia. Belo Horizonte, MG, BrazilHelminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes (Schistosoma haematobium, Schistosoma japonicum, and Schistosoma mansoni) and liver flukes (Clonorchis sinensis and Opisthorchis viverrini) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research. Human cancers caused by helminth infection include cholangiocarcinoma, colorectal hepatocellular carcinoma, squamous cell carcinoma, and urinary bladder cancer. Chronic inflammation is proposed as a common pathway for cancer initiation and development. Furthermore, different bacteria present in gastric, colorectal, and urogenital microbiomes might be responsible for enlarging inflammatory and fibrotic responses in cancers. Studies have suggested that different biomarkers are involved in helminth infection and human cancer development; although, the detailed mechanisms remain under debate. Different helminth proteins have been studied by different approaches. However, their evolutionary relationships remain unsolved. Here, we illustrate the strengths of homology identification and function prediction of uncharacterized proteins from genome sequencing projects based on an evolutionary framework. Together, these approaches may help identifying new biomarkers for disease diagnostics and intervention measures. This work has potential applications in the field of phylomedicine (evolutionary medicine) and may contribute to parasite and cancer research.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/28831/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALHelminths and Cancers From the Evolutionary Perspective.pdfHelminths and Cancers From the Evolutionary Perspective.pdfapplication/pdf3730417https://www.arca.fiocruz.br/bitstream/icict/28831/2/Helminths%20and%20Cancers%20From%20the%20Evolutionary%20Perspective.pdf753087de0824cb3cdb08db88a8cd8318MD52TEXTHelminths and Cancers From the Evolutionary Perspective.pdf.txtHelminths and Cancers From the Evolutionary Perspective.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Helminths and Cancers From the Evolutionary Perspective
title Helminths and Cancers From the Evolutionary Perspective
spellingShingle Helminths and Cancers From the Evolutionary Perspective
Scholte, Larissa Lopes Silva
parasita
microbioma
cancer
biomarcadores
filogenia
evolução molecular
evolução da medicina
bioinformatica
parasite
microbiome
cancer
biomarkers
phylogeny
molecular evolution
evolutionary medicine
bioinformatics
title_short Helminths and Cancers From the Evolutionary Perspective
title_full Helminths and Cancers From the Evolutionary Perspective
title_fullStr Helminths and Cancers From the Evolutionary Perspective
title_full_unstemmed Helminths and Cancers From the Evolutionary Perspective
title_sort Helminths and Cancers From the Evolutionary Perspective
author Scholte, Larissa Lopes Silva
author_facet Scholte, Larissa Lopes Silva
Xavier, Marcelo Antonio Pascoal
Nahum, Laila Alves
author_role author
author2 Xavier, Marcelo Antonio Pascoal
Nahum, Laila Alves
author2_role author
author
dc.contributor.author.fl_str_mv Scholte, Larissa Lopes Silva
Xavier, Marcelo Antonio Pascoal
Nahum, Laila Alves
dc.subject.other.pt_BR.fl_str_mv parasita
microbioma
cancer
biomarcadores
filogenia
evolução molecular
evolução da medicina
bioinformatica
topic parasita
microbioma
cancer
biomarcadores
filogenia
evolução molecular
evolução da medicina
bioinformatica
parasite
microbiome
cancer
biomarkers
phylogeny
molecular evolution
evolutionary medicine
bioinformatics
dc.subject.en.pt_BR.fl_str_mv parasite
microbiome
cancer
biomarkers
phylogeny
molecular evolution
evolutionary medicine
bioinformatics
description 2020-01-01
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-17T13:57:12Z
dc.date.available.fl_str_mv 2018-09-17T13:57:12Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHOLTE, Larissa Lopes Silva; XAVIER, Marcelo Antonio Pascoal; NAHUM, Laila Alves. Helminths and Cancers From the Evolutionary Perspective. Front Med (Lausanne), v. 5, p. 90, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28831
dc.identifier.issn.pt_BR.fl_str_mv 2296-858X
dc.identifier.doi.none.fl_str_mv 10.3389/fmed.2018.00090
identifier_str_mv SCHOLTE, Larissa Lopes Silva; XAVIER, Marcelo Antonio Pascoal; NAHUM, Laila Alves. Helminths and Cancers From the Evolutionary Perspective. Front Med (Lausanne), v. 5, p. 90, 2018.
2296-858X
10.3389/fmed.2018.00090
url https://www.arca.fiocruz.br/handle/icict/28831
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A
publisher.none.fl_str_mv Frontiers Media S.A
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/28831/1/license.txt
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